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General Information
Name
PHOSPHATIDYLINOSITOL KINASES
Species
D. melanogaster
Symbol
PI-K
FlyBase ID
FBgg0000633
Date last reviewed
2017-02-01
Number of members
10
Description
Description

Phosphatidylinositol kinases catalyze the phosphorylation of phosphatidylinositol or its phosphorylated derivatives at positions 3, 4 or 5 of the inositol ring. These hydroxyl groups can be phosphorylated individually and in combinations. As a consequence, seven different phosphoinositides can be generated: three monophosphates (PI3P, PI4P and PI5P), three bisphosphates (PI(4,5)P[[2]], PI(3,4)P[[2]] and PI(3,5)P[[2]]) and one trisphosphate PI(3,4,5)P[[3]]. These phosphoinositides can act as signalling molecules to mediate/regulate a range of cellular and physiological processes, including cell polarity, cell migration, autophagy, growth, development, and ageing. (Adapted from FBrf0227909.)

Notes on Group
Source Material
The PHOSPHATIDYLINOSITOL KINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Liu et al., 2018, Balakrishnan et al., 2015, Chakrabarti et al., 2015, and MacDougall et al., 1995 .
Key Gene Ontology (GO) terms
Molecular Function
Cellular Component
Related Gene Groups
Parent group(s)
Members (10)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Phosphatidylinositol 3-kinase 59F
Vps34, PI3K, dPI3K, PI3K_59F, DmVps34
Phosphatidylinositol 3-kinase 68D
PI3K, PI3K_68D, dPI3K, cpk, PI(3)K
Phosphatidylinositol 3-kinase 92E
Dp110, PI3K, p110, dPI3K, PI(3)K
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Phosphatidylinositol 4-kinase II α
PI4KII
Phosphatidylinositol 4-kinase III α
zw2, l(1)zw2, EG:BACR7C10.2, zw-2, PI4K
Phosphatidylinositol 5-phosphate 4-kinase
dPIP4K
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
fab1 kinase
PtdIns(3)P 5-kinase, EG:52C10.5
Phosphatidylinositol 4-phosphate 5-kinase 59B
dPIP5K, PIP5K 59B, PI4P5K
skittles
PIP5K, fam, PIP5-kinase, l(2)05475
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
PI-K
PHOSPHATIDYLINOSITOL KINASES
Phosphatidylinositol phosphate kinases
PI kinases
PIP kinases
Phosphoinositide kinases
Secondary FlyBase ID(s)
References (5)