FB2025_02 , released April 17, 2025
Gene Group: SMALL HEAT SHOCK PROTEINS
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General Information
Name
SMALL HEAT SHOCK PROTEINS
Species
D. melanogaster
Symbol
S-HSP
FlyBase ID
FBgg0000507
Date last reviewed
2016-04-21
Number of members
11
Description
Description
The small Heat Shock Protein (sHSP) family is characterized by the presence of an α-crystallin domain. sHSPs play a crucial role in protein folding. Most sHSPs have the ability to prevent protein aggregation and to maintain substrate proteins in a refoldable state. (Adapted from FBrf0228040 and FBrf0231212).
Notes on Group

FBrf0231212 reported that heat shock stimulates the transcription of all sHSPs with the exception of CG14207 and CG13133 in S2 cells.

CG4456 has been referred to as a (small) heat shock gene/protein in several publications but is omitted from this group because it displays atypical behaviour in response to heat-shock and the encoded protein lacks sequence/domain features characteristic of the family (FBrf0048582).

Source Material
The SMALL HEAT SHOCK PROTEINS Gene Group has been compiled using the following publication(s): Jagla et al., 2018, Vos et al., 2016, Takahashi et al., 2010, Li et al., 2009, Morrow et al., 2006, and Michaud et al., 2002 .
Key Gene Ontology (GO) terms
Molecular Function
Cellular Component
Related Gene Groups
Parent group(s)
Members (11)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)

[Heat shock protein information resource:sHsp ](http://pdslab.biochem.iisc.ernet.in/hspir/shsp.php)

Synonyms and Secondary IDs
Synonym(s)
S-HSP
SMALL HEAT SHOCK PROTEINS
sHSP
Secondary FlyBase ID(s)
References (7)