General Information
Name
NONASPANINS
Species
D. melanogaster
Symbol
TM9SF
FlyBase ID
FBgg0000531
Date last reviewed
2016-07-04
Number of members
3
Description
Description
Nonaspanins (Transmembrane 9 superfamily) are a family of conserved proteins characterized by a large N-terminal extracellular domain and nine putative transmembrane domains. Nonaspanins are largely uncharacterized, but some members have been implicated in the innate immune response. (Adapted from FBrf0227121, FBrf0232789 and FBrf0206066).
Notes on Group
Source Material
The NONASPANINS Gene Group has been compiled by FlyBase curators using the following publication(s): Pruvot et al., 2010, Bergeret et al., 2008, and Perrin et al., 2015.
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Members (3)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Transmembrane 9 superfamily protein member 2
38E.10
Transmembrane 9 superfamily protein member 3
Transmembrane 9 superfamily protein member 4
BG:DS00797.1, n(2)k07245
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TM9SF
NONASPANINS
Transmembrane 9 superfamily
TM9
Secondary FlyBase ID(s)
References (4)
Research paper
Perrin et al., 2015, J. Innate Immun. 7(1): 37--46
The Nonaspanins TM9SF2 and TM9SF4 Regulate the Plasma Membrane Localization and Signalling Activity of the Peptidoglycan Recognition Protein PGRP-LC in Drosophila. [FBrf0227121]
Pruvot et al., 2010, Immunogenetics 62(10): 681--699
Comparative analysis of nonaspanin protein sequences and expression studies in zebrafish. [FBrf0232789]
Bergeret et al., 2008, J. Cell Sci. 121(20): 3325--3334
TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis. [FBrf0206066]
FlyBase analysis
FlyBase, 2014-, FlyBase Gene Group information.
FlyBase Gene Group information. [FBrf0225556]