FB2025_01 , released February 20, 2025
Complex: RNA POLYMERASE II
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General Information
Name
RNA POLYMERASE II
Species
D. melanogaster
Symbol
RNAPII
FlyBase ID
FBgg0000351
Date last reviewed
2023-08-08
Number of members
13
Description
Description
RNA Polymerase II (RNAP II) synthesizes mRNAs and a variety of non-coding RNAs, including snRNAs, snoRNAs, microRNAs, piRNAs and lncRNAs. It comprises 12-13 subunits (13 in D. melanogaster), ten of which form a structurally conserved catalytic core with additional subunits located on the periphery. Notably, five RNAP II subunits are shared with the other two nuclear RNAPs. For transcription initiation, RNAPII assembles with the general transcription factors at promoter DNA to form the pre-initiation complex. (Adapted from FBrf0247389, FBrf0228779, FBrf0213652, PMID:25693126, PMID:23463798 and PMID:17318225.)
Notes on Group

While conventional RNAPII is composed of 12 subunits, RNAPII(G) is a metazoan specific form containing a stoichiometric, tightly associated "Gdown1" (aka POLR2M) subunit. (See FBrf0240009.)

Source Material
The RNA POLYMERASE II Gene Group has been compiled using the following publication(s): Marygold et al., 2020, Jishage et al., 2018, and Aoyagi and Wassarman, 2000 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-directed 5'-3' RNA polymerase activity
Biological Process
transcription by RNA polymerase II
Cellular Component
RNA polymerase II, core complex
Enzymatic activity
Enzyme name (EC)
DNA-directed RNA polymerase (2.7.7.6)
Related Gene Groups
Parent group(s)
RNA POLYMERASES
Other related group(s)
GENERAL TRANSCRIPTION FACTORS
RNA POLYMERASE CATALYTIC SUBUNITS
Members (13)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Polr2A
RNA polymerase II subunit A
RNA polymerase II, RpII215, Pol II, RNAPII, PolII
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2B
RNA polymerase II subunit B
RNA polymerase II, RpII140, DmRP140, wimp, PolII
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2C
RNA polymerase II subunit C
Rpb3, RNA polymerase II, RpII33, l(2)34Dg, Pol II
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2D
RNA polymerase II subunit D
Rpb4, DmRPB4
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2E
RNA polymerase II, I and III subunit E
Rpb5, DmRPB5
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2F
RNA polymerase II, I and III subunit F
RNA polymerase II, Pol II, RpII18, PolII, RNA Pol II
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2G
RNA polymerase II subunit G
Rpb7
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2H
RNA polymerase II, I and III subunit H
Rpb8
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2I
RNA polymerase II subunit I
RNA polymerase II, RpII15, PolII, Pol II, Rpb9
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2J
RNA polymerase II subunit J
Rpb11
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2K
RNA polymerase II, I and III subunit K
Rpb12
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2L
RNA polymerase II, I and III subunit L
Rpb10
(Marygold et al., 2020, Aoyagi and Wassarman, 2000)
Polr2M
RNA polymerase II subunit M
Gdown1, Gdn1
(Marygold et al., 2020, Jishage et al., 2018)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RNAPII
RNA POLYMERASE II
DNA-dependent RNA polymerase II
DNA-directed RNA polymerase II
RNA pol II
RPII
Pol II
Secondary FlyBase ID(s)
References (4)