FB2025_01 , released February 20, 2025
Gene Group: ADAM WITH THROMBOSPONDIN MOTIF
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General Information
Name
ADAM WITH THROMBOSPONDIN MOTIF
Species
D. melanogaster
Symbol
ADAMTS
FlyBase ID
FBgg0000476
Date last reviewed
2020-06-08
Number of members
4
Description
Description
A Disintegrin And Metalloprotease Thrombospondin motif (ADAMTS) belongs to the metzincin superfamily of metalloproteases. ADAMTS is related to ADAM proteins, sharing in part their domain organisation. However, ADAMTS includes proteins that contain a variable number of thrombospondin-like repeats instead of disintegrin and cysteine rich domains. ADAMTS proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506).
Notes on Group

Although listed in FBrf0214506 and FBrf0233226 as ADAMTS proteins, loh and Ppn lack the ADAMTS catalytic domain and are included in the 'ADAMTS-LIKE' gene group.

Source Material
The ADAM WITH THROMBOSPONDIN MOTIF Gene Group has been compiled using the following publication(s): Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Nicholson et al., 2005, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
metalloendopeptidase activity
Biological Process
extracellular matrix organization
proteolysis
Cellular Component
Enzymatic activity
Enzyme name (EC)
3.4.24.-
Related Gene Groups
Parent group(s)
METZINCINS
PEPTIDASE FAMILY M12
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
AdamTS-A
ADAM metallopeptidase with thrombospondin type 1 motif A
l(3)89Aa
(FlyBase, 2017-, Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Nicholson et al., 2005, Rawlings and Barrett, 1996-)
AdamTS-B
ADAM metallopeptidase with thrombospondin type 1 motif B
(FlyBase, 2017-, Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Nicholson et al., 2005, Rawlings and Barrett, 1996-)
sona
sol narae
Dimp
(FlyBase, 2017-, Kim et al., 2016, Meyer et al., 2011, Rawlings and Barrett, 1996-)
stl
stall
fs(2)A16
(FlyBase, 2017-, Kim et al., 2016, Ismat et al., 2013, Meyer et al., 2011, Rawlings and Barrett, 1996-)
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Family M12](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=m12)

Synonyms and Secondary IDs
Synonym(s)
ADAMTS
ADAM WITH THROMBOSPONDIN MOTIF
ADAM with thrombospondin type 1 motif
adamalysin-thrombospondin
Secondary FlyBase ID(s)
References (7)