General Information
D. melanogaster
FlyBase ID
Date last reviewed
Number of members
Tetraspanins (TSP) have four transmembrane domains and two extracellular loops containing specific short motifs, including highly conserved cysteine residues. TSPs are thought to function as scaffolds that bring multiple proteins - including other TSPs, membrane-associated proteins, extracellular and cytosolic proteins - into single membrane region. These regions are called tetraspanin-enriched microdomains. (Adapted from FBrf0227776 and FBrf0152316).
Notes on Group
CG30160 is included in the TETRASPANINS gene group as it is a tandem duplicate of Tsp42Eb (FBrf0206967) and is identical within the coding region.
In FBrf0132356, CG31600 is reported as a Tetraspanin, although its sequence is highly divergent to other members, it possesses a four predicted transmembrane regions and is therefore tentatively included in the TETRASPANINS gene group.
Source Material
The TETRASPANINS Gene Group has been compiled by FlyBase curators using the following publication(s): Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Zhou et al., 2008, and Todres et al., 2000.
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Related Gene Groups
Other related group(s)
Members (38)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
External Data
Synonyms and Secondary IDs
Transmembrane 4 superfamily
Secondary FlyBase ID(s)
References (6)
Research paper
Fox and Andrew, 2015, Biol. Open 4(3): 317--330
Changes in organelle position and epithelial architecture associated with loss of CrebA. [FBrf0227776]
Jeibmann et al., 2015, J. Neurooncol. 124(3): 373--383
Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. [FBrf0229657]
Zhou et al., 2008, Genome Res. 18(9): 1446--1455
On the origin of new genes in Drosophila. [FBrf0206967]
Fradkin et al., 2002, Proc. Natl. Acad. Sci. U.S.A. 99(21): 13663--13668
Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. [FBrf0152316]
Todres et al., 2000, Insect Mol. Biol. 9(6): 581--590
The tetraspanin superfamily in insects. [FBrf0132356]
FlyBase analysis
FlyBase, 2014-, FlyBase Gene Group information.
FlyBase Gene Group information. [FBrf0225556]