FB2025_02 , released April 17, 2025
Gene Group: BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS
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General Information
Name
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS
Species
D. melanogaster
Symbol
BHLH
FlyBase ID
FBgg0000727
Date last reviewed
2017-06-07
Number of members
59
Description
Description
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Notes on Group
Source Material
The BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS Gene Group has been compiled using the following publication(s): Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, and Ledent and Vervoort, 2001 .
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
Members (59)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
BHLH
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS
Basic helix loop helix proteins
Secondary FlyBase ID(s)
References (5)