FB2025_01 , released February 20, 2025
Gene Group: RAS GTPASES
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General Information
Name
RAS GTPASES
Species
D. melanogaster
Symbol
RAS
FlyBase ID
FBgg0000324
Date last reviewed
2022-11-01
Number of members
15
Description
Description
The Ras family are members of the Ras superfamily of small GTPases. Ras proteins act in signal transduction cascades, generally the activated GTPase recruits and activates downstream effectors. Members this family are typically membrane-associated via isoprenylation of a CaaX motif in the C-terminus. (Adapted from PMID:15731001).
Notes on Group

RGK family members, sometimes classified as a subclass of the Ras family, are listed in a separate gene group, RGK GTPASES.

κB-Ras differs from other Ras family members: it is constitutively active, binding but not hydrolyzing GTP, and lacks a C-terminal CaaX motif (FBrf0125465). It is therefore excluded from this group.

Source Material
The RAS GTPASES Gene Group has been compiled using the following publication(s): Rojas et al., 2012, Diez et al., 2011, and Colicelli, 2004 .
Key Gene Ontology (GO) terms
Molecular Function
GTPase activity
Biological Process
small GTPase-mediated signal transduction
Cellular Component
Related Gene Groups
Parent group(s)
RAS GTPASE SUPERFAMILY
Other related group(s)
RAS GTPASE ACTIVATING PROTEINS
RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS
Members (15)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG5160
(Diez et al., 2011, Colicelli, 2004)
CG8500
(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)
CG8519
(Diez et al., 2011, Colicelli, 2004)
CG8641
(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)
CG13375
EG:BACR37P7.8
(Diez et al., 2011, Colicelli, 2004)
CG14669
(Rojas et al., 2012)
CG30158
(Diez et al., 2011)
CG42541
(Diez et al., 2011)
Rala
Ras-like protein A
Ral, dRal, Ras-related protein, l(1)G0373, l(1)G0501
(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)
Rap1
Rap1 GTPase
R, Roughened, Dras3, Rap, ras3
(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)
Rap2l
Ras-associated protein 2-like
Rap21
(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)
Ras64B
Ras oncogene at 64B
Ras, Ras2, Dras2, ras-2, Dmras64B
(Diez et al., 2011, Colicelli, 2004)
Ras85D
Ras oncogene at 85D
Ras, Ras1, Dras1, RasV12, dRas
(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)
Rheb
Ras homolog enriched in brain
dRheb, Ras homologue enriched in brain
(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)
Ric
Ras-related protein interacting with calmodulin
(Rojas et al., 2012, Diez et al., 2011, Colicelli, 2004)
External Data
Synonyms and Secondary IDs
Synonym(s)
RAS
RAS GTPASES
Secondary FlyBase ID(s)
References (4)