General Information
D. melanogaster
FlyBase ID
Date last reviewed
Number of members
Ion channels selectively gate the flow of ions across cellular membranes. (Adapted from FBrf0193525).
Notes on Group
Source Material
The ION CHANNELS Gene Group has been compiled by FlyBase curators using the following publication(s): Döring et al., 2006, Buckingham et al., 2005, Chintapalli et al., 2013, Benton et al., 2009, Croset et al., 2010, Croset et al., 2010, Robertson et al., 2003, Robertson, 2009, Warr et al., 2000, Lee et al., 2009, Liu et al., 2016, Xia et al., 2005, Tomita et al., 2015, Chorna and Hasan, 2012, Ben-Shahar, 2011, Ben-Shahar, 2012.2.9, Zelle et al., 2013, Littleton and Ganetzky, 2000, Sattelle et al., 2005, Dupuis et al., 2012, Hartzell et al., 2008, Tavsanli et al., 2001, Chien and Hartzell, 2007, Voets and Nilius, 2003, Montell, 2005, Fowler and Montell, 2013, Matsuura et al., 2009, Venkatachalam et al., 2014, Cooper et al., 2010, Salkoff et al., 2006, Frolov et al., 2012, McCormack, 2003, Huang et al., 2014, Doring et al., 2002, Wu et al., 2015, Luan and Li, 2012, Gisselmann et al., 2005, Hu et al., 2015, Chen and Wang, 2012, Knipple and Soderlund, 2010, Remnant et al., 2016, Schnizler et al., 2005, Cully et al., 1996, Ashburner et al., 1999.10.12, Galindo and Vacquier, 2005, Jang et al., 2015, Wong et al., 2013, Gisselmann et al., 2002, Charroux and Royet, 2014, Suzuki, 2006, Feingold et al., 2016, Rose et al., 2007, Dow and Davies, 2003, Cabrero et al., 2014, Saha et al., 2015, Pantazis et al., 2008, Gisselmann et al., 2004, Bhandari et al., 2012, Littler et al., 2008, Littler et al., 2010, Ljaschenko et al., 2013, Han et al., 2015, Li et al., 2011, Wang et al., 2015, Zhang et al., 2011, Coste et al., 2012, Coste et al., 2015, Murmu and Martin, 2016, Murmu et al., 2010, Yao et al., 2009, Dong et al., 2015, Zhang et al., 2013, Gosselin-Badaroudine et al., 2016, Saras and Tanouye, 2016, Kanamori et al., 2013, Ly et al., 2008, Stathopulos and Ikura, 2013, Zhang et al., 2006, Gwack et al., 2007, and Smyth et al., 2010.
Key Gene Ontology (GO) terms
Biological Process
Related Gene Groups
Members (270)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Chloride intracellular channel
l(1)G0472, l(1)G0053, DmCLIC
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Inwardly rectifying potassium channel 1
Ir, Dm_3R:100349, Dm_3R:100326
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
nicotinic Acetylcholine Receptor α1
ALS, nAcRalpha-96Aa, Dα1, nAcRα-96Aa, Acr96Aa
nicotinic Acetylcholine Receptor α2
Dα2, SAD, nAcRα-96Ab, Da2, nAcRalpha-96Ab
nicotinic Acetylcholine Receptor α3
Dα3, nACRalpha-7E, nAcRα-7E, nAChR, lincRNA.965
nicotinic Acetylcholine Receptor α4
Dα4, nAcRalpha-80B, nAcRα-80B, nAChR, Dalpha4
nicotinic Acetylcholine Receptor α5
Dα5, BG:DS05899.4, nAcRα-34E, nAcRalpha-34E, BG:DS05899.5
nicotinic Acetylcholine Receptor α6
Dα6, nAcRα-30D, nAcRalpha-30D, rsn, nAChR
nicotinic Acetylcholine Receptor α7
Dα7, gfA, nAcRα-18C, nAChR
nicotinic Acetylcholine Receptor β1
ARD, nAcRβ-64B, Dβ1, nAcRbeta-64B, nAChR
nicotinic Acetylcholine Receptor β2
SBD, Dβ2, nAcRbeta-96A, nAcRβ-96A, nAChR
nicotinic Acetylcholine Receptor β3
nAcRβ-21C, Dβ3, nAChR, nAcRbeta-21C
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Odorant receptor 2a
AN4, EG:30B8.7
Odorant receptor 19b
Odorant receptor 22a
AN11, Dor53, 22A.1, DOR22a
Odorant receptor 22b
AN12, DOR22A.2, 22A.2, Dor67
Odorant receptor 35a
35a, BG:BACR44L22.5
Odorant receptor 46a
Or46aA, Or46b, Or46aB, AN9, AN8
Odorant receptor 47a
AN10, 47a, DOR24
Odorant receptor 67d
Odorant receptor 69a
Or69b, Or69aA, Or69aB
Odorant receptor co-receptor
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Inositol 1,4,5,-tris-phosphate receptor
itpr, IP3R, InsP3R, IP3R, dip
Ryanodine receptor
Rya-r44F, l(2)k04913, DRR, dry
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Golgi pH Regulator
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ppk1, dmdNaC1, BG:DS06238.1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
small conductance calcium-activated potassium channel
slowpoke 2
Dm_2R:24438, Dm_2R:24301
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Transient receptor potential cation channel A1
dTrpA1, dANKTM1, TrpA, DmTRPA1
Transient receptor potential cation channel, mucolipin
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Ca2+-channel protein α1 subunit D
Dmca1D, l(2)35Fa, Caα1D, Ca-α1, BG:DS02795.1
Ca2+-channel protein α1 subunit T
2δ-3, α2δ
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Dm_X:51771, lincRNA.975, Hyperkinetic
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
bss, sbl, olfD, DmNav, DmNav1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
temperature-induced paralytic E
External Data
Other resource(s)
Synonyms and Secondary IDs
Secondary FlyBase ID(s)
References (81)
Research paper
Feingold et al., 2016, J. Exp. Biol. 219(17): 2629--2638
The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules. [FBrf0233346]
Gosselin-Badaroudine et al., 2016, J. Gen. Physiol. 148(2): 133--145
Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: CaV4. [FBrf0233871]
Liu et al., 2016, Cell 165(6): 1347--1360
Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit. [FBrf0232501]
Murmu and Martin, 2016, Biochim. Biophys. Acta 1863(9): 2156--2174
Interaction between cAMP and intracellular Ca(2+)-signaling pathways during odor-perception and adaptation in Drosophila. [FBrf0232841]
Remnant et al., 2016, G3 (Bethesda) 6(7): 2003--2012
Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster. [FBrf0232805]
Saras and Tanouye, 2016, PLoS Genet. 12(1): e1005784
Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila. [FBrf0230696]
Coste et al., 2015, Nat. Commun. 6: 7223
Piezo1 ion channel pore properties are dictated by C-terminal region. [FBrf0231881]
Han et al., 2015, Proc. Natl. Acad. Sci. U.S.A. 112(19): 6182--6187
Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors. [FBrf0228432]
Hu et al., 2015, PLoS Biol. 13(4): e1002115
Ih channels control feedback regulation from amacrine cells to photoreceptors. [FBrf0227998]
Jang et al., 2015, J. Biol. Chem. 290(4): 2521--2528
The anoctamin family channel subdued mediates thermal nociception in Drosophila. [FBrf0227430]
Saha et al., 2015, Nat. Nanotechnol. 10(7): 645--651
A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells. [FBrf0228900]
Tomita et al., 2015, PLoS ONE 10(5): e0128101
The NMDA Receptor Promotes Sleep in the Fruit Fly, Drosophila melanogaster. [FBrf0228555]
Wang et al., 2015, Insect Biochem. Mol. Biol. 60: 24--32
Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants. [FBrf0228338]
Wu et al., 2015, Am. J. Physiol. R., Regul. Integr. Comp. Physiol. 309(7): R747--R756
Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function. [FBrf0229719]
Cabrero et al., 2014, Proc. Natl. Acad. Sci. U.S.A. 111(39): 14301--14306
Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. [FBrf0226428]
Charroux and Royet, 2014, Biol. Open 3(1): 72--80
Mutations in the Drosophila ortholog of the vertebrate Golgi pH regulator (GPHR) protein disturb endoplasmic reticulum and Golgi organization and affect systemic growth. [FBrf0223802]
Huang et al., 2014, J. Mol. Neurosci. 53(1): 41--49
Evolutionary analysis of voltage-gated potassium channels by bayes method. [FBrf0224790]
Chintapalli et al., 2013, BMC Genomics 14: 518
Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia. [FBrf0222336]
Kanamori et al., 2013, Science 340(6139): 1475--1478
Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons. [FBrf0221870]
Ljaschenko et al., 2013, Cell Rep. 3(5): 1407--1413
Hebbian plasticity guides maturation of glutamate receptor fields in vivo. [FBrf0221724]
Wong et al., 2013, eLife 2(0): e00862
Subdued, a TMEM16 family Ca2+-activated Cl- channel in Drosophila melanogaster with an unexpected role in host defense. [FBrf0223235]
Zelle et al., 2013, G3 (Bethesda) 3(3): 441--450
The genetic architecture of degenerin/epithelial sodium channels in Drosophila. [FBrf0220901]
Zhang et al., 2013, PLoS Genet. 9(3): e1003327
Role of the DSC1 Channel in Regulating Neuronal Excitability in Drosophila melanogaster: Extending Nervous System Stability under Stress. [FBrf0221058]
Bhandari et al., 2012, Genes Brain Behav. 11(4): 387--397
Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. [FBrf0218558]
Chen and Wang, 2012, Sci. China Life Sci. 55(1): 2--7
Functional study of hyperpolarization activated channel (I ( h )) in Drosophila behavior. [FBrf0217396]
Coste et al., 2012, Nature 483(7388): 176--181
Piezo proteins are pore-forming subunits of mechanically activated channels. [FBrf0217754]
Li et al., 2011, BMC Evol. Biol. 11: 337
A remarkably stable TipE gene cluster: evolution of insect Para sodium channel auxiliary subunits. [FBrf0217002]
Zhang et al., 2011, Insect Biochem. Mol. Biol. 41(7): 451--458
Molecular characterization and functional expression of the DSC1 channel. [FBrf0213974]
Cooper et al., 2010, Genetics 185(3): 811--822
Molecular Genetic Analysis of Chd3 and Polytene Chromosome Region 76B-D in Drosophila melanogaster. [FBrf0211329]
Croset et al., 2010, PLoS Genet. 6(8): e1001064
Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. [FBrf0211681]
Murmu et al., 2010, J. Exp. Biol. 213(24): 4163--4173
Presynaptic Ca2+ stores contribute to odor-induced responses in Drosophila olfactory receptor neurons. [FBrf0212393]
Benton et al., 2009, Cell 136(1): 149--162
Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. [FBrf0206496]
Lee et al., 2009, Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 150(4): 546--557
Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. [FBrf0209026]
Matsuura et al., 2009, BMC Evol. Biol. 9: 228
Evolutionary conservation and changes in insect TRP channels. [FBrf0209017]
Robertson, 2009, J. Insect Sci. 9: 18
The insect chemoreceptor superfamily in Drosophila pseudoobscura: molecular evolution of ecologically-relevant genes over 25 million years. [FBrf0208421]
Yao et al., 2009, Cell 138(5): 947--960
A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. [FBrf0209490]
Littler et al., 2008, Proteins 71(1): 364--378
Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC. [FBrf0204349]
Ly et al., 2008, J. Cell Biol. 181(1): 157--170
straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. [FBrf0204125]
Pantazis et al., 2008, J. Neurosci. 28(29): 7250--7259
Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse. [FBrf0205744]
Chien and Hartzell, 2007, J. Gen. Physiol. 130(5): 513--524
Drosophila bestrophin-1 chloride current is dually regulated by calcium and cell volume. [FBrf0202001]
Gwack et al., 2007, J. Biol. Chem. 282(22): 16232--16243
Biochemical and functional characterization of Orai proteins. [FBrf0201325]
Rose et al., 2007, J. Exp. Biol. 210(14): 2489--2500
Properties and possible function of a hyperpolarisation-activated chloride current in Drosophila. [FBrf0202184]
Döring et al., 2006, Europ. J. Neurosci. 24(8): 2264--2274
Novel Drosophila two-pore domain K+ channels: rescue of channel function by heteromeric assembly. [FBrf0192007]
Suzuki, 2006, Exp. Physiol. 91(1): 141--147
The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels. [FBrf0192351]
Zhang et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(24): 9357--9362
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. [FBrf0194902]
Gisselmann et al., 2005, Insect Biochem. Mol. Biol. 35(5): 505--514
Variants of the Drosophila melanogaster I(h)-channel are generated by different splicing. [FBrf0184031]
Schnizler et al., 2005, J. Biol. Chem. 280(16): 16254--16262
A novel chloride channel in Drosophila melanogaster is inhibited by protons. [FBrf0187801]
Xia et al., 2005, Curr. Biol. 15(7): 603--615
NMDA receptors mediate olfactory learning and memory in Drosophila. [FBrf0187341]
Gisselmann et al., 2004, Neurosci. Lett. 372(1-2): 151--156
Unusual functional properties of homo- and heteromultimeric histamine-gated chloride channels of Drosophila melanogaster: spontaneous currents and dual gating by GABA and histamine. [FBrf0180587]
McCormack, 2003, Genome Biol. 4(9): R58
Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. [FBrf0162165]
Robertson et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100(Supplement 2): 14537--14542
Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. [FBrf0168007]
Doring et al., 2002, J. Biol. Chem. 277(28): 25554--25561
Inwardly rectifying K+ (Kir) channels in Drosophila. A crucial role of cellular milieu factors for Kir channel function. [FBrf0150787]
Gisselmann et al., 2002, Nat. Neurosci. 5(1): 11--12
Two cDNAs coding for histamine-gated ion channels in D. melanogaster. [FBrf0141682]
Tavsanli et al., 2001, genesis 31(3): 130--136
Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity. [FBrf0141766]
Littleton and Ganetzky, 2000, Neuron 26(1): 35--43
Ion channels and synaptic organization: analysis of the Drosophila genome. [FBrf0127201]
Cully et al., 1996, J. Biol. Chem. 271(33): 20187--20191
Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. [FBrf0089625]
Dong et al., 2015, Pestic. Biochem. Physiol. 120: 36--39
The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. [FBrf0228564]
Venkatachalam et al., 2014, Handb. Exp. Pharmacol. 223: 937--962
Evolutionarily Conserved, Multitasking TRP Channels: Lessons from Worms and Flies. [FBrf0225477]
Fowler and Montell, 2013, Life Sci. 92(8-9): 394--403
Drosophila TRP channels and animal behavior. [FBrf0220930]
Stathopulos and Ikura, 2013, Channels 7(5): 344--353
Structural aspects of calcium-release activated calcium channel function. [FBrf0226124]
Chorna and Hasan, 2012, Biochim. Biophys. Acta 1820(8): 1269--1282
The genetics of calcium signaling in Drosophila melanogaster. [FBrf0218524]
Dupuis et al., 2012, Neurosci. Biobehav. Rev. 36(6): 1553--1564
Insights from honeybee (Apis mellifera) and fly (Drosophila melanogaster) nicotinic acetylcholine receptors: From genes to behavioral functions. [FBrf0218556]
Frolov et al., 2012, J. Neurogenet. 26(3-4): 275--290
Potassium channels in Drosophila: historical breakthroughs, significance, and perspectives. [FBrf0220575]
Luan and Li, 2012, Sheng Li Xue Bao 64(5): 515--519
Inwardly rectifying potassium channels in Drosophila. [FBrf0219718]
Ben-Shahar, 2011, Adv. Genet. 76: 1--26
Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). [FBrf0218999]
Knipple and Soderlund, 2010, Pestic. Biochem. Physiol. 97(2): 140--148
The ligand-gated chloride channel gene family of Drosophila melanogaster. [FBrf0232136]
Littler et al., 2010, FEBS Lett. 584(10): 2093--2101
The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins? [FBrf0232068]
Smyth et al., 2010, J. Cell. Mol. Med. 14(10): 2337--2349
Activation and regulation of store-operated calcium entry. [FBrf0214207]
Hartzell et al., 2008, Physiol. Rev. 88(2): 639--672
Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. [FBrf0228651]
Salkoff et al., 2006, Nat. Rev. Neurosci. 7(12): 921--931
High-conductance potassium channels of the SLO family. [FBrf0193525]
Buckingham et al., 2005, Trends Pharmacol. Sci. 26(7): 361--367
Structure and function of two-pore-domain K+ channels: contributions from genetic model organisms. [FBrf0188365]
Galindo and Vacquier, 2005, Int. J. Mol. Med. 16(5): 919--924
Phylogeny of the TMEM16 protein family: some members are overexpressed in cancer. [FBrf0190859]
Montell, 2005, Pflugers Arch. 451(1): 19--28
Drosophila TRP channels. [FBrf0191401]
Sattelle et al., 2005, BioEssays 27(4): 366--376
Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster. [FBrf0183743]
Dow and Davies, 2003, Physiol. Rev. 83(3): 687--729
Integrative physiology and functional genomics of epithelial function in a genetic model organism. [FBrf0160493]
Voets and Nilius, 2003, J. Membrane Biol. 192(1): 1--8
TRPs make sense. [FBrf0159045]
FlyBase analysis
FlyBase, 2014-, FlyBase Gene Group information.
FlyBase Gene Group information. [FBrf0225556]
Personal communication to FlyBase
Ben-Shahar, 2012.2.9, ppk family update.
ppk family update. [FBrf0217578]
Ashburner et al., 1999.10.12, Adh.
Adh. [FBrf0112153]
Supplementary material
Croset et al., 2010, PLoS Genet. 6(8):
Supporting Information: Table S3. [FBrf0219605]
Warr et al., 2000, Cell 102(2): 145--146
A unified nomenclature system for the Drosophila odorant receptors. [FBrf0130157]