Gene Group: SMALL HEAT SHOCK PROTEINS

General Information

Name

SMALL HEAT SHOCK PROTEINS

Species

D. melanogaster

Symbol

S-HSP

FlyBase ID

FBgg0000507

Date last reviewed

2016-04-21

Number of members

Description

The small Heat Shock Protein (sHSP) family is characterized by the presence of an α-crystallin domain. sHSPs play a crucial role in protein folding. Most sHSPs have the ability to prevent protein aggregation and to maintain substrate proteins in a refoldable state. (Adapted from FBrf0228040 and FBrf0231212).

Notes on Group

FBrf0231212 reported that heat shock stimulates the transcription of all sHSPs with the exception of CG14207 and CG13133 in S2 cells.

CG4456 has been referred to as a (small) heat shock gene/protein in several publications but is omitted from this group because it displays atypical behaviour in response to heat-shock and the encoded protein lacks sequence/domain features characteristic of the family (FBrf0048582).

Source Material

The SMALL HEAT SHOCK PROTEINS Gene Group has been compiled using the following publication(s): Jagla et al., 2018, Vos et al., 2016, Takahashi et al., 2010, Li et al., 2009, Morrow et al., 2006, and Michaud et al., 2002 .

Key Gene Ontology (GO) terms

Molecular Function

unfolded protein binding

Biological Process

response to heat

protein folding

chaperone-mediated protein folding

Cellular Component

Related Gene Groups

Parent group(s)

HEAT SHOCK PROTEINS

Members (11)