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General Information
Name
SURVIVAL MOTOR NEURON COMPLEX
Species
D. melanogaster
Symbol
SMN-C
FlyBase ID
FBgg0000462
Date last reviewed
2015-10-14
Number of members
7
Description
Description

The survival motor neuron (SMN) complex is minimally composed of SMN and Gemin proteins. The SMN complex mediates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). (Adapted from FBrf0228762).

Notes on Group

It was observed in D.mel that the minimal functional SMN complex is composed of only two subunits, Smn and Gem2 (FBrf0205768).

In vertebrates the SMN complex also includes the Unrip subunit.

Lanfranco et al. (FBrf0237151) suggest that Hez, Sbat and Vlet are orthologous to metazoan Gemin6, Gemin7 and Gemin8, respectively, and are components of the SMN complex. However, the data of Matera et al. (FBrf0241402) argue against this. The composition of the SURVIVAL MOTOR NEURON COMPLEX group reflects conclusions of Matera et al.

Source Material
The SURVIVAL MOTOR NEURON COMPLEX Gene Group has been compiled by FlyBase curators using the following publication(s): Matera et al., 2019, Lanfranco et al., 2017, Borg et al., 2015, Borg and Cauchi, 2013, Cauchi et al., 2010, Shpargel et al., 2009, and Kroiss et al., 2008 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Related Gene Groups
Other related group(s)
Members (7)
For all members:
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
SMN-C
SURVIVAL MOTOR NEURON COMPLEX
SMN-Gemins complex
Secondary FlyBase ID(s)
References (8)