The Chloride intracellular channel (CLIC) family exists as soluble globular proteins and have been shown to form ion channels in artificial bilayers. CLIC proteins are characterised by the presence of a 240 residue CLIC module, whose structure belongs to the GST-fold superfamily. (Adapted from FBrf0204349 and FBrf0232068).
The INTRACELLULAR CHLORIDE CHANNEL SUBUNITS gene group contains only one member.
It should be noted that the INTRACELLULAR CHLORIDE CHANNEL SUBUNITS represent a group related by sequence/structural features. There are other chloride channels that mediate the transmembrane transport of chloride ions in intracellular compartments within subgroups of the CHLORIDE CHANNEL SUBUNITS gene group.