General Information
Name
WATER CHANNEL PROTEINS
Species
D. melanogaster
Symbol
WCP
FlyBase ID
FBgg0000652
Date last reviewed
2017-02-13
Number of members
8
Description
Description
Water channel proteins (WCPs) are integral membrane proteins with a central pore formed form two highly conserved hydrophobic regions, NPA boxes, which contain the signature Asp-Pro-Ala motif. All WCPs conduct water across the membrane. The aquaglyceroporins also allow the passage of other small molecules. (Adapted from PMID:22542572).
Notes on Group
Source Material
The WATER CHANNEL PROTEINS Gene Group has been compiled by FlyBase curators using the following publication(s): Ishibashi, 2006, Kaufmann et al., 2005, and Finn et al., 2015.
Key Gene Ontology (GO) terms
Molecular Function
Related Gene Groups
Members (8)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
External Data
Synonyms and Secondary IDs
Synonym(s)
WCP
WATER CHANNEL PROTEINS
Aquaporins
Secondary FlyBase ID(s)
References (4)
Research paper
Finn et al., 2015, Nat. Commun. 6: 7814
Insect glycerol transporters evolved by functional co-option and gene replacement. [FBrf0232035]
Kaufmann et al., 2005, Am. J. Physiol., Cell Physiol. 289(2): C397--C407
Developmental expression and biophysical characterization of a Drosophila melanogaster aquaporin. [FBrf0187077]
FlyBase analysis
FlyBase, 2014-, FlyBase Gene Group information.
FlyBase Gene Group information. [FBrf0225556]
Review
Ishibashi, 2006, Biochim. Biophys. Acta 1758(8): 989--993
Aquaporin subfamily with unusual NPA boxes. [FBrf0193444]