Open Close
General Information
Name
RAS GTPASES
Species
D. melanogaster
Symbol
RAS
FlyBase ID
FBgg0000324
Date last reviewed
2015-08-06
Number of members
16
Description
Description

The Ras family are members of the Ras superfamily of small GTPases. Ras proteins act in signal transduction cascades, generally the activated GTPase recruits and activates downstream effectors. Members this family are typically membrane-associated via isoprenylation of a CaaX motif in the C-terminus. (Adapted from PMID:15731001).

Notes on Group

κB-Ras differs from other Ras family members. It is constitutively active - it binds but does not hydrolyze GTP and lacks a C-terminal CaaX motif (FBrf0125465).

RGK family members, sometimes classified as a subclass of the Ras family, are listed in a separate gene group, RGK GTPASES.

Source Material
The RAS GTPASES Gene Group has been compiled by FlyBase curators using the following publication(s): Rojas et al., 2012, Diez et al., 2011, and Colicelli, 2004 .
Key Gene Ontology (GO) terms
Molecular Function
Cellular Component
Related Gene Groups
Parent group(s)
Members (16)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Ras-like protein A
Ral, dRal, Ras-related protein, l(1)G0373, l(1)G0501
Rap1 GTPase
R, Roughened, Dras3, Rap, l(3)62Bf
Ras-associated protein 2-like
Rap21
Ras oncogene at 64B
Ras, Ras2, Dras2, ras-2, Dmras64B
Ras oncogene at 85D
Ras, Ras1, Dras1, RasV12, D-Ras
Ras homolog enriched in brain
dRheb, Ras homologue enriched in brain
Ras-related protein interacting with calmodulin
External Data
Synonyms and Secondary IDs
Synonym(s)
RAS
RAS GTPASES
Secondary FlyBase ID(s)
References (4)