General Information
Name
SPLICEOSOMAL COMPLEXES
Species
D. melanogaster
Symbol
SPL-C
FlyBase ID
FBgg0000519
Date last reviewed
2016-08-11
Number of members
146
Description
Description
Nuclear pre-mRNA splicing is catalyzed by the spliceosome. The spliceosome is composed of five small nuclear ribonucleoprotein complexes, along with many associated protein cofactors, that assemble to catalyze the removal of introns from pre-mRNA and the joining of exons to produce mature mRNA. (Adapted from PMID:23118483).
Notes on Group
The SPLICEOSOMAL COMPLEXES gene groups are largely based on sets downloaded from the Spliceosome Database (PMID:23118483, http://spliceosomedb.ucsc.edu/) on 19th June 2015.
Source Material
The SPLICEOSOMAL COMPLEXES Gene Group has been compiled by FlyBase curators using the following publication(s): Cvitkovic and Jurica, 2013, Herold et al., 2009, Lu and Matera, 2014, Saluz et al., 1988, and Rudner et al., 1998.
Key Gene Ontology (GO) terms
Molecular Function
Cellular Component
Related Gene Groups
Members (146)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
DEAH-box helicase 15
half pint
pUf68, pUbsf, DPUF68, PUF60
Heterogeneous nuclear ribonucleoprotein at 87F
hrp36, P11, hnRNPA1, hnRNPA2, Hrb87Fa
Heterogeneous nuclear ribonucleoprotein at 98DE
hrp38
noisette
l(3)j3E7, SF3A3
PHD finger protein 5a
SR-related CTD associated factor 6
BP1040
Splicing factor 3a subunit 1
Splicing factor 3a subunit 2
Splicing factor 3b subunit 1
Splicing factor 3b subunit 2
Splicing factor 3b subunit 3
Splicing factor 3b subunit 5
Splicing factor 3b subunit 6
Small ribonucleoprotein particle protein SmB
Sm B
Small ribonucleoprotein particle protein SmD1
snRNP69D
Small ribonucleoprotein particle protein SmD2
snRNP2
Small ribonucleoprotein particle protein SmD3
guf, l(2)90/37
Small ribonucleoprotein particle protein SmE
Small ribonucleoprotein particle protein SmF
DebB, Deb-B
sans fille
fs(1)1621, fs(1)A1621, liz, SNF/D25
small nuclear RNA U1 at 21D
U1, U1 snRNA, U1snRNA, U1-21.1, snRNA:U1
small nuclear RNA U1 at 82Eb
U1, U1 snRNA, U1snRNA, U1-82.3, U1:82Eb
small nuclear RNA U1 at 95Ca
U1, U1 snRNA, U1:95Ca, DMU1951, U1-95.1
small nuclear RNA U1 at 95Cb
U1, U1 snRNA, U1snRNA, U1:95Cb, U1-95.2
small nuclear RNA U1 at 95Cc
U1, U1 snRNA, U1snRNA, U1:95Cc, U1-95.3
small nuclear RNA U2 at 14B
U2 snRNA, U2, dU2, U2:14B, U2-14B
small nuclear RNA U2 at 34ABa
U2 snRNA, U2, dU2, U2:34ABa, U2-131A
small nuclear RNA U2 at 34ABb
U2 snRNA, U2, dU2, U2:34ABb, U2-131B
small nuclear RNA U2 at 34ABc
U2 snRNA, U2, dU2
small nuclear RNA U2 at 38ABa
U2 snRNA, U2, dU2, U2:38ABa, U2-141A
small nuclear RNA U2 at 38ABb
U2 snRNA, U2, dU2, U2:38ABb, U2-141B
small ribonucleoprotein particle U1 subunit 70K
U1-70K, snRNP70K, U1 snRNP, 70K, snRNP27D
small ribonucleoprotein particle U1 subunit C
snRNP-U1, U1C
Small nuclear ribonucleoprotein G
SmG
Spliceosomal protein on the X
squid
hrp40, l(3)j4B4, l(3)EP3631, Squid, RRM3
U2A
U2A', l(2)43Ee, dU2A'
U2 small nuclear riboprotein auxiliary factor 38
U2AF, dU2AF38, dU2AF38
U2 small nuclear riboprotein auxiliary factor 50
dU2AF50, U2AF, l(1)9-21, dU2AF50, l(1)14Cc
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cell division cycle 5
crooked neck
yok, l(1)2, EG:30B8.1, l30
DEAH-box helicase 15
lethal (1) 10Bb
l(1)G0169
Microfibril-associated protein 1
noisette
l(3)j3E7, SF3A3
PHD finger protein 5a
Precursor RNA processing 3
pre-mRNA processing factor 8
Pre-RNA processing factor 19
l(2)07838, Gbp
Pre-mRNA processing factor 31
pre-mRNA processing factor 38
Splicing factor 3a subunit 1
Splicing factor 3a subunit 2
Splicing factor 3b subunit 1
Splicing factor 3b subunit 2
Splicing factor 3b subunit 3
Splicing factor 3b subunit 5
Splicing factor 3b subunit 6
septin interacting protein 1
Small ribonucleoprotein particle protein SmB
Sm B
Small ribonucleoprotein particle protein SmD1
snRNP69D
Small ribonucleoprotein particle protein SmD2
snRNP2
Small ribonucleoprotein particle protein SmD3
guf, l(2)90/37
Small ribonucleoprotein particle protein SmE
Small ribonucleoprotein particle protein SmF
DebB, Deb-B
Smu1 spliceosomal factor
sans fille
fs(1)1621, fs(1)A1621, liz, SNF/D25
small nuclear RNA U1 at 21D
U1, U1 snRNA, U1snRNA, U1-21.1, snRNA:U1
small nuclear RNA U1 at 82Eb
U1, U1 snRNA, U1snRNA, U1-82.3, U1:82Eb
small nuclear RNA U1 at 95Ca
U1, U1 snRNA, U1:95Ca, DMU1951, U1-95.1
small nuclear RNA U1 at 95Cb
U1, U1 snRNA, U1snRNA, U1:95Cb, U1-95.2
small nuclear RNA U1 at 95Cc
U1, U1 snRNA, U1snRNA, U1:95Cc, U1-95.3
small nuclear RNA U2 at 14B
U2 snRNA, U2, dU2, U2:14B, U2-14B
small nuclear RNA U2 at 34ABa
U2 snRNA, U2, dU2, U2:34ABa, U2-131A
small nuclear RNA U2 at 34ABb
U2 snRNA, U2, dU2, U2:34ABb, U2-131B
small nuclear RNA U2 at 34ABc
U2 snRNA, U2, dU2
small nuclear RNA U2 at 38ABa
U2 snRNA, U2, dU2, U2:38ABa, U2-141A
small nuclear RNA U2 at 38ABb
U2 snRNA, U2, dU2, U2:38ABb, U2-141B
small nuclear RNA U4 at 38AB
U4, U4 snRNA, U4-1, U4:38AB
small nuclear RNA U4 at 39B
U4, U4 snRNA, U4-2, U4:39B, l(2)k09410
small nuclear RNA U5 at 14B
U5, U5 snRNA, U5:14B
small nuclear RNA U5 at 23DE
U5, U5 snRNA, U5:23D
small nuclear RNA U5 at 34AB
U5, U5 snRNA, U5:34A
small nuclear RNA U5 at 35EF
U5, U5 snRNA, U5:35D
snRNA:U5:38ABa
U5, U5 snRNA, U5:38ABa
snRNA:U5:38ABb
U5, U5 snRNA, U5:38ABb
small nuclear RNA U5 at 63A
U5, U5:63BC, U5 snRNA
small nuclear RNA U6 at 96Aa
U6, U6-1, U6 snRNA, U6 RNA, snRNA-b
small nuclear RNA U6 at 96Ab
U6, U6-2, U6 RNA, U6 snRNA, U6:96Ab
small nuclear RNA U6 at 96Ac
U6, U6 snRNA, U6 RNA, U6-3, snRNA-b
small ribonucleoprotein particle U1 subunit 70K
U1-70K, snRNP70K, U1 snRNP, 70K, snRNP27D
small ribonucleoprotein particle U1 subunit C
snRNP-U1, U1C
Small nuclear ribonucleoprotein G
SmG
Spliceosomal protein on the X
Transport and Golgi organization 4
U2A
U2A', l(2)43Ee, dU2A'
U4-U6 small nuclear riboprotein factor 60K
Ubiquitin specific protease 39
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Bicoid interacting protein 1
dSAP18, SAP18
Cdc2-related kinase
Dcdrk
Cell division cycle 5
crooked neck
yok, l(1)2, EG:30B8.1, l30
Heat shock protein cognate 1
Hsc70, Hsc1
lethal (1) 10Bb
l(1)G0169
lethal (2) 37Cb
l(2)E104, Cb
mago nashi
mgn, l(2)57Ca
noisette
l(3)j3E7, SF3A3
PHD finger protein 5a
pre-mRNA processing factor 8
Pre-RNA processing factor 19
l(2)07838, Gbp
Splicing factor 3a subunit 1
Splicing factor 3a subunit 2
Splicing factor 3b subunit 1
Splicing factor 3b subunit 2
Splicing factor 3b subunit 3
Splicing factor 3b subunit 5
Splicing factor 3b subunit 6
Small ribonucleoprotein particle protein SmB
Sm B
Small ribonucleoprotein particle protein SmD1
snRNP69D
Small ribonucleoprotein particle protein SmD2
snRNP2
Small ribonucleoprotein particle protein SmD3
guf, l(2)90/37
Small ribonucleoprotein particle protein SmE
Small ribonucleoprotein particle protein SmF
DebB, Deb-B
small nuclear RNA U2 at 14B
U2 snRNA, U2, dU2, U2:14B, U2-14B
small nuclear RNA U2 at 34ABa
U2 snRNA, U2, dU2, U2:34ABa, U2-131A
small nuclear RNA U2 at 34ABb
U2 snRNA, U2, dU2, U2:34ABb, U2-131B
small nuclear RNA U2 at 34ABc
U2 snRNA, U2, dU2
small nuclear RNA U2 at 38ABa
U2 snRNA, U2, dU2, U2:38ABa, U2-141A
small nuclear RNA U2 at 38ABb
U2 snRNA, U2, dU2, U2:38ABb, U2-141B
small nuclear RNA U5 at 14B
U5, U5 snRNA, U5:14B
small nuclear RNA U5 at 23DE
U5, U5 snRNA, U5:23D
small nuclear RNA U5 at 34AB
U5, U5 snRNA, U5:34A
small nuclear RNA U5 at 35EF
U5, U5 snRNA, U5:35D
snRNA:U5:38ABa
U5, U5 snRNA, U5:38ABa
snRNA:U5:38ABb
U5, U5 snRNA, U5:38ABb
small nuclear RNA U5 at 63A
U5, U5:63BC, U5 snRNA
small nuclear RNA U6 at 96Aa
U6, U6-1, U6 snRNA, U6 RNA, snRNA-b
small nuclear RNA U6 at 96Ab
U6, U6-2, U6 RNA, U6 snRNA, U6:96Ab
small nuclear RNA U6 at 96Ac
U6, U6 snRNA, U6 RNA, U6-3, snRNA-b
Small nuclear ribonucleoprotein G
SmG
Spliceosomal protein on the X
Transport and Golgi organization 4
tsunagi
Y14, Y14/Tsunagi
U2A
U2A', l(2)43Ee, dU2A'
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cdc2-related kinase
Dcdrk
Cell division cycle 5
crooked neck
yok, l(1)2, EG:30B8.1, l30
Heat shock protein cognate 1
Hsc70, Hsc1
lethal (1) 10Bb
l(1)G0169
lethal (2) 37Cb
l(2)E104, Cb
mago nashi
mgn, l(2)57Ca
noisette
l(3)j3E7, SF3A3
PHD finger protein 5a
pre-mRNA processing factor 8
Pre-RNA processing factor 19
l(2)07838, Gbp
Splicing factor 3a subunit 1
Splicing factor 3a subunit 2
Splicing factor 3b subunit 1
Splicing factor 3b subunit 2
Splicing factor 3b subunit 3
Splicing factor 3b subunit 5
Splicing factor 3b subunit 6
Small ribonucleoprotein particle protein SmB
Sm B
Small ribonucleoprotein particle protein SmD1
snRNP69D
Small ribonucleoprotein particle protein SmD2
snRNP2
Small ribonucleoprotein particle protein SmD3
guf, l(2)90/37
Small ribonucleoprotein particle protein SmE
Small ribonucleoprotein particle protein SmF
DebB, Deb-B
small nuclear RNA U2 at 14B
U2 snRNA, U2, dU2, U2:14B, U2-14B
small nuclear RNA U2 at 34ABa
U2 snRNA, U2, dU2, U2:34ABa, U2-131A
small nuclear RNA U2 at 34ABb
U2 snRNA, U2, dU2, U2:34ABb, U2-131B
small nuclear RNA U2 at 34ABc
U2 snRNA, U2, dU2
small nuclear RNA U2 at 38ABa
U2 snRNA, U2, dU2, U2:38ABa, U2-141A
small nuclear RNA U2 at 38ABb
U2 snRNA, U2, dU2, U2:38ABb, U2-141B
small nuclear RNA U5 at 14B
U5, U5 snRNA, U5:14B
small nuclear RNA U5 at 23DE
U5, U5 snRNA, U5:23D
small nuclear RNA U5 at 34AB
U5, U5 snRNA, U5:34A
small nuclear RNA U5 at 35EF
U5, U5 snRNA, U5:35D
snRNA:U5:38ABa
U5, U5 snRNA, U5:38ABa
snRNA:U5:38ABb
U5, U5 snRNA, U5:38ABb
small nuclear RNA U5 at 63A
U5, U5:63BC, U5 snRNA
small nuclear RNA U6 at 96Aa
U6, U6-1, U6 snRNA, U6 RNA, snRNA-b
small nuclear RNA U6 at 96Ab
U6, U6-2, U6 RNA, U6 snRNA, U6:96Ab
small nuclear RNA U6 at 96Ac
U6, U6 snRNA, U6 RNA, U6-3, snRNA-b
Small nuclear ribonucleoprotein G
SmG
Spliceosomal protein on the X
Transport and Golgi organization 4
tsunagi
Y14, Y14/Tsunagi
U2A
U2A', l(2)43Ee, dU2A'
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Small ribonucleoprotein particle protein SmB
Sm B
Small ribonucleoprotein particle protein SmD1
snRNP69D
Small ribonucleoprotein particle protein SmD2
snRNP2
Small ribonucleoprotein particle protein SmD3
guf, l(2)90/37
Small ribonucleoprotein particle protein SmE
Small ribonucleoprotein particle protein SmF
DebB, Deb-B
sans fille
fs(1)1621, fs(1)A1621, liz, SNF/D25
small nuclear RNA U1 at 21D
U1, U1 snRNA, U1snRNA, U1-21.1, snRNA:U1
small nuclear RNA U1 at 82Eb
U1, U1 snRNA, U1snRNA, U1-82.3, U1:82Eb
small nuclear RNA U1 at 95Ca
U1, U1 snRNA, U1:95Ca, DMU1951, U1-95.1
small nuclear RNA U1 at 95Cb
U1, U1 snRNA, U1snRNA, U1:95Cb, U1-95.2
small nuclear RNA U1 at 95Cc
U1, U1 snRNA, U1snRNA, U1:95Cc, U1-95.3
small ribonucleoprotein particle U1 subunit 70K
U1-70K, snRNP70K, U1 snRNP, 70K, snRNP27D
small ribonucleoprotein particle U1 subunit C
snRNP-U1, U1C
Small nuclear ribonucleoprotein G
SmG
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Small ribonucleoprotein particle protein SmB
Sm B
Small ribonucleoprotein particle protein SmD1
snRNP69D
Small ribonucleoprotein particle protein SmD2
snRNP2
Small ribonucleoprotein particle protein SmD3
guf, l(2)90/37
Small ribonucleoprotein particle protein SmE
Small ribonucleoprotein particle protein SmF
DebB, Deb-B
sans fille
fs(1)1621, fs(1)A1621, liz, SNF/D25
small nuclear RNA U2 at 14B
U2 snRNA, U2, dU2, U2:14B, U2-14B
small nuclear RNA U2 at 34ABa
U2 snRNA, U2, dU2, U2:34ABa, U2-131A
small nuclear RNA U2 at 34ABb
U2 snRNA, U2, dU2, U2:34ABb, U2-131B
small nuclear RNA U2 at 34ABc
U2 snRNA, U2, dU2
small nuclear RNA U2 at 38ABa
U2 snRNA, U2, dU2, U2:38ABa, U2-141A
small nuclear RNA U2 at 38ABb
U2 snRNA, U2, dU2, U2:38ABb, U2-141B
Small nuclear ribonucleoprotein G
SmG
Spliceosomal protein on the X
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
U2 small nuclear riboprotein auxiliary factor 38
U2AF, dU2AF38, dU2AF38
U2 small nuclear riboprotein auxiliary factor 50
dU2AF50, U2AF, l(1)9-21, dU2AF50, l(1)14Cc
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Precursor RNA processing 3
Pre-mRNA processing factor 31
Small ribonucleoprotein particle protein SmB
Sm B
Small ribonucleoprotein particle protein SmD1
snRNP69D
Small ribonucleoprotein particle protein SmD2
snRNP2
Small ribonucleoprotein particle protein SmD3
guf, l(2)90/37
Small ribonucleoprotein particle protein SmE
Small ribonucleoprotein particle protein SmF
DebB, Deb-B
snRNA:U4:25F
U4, U4 snRNA, U4-25F
small nuclear RNA U4 at 38AB
U4, U4 snRNA, U4-1, U4:38AB
small nuclear RNA U4 at 39B
U4, U4 snRNA, U4-2, U4:39B, l(2)k09410
small nuclear RNA U6 at 96Aa
U6, U6-1, U6 snRNA, U6 RNA, snRNA-b
small nuclear RNA U6 at 96Ab
U6, U6-2, U6 RNA, U6 snRNA, U6:96Ab
small nuclear RNA U6 at 96Ac
U6, U6 snRNA, U6 RNA, U6-3, snRNA-b
Small nuclear ribonucleoprotein G
SmG
U4-U6 small nuclear riboprotein factor 60K
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Precursor RNA processing 3
pre-mRNA processing factor 8
Pre-mRNA processing factor 31
Small ribonucleoprotein particle protein SmB
Sm B
Small ribonucleoprotein particle protein SmD1
snRNP69D
Small ribonucleoprotein particle protein SmD2
snRNP2
Small ribonucleoprotein particle protein SmD3
guf, l(2)90/37
Small ribonucleoprotein particle protein SmE
Small ribonucleoprotein particle protein SmF
DebB, Deb-B
small nuclear RNA U4 at 38AB
U4, U4 snRNA, U4-1, U4:38AB
small nuclear RNA U4 at 39B
U4, U4 snRNA, U4-2, U4:39B, l(2)k09410
small nuclear RNA U5 at 14B
U5, U5 snRNA, U5:14B
small nuclear RNA U5 at 23DE
U5, U5 snRNA, U5:23D
small nuclear RNA U5 at 34AB
U5, U5 snRNA, U5:34A
small nuclear RNA U5 at 35EF
U5, U5 snRNA, U5:35D
snRNA:U5:38ABa
U5, U5 snRNA, U5:38ABa
snRNA:U5:38ABb
U5, U5 snRNA, U5:38ABb
small nuclear RNA U5 at 63A
U5, U5:63BC, U5 snRNA
small nuclear RNA U6 at 96Aa
U6, U6-1, U6 snRNA, U6 RNA, snRNA-b
small nuclear RNA U6 at 96Ab
U6, U6-2, U6 RNA, U6 snRNA, U6:96Ab
small nuclear RNA U6 at 96Ac
U6, U6 snRNA, U6 RNA, U6-3, snRNA-b
Small nuclear ribonucleoprotein G
SmG
U4-U6 small nuclear riboprotein factor 60K
Ubiquitin specific protease 39
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Small ribonucleoprotein particle protein SmB
Sm B
Small ribonucleoprotein particle protein SmD1
snRNP69D
Small ribonucleoprotein particle protein SmD2
snRNP2
Small ribonucleoprotein particle protein SmD3
guf, l(2)90/37
Small ribonucleoprotein particle protein SmE
Small ribonucleoprotein particle protein SmF
DebB, Deb-B
small nuclear RNA U5 at 14B
U5, U5 snRNA, U5:14B
small nuclear RNA U5 at 23DE
U5, U5 snRNA, U5:23D
small nuclear RNA U5 at 34AB
U5, U5 snRNA, U5:34A
small nuclear RNA U5 at 35EF
U5, U5 snRNA, U5:35D
snRNA:U5:38ABa
U5, U5 snRNA, U5:38ABa
snRNA:U5:38ABb
U5, U5 snRNA, U5:38ABb
small nuclear RNA U5 at 63A
U5, U5:63BC, U5 snRNA
Small nuclear ribonucleoprotein G
SmG
External Data
Equivalent Group(s)
Other resource(s)
[Spliceosome Database](http://spliceosomedb.ucsc.edu)
Synonyms and Secondary IDs
Synonym(s)
SPL-C
SPLICEOSOMAL COMPLEXES
Spliceosome
Secondary FlyBase ID(s)
References (6)
FlyBase analysis
FlyBase, 2014-, FlyBase Gene Group information.
FlyBase Gene Group information. [FBrf0225556]
Research paper
Lu and Matera, 2014, G3 (Bethesda) 5(1): 103--110
Developmental Analysis of Spliceosomal snRNA Isoform Expression. [FBrf0227312]
Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172]
Rudner et al., 1998, Mol. Cell. Biol. 18(7): 4004--4011
RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding. [FBrf0103091]
Saluz et al., 1988, Nucleic Acids Res. 16(8): 3582
The localization and estimated copy number of Drosophila melanogaster U1, U4, U5 and U6 snRNA genes. [FBrf0048816]
Website
Cvitkovic and Jurica, 2013, Spliceosome Database.
Spliceosome Database. [FBrf0233108]