Gene Group: MITOCHONDRIAL COMPLEX II SUBUNITS

General Information

Name

MITOCHONDRIAL COMPLEX II SUBUNITS

Species

D. melanogaster

Symbol

MCII

FlyBase ID

FBgg0000485

Date last reviewed

2021-02-23

Number of members

Description

The succinate dehydrogenase complex is unique in that it functions in both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC), wherein it is referred to as Complex II. It is a heterotetrameric protein complex that is anchored to the inner mitochondrial membrane by two integral membrane proteins, Sdh3 (SDHC) and Sdh4 (SDHD). This Sdh3/Sdh4 dimer binds the peripheral membrane protein Sdh2 (SDHB), which tethers the catalytic Sdh1 (SDHA) subunit to the complex. Sdh1 harbors a covalently bound FAD cofactor that is required for the oxidation of succinate to fumarate in the TCA cycle. The two electrons that result from succinate oxidation are channeled through the three iron-sulfur clusters in Sdh2 to ubiquinone, which interacts with the complex via the Sdh3/Sdh4 membrane anchor, and thereby reduce it to ubiquinol as part of the ETC. (Adapted from PMID:24954416.)

Notes on Group

Three subunits of this complex are encoded by paralogous genes in D. melanogaster: SdhA and SdhAL; SdhB and SdhBL; SdhC and SdhCL. In each case, the first gene has widespread expression, whereas the second copy (the one with 'L' in the symbol) is expressed specifically in the testis.

Source Material

The MITOCHONDRIAL COMPLEX II SUBUNITS Gene Group has been compiled by FlyBase curators using the following publication(s): Vedelek et al., 2018, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, and Tripoli et al., 2005 .

Key Gene Ontology (GO) terms

Molecular Function

succinate dehydrogenase (ubiquinone) activity

electron transfer activity

Biological Process

tricarboxylic acid cycle

mitochondrial electron transport, succinate to ubiquinone

Cellular Component

mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

Related Gene Groups

Parent group(s)

OXIDATIVE PHOSPHORYLATION COMPLEXES AND GROUPS

Other related group(s)

SUCCINATE DEHYDROGENASES

Members (7)

For all members:

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

SdhA

Succinate dehydrogenase, subunit A (flavoprotein)

Scs-fp, sdh, Succinate dehydrogenase A, succinate dehydrogenase, Succinyl coenzyme A synthetase flavoprotein subunit

(Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Tripoli et al., 2005)

SdhAL

Succinate dehydrogenase, subunit A (flavoprotein)-like

(Porcelli and Marygold, 2014.9.16, Caggese et al., 2006, Tripoli et al., 2005)

SdhB

Succinate dehydrogenase, subunit B (iron-sulfur)

Succinate dehydrogenase B, SDH, succinate dehydrogenase

(FlyBase, 2017-, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

SdhBL

Succinate dehydrogenase, subunit B (iron-sulfur)-like

(FlyBase, 2017-, Porcelli and Marygold, 2014.9.16, Tripoli et al., 2005)

SdhC

Succinate dehydrogenase, subunit C

Succinate dehydrogenase C, succinate dehydrogenase

(Vedelek et al., 2018, FlyBase, 2017-, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

SdhCL

Succinate dehydrogenase, subunit C-like

(Vedelek et al., 2018, FlyBase, 2017-)

SdhD

Succinate dehydrogenase, subunit D

(FlyBase, 2017-, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

External Data

Equivalent Group(s)

Human Mitochondrial complex II: succinate dehydrogenase subunits (HGNC)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)