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General Information
Name
MEDIATOR COMPLEX
Species
D. melanogaster
Symbol
MED
FlyBase ID
FBgg0000359
Date last reviewed
2015-08-25
Number of members
30
Description
Description
The Mediator (MED) complex serves as a hub for transcriptional signaling events. MED bridges transcriptional activators and repressors. This large multi-protein complex has a central core conserved from yeast to humans. The core is composed of three modules: head, middle, and tail. A separate module, the Cdk8 kinase module, composed of Cdk8, CycC, kto and skd, serves as a regulator. (Adapted from FBrf0226415 and FBrf0191850).
Notes on Group
Some of the Mediator complex subunits have been confirmed experimentally (FBrf0150795) and some by homology with human, yeast or mouse Mediator genes (FBrf0134769 and FBrf0131257).
Source Material
The MEDIATOR COMPLEX Gene Group has been compiled by FlyBase curators using the following publication(s): Homem et al., 2014, Marr et al., 2014, Bourbon et al., 2004, Gu et al., 2002, Park et al., 2001, Park et al., 2001, and Boube et al., 2000.
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
Members (30)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Mediator complex subunit 8
Arc32, dARC32
Mediator complex subunit 9
Mediator complex subunit 18
EG:63B12.13, dp28b, p28/CG14802
Mediator complex subunit 19
Mediator complex subunit 20
Trfp, l(2)28DE, Transcription mediator-related, Tmr, lethal(2)28DE
Mediator complex subunit 22
Med24, EG:BACR7A4.6
Mediator complex subunit 25
Arc92, dARC92
Mediator complex subunit 30
Trap25
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
MED
MEDIATOR COMPLEX
Mediator
Secondary FlyBase ID(s)
References (8)