The Mediator (MED) complex serves as a hub for transcriptional signaling events. MED bridges transcriptional activators and repressors. This large multi-protein complex has a central core conserved from yeast to humans. The core is composed of three modules: head, middle, and tail. A separate module, the Cdk8 kinase module, composed of Cdk8, CycC, kto and skd, serves as a regulator. (Adapted from FBrf0226415 and FBrf0191850).
Notes on Group
Some of the Mediator complex subunits have been confirmed experimentally (FBrf0150795) and some by homology with human, yeast or mouse Mediator genes (FBrf0134769 and FBrf0131257).