FB2025_01 , released February 20, 2025
Gene Group: RHO GTPASE ACTIVATING PROTEINS
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General Information
Name
RHO GTPASE ACTIVATING PROTEINS
Species
D. melanogaster
Symbol
RHOGAP
FlyBase ID
FBgg0000328
Date last reviewed
2015-08-06
Number of members
22
Description
Description
RhoGAPs are GTPase activating proteins for Rho family GTPases. (Adapted from PMID:15731001 and FBrf0158741).
Notes on Group

RhoGAP15B contains both ArfGAP and RhoGAP domains and is therefore listed in both ADP-RIBOSYLATION FACTOR and RHO GTPASE ACTIVATING PROTEINS gene groups.

Ocrl has both an inositol polyphosphate 5-phosphatase catalytic domain and a RhoGAP domain. FBrf0213972 states that both Ocrl and its human ortholog, OCRL, are catalytically inactive. However, human OCRL has been shown to possess a low level of Rac GAP activity in vitro (PMID:12915445).

RhoGAP1A has both RhoGAP and RhoGEF domains. It is likely that these domains target different Rho subfamilies (FBrf0158741).

Source Material
The RHO GTPASE ACTIVATING PROTEINS Gene Group has been compiled using the following publication(s): Neisch et al., 2013, Greenberg and Hatini, 2011, and Bernards, 2003 .
Key Gene Ontology (GO) terms
Molecular Function
GTPase activator activity
Biological Process
Rho protein signal transduction
regulation of GTPase activity
Cellular Component
Related Gene Groups
Parent group(s)
RAS SUPERFAMILY GTPASE ACTIVATING PROTEINS
Other related group(s)
RHO GTPASES
RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
Members (22)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CdGAPr
Cd GTPase activating protein-related
GAP, d-CdGAPr
(Greenberg and Hatini, 2011, Bernards, 2003)
conu
conundrum
(Neisch et al., 2013)
cv-c
crossveinless c
RhoGAP88C, l(3)06951
(Greenberg and Hatini, 2011, Bernards, 2003)
Graf
GTPase regulator associated with FAK
(Greenberg and Hatini, 2011, Bernards, 2003)
Ocrl
Oculocerebrorenal syndrome of Lowe
EG:86E4.5, dOCRL
(Bernards, 2003)
RacGAP84C
Rac GTPase activating protein at 84C
rnRacGAP, RotundRacGAP, P1.7
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP1A
Rho GTPase activating protein at 1A
EG:23E12.2, EG:23E12.5
(Bernards, 2003)
RhoGAP5A
Rho GTPase activating protein at 5A
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP15B
Rho GTPase activating protein at 15B
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP16F
Rho GTPase activating protein at 16F
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP18B
Rho GTPase activating protein at 18B
whir, white rabbit
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP19D
Rho GTPase activating protein at 19D
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP54D
Rho GTPase activating protein at 54D
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP68F
Rho GTPase activating protein at 68F
CG 6811
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP71E
Rho GTPase activating protein at 71E
C-GAP, l(3)j6B9, Cumberland-GAP
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP92B
Rho GTPase activating protein at 92B
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP93B
Rho GTPase activating protein at 93B
vilse, CrGAP
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP100F
Rho GTPase activating protein at 100F
Syd-1, Syd1, DSyd-1
(Greenberg and Hatini, 2011, Bernards, 2003)
RhoGAP102A
Rho GTPase activating protein at 102A
Dm_4:1183, BP1050
(Bernards, 2003)
RhoGAPp190
Rho GTPase activating protein p190
p190RhoGAP, p190, p190 RhoGAP, RhoGAP
(Greenberg and Hatini, 2011, Bernards, 2003)
Rlip
Ral interacting protein
dRalBP, D-RLIP, dRlip
(Bernards, 2003)
tum
tumbleweed
RacGAP50C, acGAP, RacGAP, DRacGAP
(Bernards, 2003)
External Data
Synonyms and Secondary IDs
Synonym(s)
RHOGAP
RHO GTPASE ACTIVATING PROTEINS
Rho-GAP
Secondary FlyBase ID(s)
References (4)