General Information
Name
HEAT SHOCK PROTEINS
Species
D. melanogaster
Symbol
HSP
FlyBase ID
FBgg0000501
Date last reviewed
2016-04-21
Number of members
86
Description
Description
Heat Shock Proteins (HSP) are molecular chaperones found in all organisms. HSPs assist in protein folding and prevent accumulation of damaged, misfolded proteins. They are subdivided in distinct families based on their molecular weight and sequence homology. (Adapted from FBrf0228040 and FBrf0231212).
Notes on Group
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Members (86)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Hsc70Cb
Hsc70, l(3)07621, l(3)70Cb, l(3)70Ca, l(3)00082
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
black pearl
l(3)01618
Cysteine string protein
Dcsp, l(3)03988, ab49
DnaJ-like-1
Hsp40, dHDJ1, DNAJ1, droj1
DnaJ-like-60
DnaJ60
Heat shock protein cognate 20
l(3)72Do
lethal (2) tumorous imaginal discs
l(2)tud, DnaJ, tid
Receptor mediated endocytosis 8
l(2)45Ba
Tetratricopeptide repeat protein 2
dTPR2
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Heat shock protein 60A
Hsp60, l(1)BP5, 12, Hsp64
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Chaperonin containing TCP1 subunit 1
T-cp1, Tcp1-like, T-cpl, Tcp1
Chaperonin containing TCP1 subunit 2
Chaperonin containing TCP1 subunit 3
Cctgamma, Cctγ, Cctg, Y, TCPG_DROME
Chaperonin containing TCP1 subunit 4
Chaperonin containing TCP1 subunit 5
l(2)06444
Chaperonin containing TCP1 subunit 6
Tcp-1zeta, Tcp-1ζ, l(1)G0057, l(1)G0027, l(1)G0022
Chaperonin containing TCP1 subunit 7
Tcp-1eta, Tcp-1η
Chaperonin containing TCP1 subunit 8
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Heat shock protein cognate 1
Hsc70, Hsc1
Heat shock protein cognate 2
Hsc70, hsc2
Heat shock 70-kDa protein cognate 3
BiP, Hsc3, Hsc70, Grp78, l(1)G0102
Heat shock protein cognate 4
Hsc4, Hsc70, BAP74, l(3)L3929
Heat shock protein cognate 5
Hsc5, Hsc70, l(2)k04907
Hsc70Cb
Hsc70, l(3)07621, l(3)70Cb, l(3)70Ca, l(3)00082
Heat shock protein 68
68
Heat-shock-protein-70Aa
hsp70, Hsp70A, hsp-70
Heat-shock-protein-70Ab
hsp70, Hsp70A, hsp-70
Heat-shock-protein-70Ba
hsp70, Hsp70B, hsp-70
Heat-shock-protein-70Bb
hsp70, Hsp70B, hsp-70, Hsp70Bc
Heat-shock-protein-70Bc
hsp70, Hsp70B, hsp-70
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Heat shock protein 83
Hsp90, hsp82, l(3)j5C2, E(sev)3A, E(sina)2
External Data
Other resource(s)
[Heat shock protein information resource](http://pdslab.biochem.iisc.ernet.in/hspir/index.php)
Synonyms and Secondary IDs
Synonym(s)
HSP
HEAT SHOCK PROTEINS
Secondary FlyBase ID(s)
References (16)
Review
Morrow et al., 2016, Biogerontology 17(1): 61--70
Drosophila melanogaster mitochondrial Hsp22: a role in resistance to oxidative stress, aging and the mitochondrial unfolding protein response. [FBrf0230737]
Arya et al., 2007, J. Biosci., Bangalore 32(3): 595--610
Heat shock genes - integrating cell survival and death. [FBrf0202368]
Michaud et al., 2002, Prog. molec. subcell. Biol. 28: 79--101
Drosophila small heat shock proteins: cell and organelle-specific chaperones? [FBrf0147191]
Research paper
Li et al., 2016, Gene 576(1): 88--98
Cloning and analysis of DnaJ family members in the silkworm, Bombyx mori. [FBrf0232267]
Vos et al., 2016, Aging Cell 15(2): 217--226
Specific protein homeostatic functions of small heat-shock proteins increase lifespan. [FBrf0231212]
Pantzartzi et al., 2013, PLoS ONE 8(9): e73217
Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. [FBrf0232266]
Monzo et al., 2010, Dev. Biol. 340(2): 408--418
Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila. [FBrf0210519]
Takahashi et al., 2010, BMC Evol. Biol. 10: 284
Effects of small Hsp genes on developmental stability and microenvironmental canalization. [FBrf0211941]
Li et al., 2009, BMC Evol. Biol. 9: 215
The small heat shock protein (sHSP) genes in the silkworm, Bombyx mori, and comparative analysis with other insect sHSP genes. [FBrf0232494]
Chen et al., 2006, BMC Genomics 7: 156
Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms. [FBrf0232231]
Morrow et al., 2006, Cell Stress Chaperones 11(1): 51--60
Differences in the chaperone-like activities of the four main small heat shock proteins of Drosophila melanogaster. [FBrf0189960]
Sarkar and Lakhotia, 2005, J. Genet. 84(3): 265--281
The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility. [FBrf0190982]
Nikolaidis and Nei, 2004, Mol. Biol. Evol. 21(3): 498--505
Concerted and nonconcerted evolution of the Hsp70 gene superfamily in two sibling species of nematodes. [FBrf0174945]
Easton et al., 2000, Cell Stress Chaperones 5(4): 276--290
The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s. [FBrf0232270]
FlyBase analysis
FlyBase, 2014-, FlyBase Gene Group information.
FlyBase Gene Group information. [FBrf0225556]
Website
Ratheesh et al., 2012, HSPIR: a manually annotated heat shock protein information resource.
HSPIR: a manually annotated heat shock protein information resource. [FBrf0232269]