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General Information
Name
TRANSCRIPTION FACTORS
Species
D. melanogaster
Symbol
TFS
FlyBase ID
FBgg0000745
Date last reviewed
2017-06-01
Number of members
628
Description
Description
Transcription factors are proteins that bind DNA regulatory elements and either activate or repress transcription. They are defined by the presence of one or more sequence-specific DNA binding domains, falling into several families depending on the type of DNA binding domain present. (Adapted from FBrf0226298).
Notes on Group
Source Material
The TRANSCRIPTION FACTORS Gene Group has been compiled by FlyBase curators using the following publication(s): Pflugfelder et al., 2017, Bürglin and Affolter, 2016, Zolotarev et al., 2016, Shaman et al., 2014, Shukla et al., 2014, Hammonds et al., 2013, Krystel and Ayyanathan, 2013, Ly et al., 2013, Naggan Perl et al., 2013, Verma et al., 2013, Fahrbach et al., 2012, Sui et al., 2012, Freeman et al., 2011, Kim et al., 2010, Pfreundt et al., 2010, Zhong and Holland, 2010, Hetru and Hoffmann, 2009, Lin et al., 2009, Bao and Friedrich, 2008, Duncan et al., 2008, Gillis et al., 2008, Li et al., 2007, Sessa and Bianchi, 2007, Simionato et al., 2007, Soustelle and Giangrande, 2007, Yoshioka et al., 2007, Senger et al., 2006, King-Jones and Thummel, 2005, Han et al., 2004, Lee and Frasch, 2004, Srivastava et al., 2004, Hultmark, 2003, Liu et al., 2003, Mazet et al., 2003, Prpic et al., 2003, Reim et al., 2003, Roussigne et al., 2003, Alfonso and Jones, 2002, Bhaskar and Courey, 2002, Chung et al., 2002, Fassler et al., 2002, Siegmund and Lehmann, 2002, Wilsker et al., 2002, Demidenko et al., 2001, Frolov et al., 2001, Ledent and Vervoort, 2001, Maglich et al., 2001, Popovici et al., 2001, Breitling and Gerber, 2000, Hobert and Westphal, 2000, Kawakami et al., 2000, Zhu et al., 2000, Galliot et al., 1999, Paumard-Rigal et al., 1998, Rosinski and Atchley, 1998, Sawado et al., 1998, Stein et al., 1998, Akiyama et al., 1996, Dushay et al., 1996, Gregory et al., 1996, Petersen et al., 1995, Thummel, 1995, Chen et al., 1992, Billin et al., 1991, and Kim and Nirenberg, 1989 .
Key Gene Ontology (GO) terms
Related Gene Groups
Members (628)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
retained
dri, dead ringer, l(2)02535, Dead Ringer/Retain
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Enhancer of split m3, helix-loop-helix
m3, E(spl)m3, HLHm3, E(spl)C m3, E(spl)-m3
Enhancer of split m5, helix-loop-helix
m5, E(spl)m5, HLHm5, HLH-m5, E(spl) region transcript m5
Enhancer of split m7, helix-loop-helix
m7, E(spl)m7, HLHm7, E(spl)-m7, E(spl) region transcript m7
Enhancer of split m8, helix-loop-helix
E(spl)m8, m8, E(spl), Enhancer of split, E(spl)-m8
Enhancer of split mβ, helix-loop-helix
E(spl)mβ, mβ, HLHmβ, HLHmbeta, E(spl)-mβ
Enhancer of split mδ, helix-loop-helix
mδ, E(spl)mδ, HLHmdelta, HLHmδ, E(spl)mdelta
Enhancer of split mγ, helix-loop-helix
mγ, E(spl)mγ, HLHmγ, HLHmgamma, E(spl) region transcript mγ
extra macrochaetae
l(3)05592, ms(3)61CD, gov, extramacrochaete, Ach
germ cell-expressed bHLH-PAS
Germ cell-expressed, germ-cell expressed
knot
col, collier, collier/knot, knotted
Methoprene-tolerant
Rst(1)JH, DmMet, Resistance to Juvenile Hormone
Mnt
dMnt, dMad, Mad, Mad-3E, EG:114E2.2
Sterol regulatory element binding protein
HLH106, dSREBP, SREBF1, l(3)76BDw, Helix loop helix protein 106
taiman
l(2)01351, l(2)k05809, DAIB1, l(2)k05802
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Activating transcription factor-2
ATF2, dATF-2, dATF2
Activating transcription factor 3
A3-3, EG:33C11.1, dATF3
cap-n-collar
Nrf2, CncC, cap and collar, Cap 'n' collar, l(3)03921
cryptocephal
ATF4, l(2)crc, dATF4, ATF-4
Cyclic-AMP response element binding protein A
dCREB-A, CREB, BBF-2, dCREBA, Creb-A
Cyclic-AMP response element binding protein B
dCREB2, CREB, CrebB-17A, dCREB2-b, CREB2
Inverted repeat binding protein 18 kDa
Jun-related antigen
jun, Djun, D-Jun, AP-1, c-Jun
PAR-domain protein 1
Pdp1ε, pdp, Par domain protein 1ε, Pdp1&e;gr, Pdp1e
Repressed by TOR
sisterless A
sis-a, sis a
slow border cells
C/EBP, DmC/EBP, slobo
X box binding protein-1
l(2)k13803, xbp-1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Adult enhancer factor 1
AEF-1
ASCIZ zinc finger protein
dASCIZ
(A+T)-stretch binding protein
brother of odd with entrails limited
bowel, Su(tor)2-1
broad
BR-C, Broad Complex, ecs, rbp, npr1
Bromodomain-containing protein, 140kD
Bub3 interacting GLEBS and Zinc finger domain protein
Dm_2L:87597, lincRNA.S1359
castor
ming, l(3)neo33
cabut
EP2237, dTIEG
combgap
mig, l(2)07659
Chronologically inappropriate morphogenesis
charlatan
l(2)02064
cubitus interruptus
l(4)17, ciD, CID, l(4)13, ci-D
CKII-α subunit interactor-1
Chromatin-linked adaptor for MSL proteins
Centrosomal protein 190kD
Rb188, DMAP190, Cen190, CP-190, Centrosomal Protein 190
CTCF
dCTCF, CCCTC-binding factor
dendritic arbor reduction 1
debra
EP456, BcDNA:LD26519
disco-related
bae, batone
DNA replication-related element factor
DRE-binding factor, dDREF, DNA replication-related element-binding factor, DNA replication-related element binding factor
deformed wings
Zw5, l(1)zw5, zw-5, EG:95B7.6, zeste-white 5
escargot
l(2)35Ce, l(2)br43, dgl, fleabag, Fusion-1
fruitless
satori, sat, BTB-VI
Glucose transporter 4 enhancer factor
stretch, BcDNA:GH25505, BcDNA:GM06804, stretched out
huckebein
gurtelchen, gurt
jing
1.28, l(2)01094, rhumba, l(2)22F3
ken and barbie
Ken & Barbie, ok, okina
Kruppel-like factor 15
Bteb2
klumpfuss
l(3)09036, l(3)10052
Kruppel homolog 1
Kr-h, Pow, Passion of white, l(2)10642
Lobe
Oaz, O/E-associated zinc finger protein, l(2)03563, Dm_2R:42259
Linking immunity and metabolism
lame duck
minc, gfl, myoblasts incompetent, gleeful
longitudinals lacking
eyeful, BTB-IV, bumper-to-bumper, btb, l(2)00642
maternal gene required for meiosis
lincRNA.990
Meiotic central spindle
zinc-finger-motif-protein
Misexpression suppressor of ras 4
EP0386
molting defective
DTS-3, l(3)3DTS
Metastasis associated 1-like
dMTA1-like, MTA-like, dMTA, MTA1, MTA
Metal response element-binding Transcription Factor-1
dMTF-1, metal responsive transcription factor
nervous fingers 1
Nerfin
Neuroectoderm-expressed 2
no ocelli
l(2)35Ba, l(2)br22, nocA, br22, BG:DS04641.1
Optix-binding protein
Obp
ovo
svb, shavenbaby, shaven baby, ovo/svb, ovoD
pebbled
hnt, Hindsight, EP55
pleiohomeotic
l(4)29, YY1, l(4)OC-1, l(4)102EFc, polyhomeotic
pleiohomeotic like
Pho-like
Promyelocytic leukemia zinc finger
PR/SET domain 13
putzig
Z4, Pzg/Z4, p160
rotund
roe, roughened eye, P5.3, tot, tod
spalt major
sal, spalt, l(2)03602
spalt-related
spalt, sal, sal-r
senseless
Ly, Sensless, sen, sense
sequoia
vr5, l(2)49Fc, l(2)vr5
schnurri
quo, l(2)04738, EP2359
snail
Sco, l(2)br28, l(2)35Db, l(2)br29, br29
sister of odd and bowl
Sp1-like factor for pairing sensitive-silencing
Serendipity δ
sryδ, serendipity delta, EH8, sry δ, sry
suppressor of Hairy wing
suHw
teflon
l(2)k15914
Trithorax-like
GAF, GAGA, GAGA factor, Nc70F, GAGA-factor
tramtrack
Ttk69, Tramtrack69, oversensitive, Ttk88, FTZ-F2
u-shaped
FOG, dFOG
wings down
pqp, pourquoi-pas, sry-h1
weckle
l(2)35Ea, BG:DS09217.5
worniu
l(2)br35, l(2)35Da, br35, BG:DS03023.1
ZAD and Architectural Function 1
zinc finger protein 30C
l(2)k02506, C282
Zn finger homeodomain 1
zfh-1, zinc finger homeodomain 1, Zinc-finger homeodomain protein 1, l(3)00865
Zn finger homeodomain 2
zfh-2, zinc finger homeodomain 2
zelda
vfl, vielfaltig, EP1344
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
defective proventriculus
l(2)01738
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
DP transcription factor
dDP, DP1, l(2)vr10
E2F transcription factor 1
E2F, dE2F1, dE2F, E(var)3-93E, drosE2F1
E2F transcription factor 2
dE2F2, E2f
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
anterior open
yan, pokkuri, pok, DROYANETSB, aop/yan
Ecdysone-induced protein 74EF
E74, E74A, E74B, ECIP, Eip74
Ets at 97D
D-elg, Delg, elg
pointed
PntP1, PntP2, D-ets-2, pointed-P1, pointedP2
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Checkpoint suppressor 1-like
anon-EST:Posey7
Circadianly Regulated Gene
crg1
fork head
Secretion enhancer-binding protein 2, Sebp2
forkhead box, sub-group O
dFOXO, Forkhead box O, forkhead box sub-group O, FKHR, forkhead transcription factor
Forkhead box P
fd85E, forkhead domain 85E
jumeau
Dom, jumeaux, Domina, l(3)06439, l(3)06142
sloppy paired 1
slp, sloppy-paired, sloppy paired, slp-1, FD6
sloppy paired 2
slp, sloppy-paired, sloppy paired, FD7, FoxG
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
grain
GATAc, gra, dGATAc, Gata-c, l(3)84Fa
serpent
dGATAb, GATAb, ABF, GATA, l(3)01549
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
glial cells missing
glide/gcm, glide, glial cell missing, glial cell deficient
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Brahma associated protein 111kD
dalao, BAF57
capicua
fettucine, fet, E(Dl)D49
Dichaete
fish, fish-hook, DM33, DM36, DM10
Dorsal switch protein 1
Hmg14B
High mobility group protein 2
BEST:LD07122
High mobility group protein D
HMG-D, HMG D, HMG1
HMG protein Z
HMG-Z
Lost PHDs of trr
cmi, cara mitad
pangolin
dTCF, TCF, l(4)13, LEF-1, T cell factor
polybromo
PB, bap180, baf180
Structure specific recognition protein
SSRP1, dSSRP1
mitochondrial transcription factor A
mtTFA, d-TFAM
testis-enriched HMG-box-containing protein 1
testis-enriched HMG-box-containing protein 2
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Adh transcription factor 1
Adf-1, nal, nalyot, l(2)01349, Adf 1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Mothers against dpp
pMad, Mothers Against Decapentaplegic, Mother against decapentaplegic, dMad, Smad
Medea
l(3)SG70, dSmad4, l(3)11m-254, smad4
Nuclear factor I
Smad on X
dSmad2, Smad2, Smad, l(1)G0348, Sad
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
blistered
DSRF, SRF, pruned, D-SRF, serum response factor
Myocyte enhancer factor 2
Dmef2, D-mef2, Myocyte enhancing factor 2, Mef-2, Dmef
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Distal-less
Ba, l(2)01092, Brista, Distall-less
Drop
msh, muscle segment homeobox, muscle specific homeobox, msh1, msh-1
ventral nervous system defective
NK-2, vnd/NK-2, NK2, EC6, EG:118B3.1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
dorsal
NFκB, NF-κB, GSd447
Relish
NF-κB, ird4, NFκB, l(3)neo36, Rel1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
NFAT nuclear factor
EP1335, Misexpression Suppressor of Ras 1, MESR1, Rel domain protein
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Ecdysone receptor
EcR-B1, EcRB1, DmEcR, EcR-A, ecdysteroid receptor
Ecdysone-induced protein 75B
E75, E75A, E75B, E75C, l(3)neo25
Ecdysone-induced protein 78C
E78, E78B, E78A, NR1E1, Eip78
ftz transcription factor 1
βFTZ-F1, β FTZ-F1, ftz-f1α, ftzf1, αftz-f1
Hepatocyte nuclear factor 4
dHNF4, dHNF-4, Hnf-4, HNF4α, NR2A4
Hormone receptor 3
DHR3, Hr46, Hormone receptor-like in 46, NR1F4, Complementation group D
Hormone receptor 4
DHR4, EP1232, EG:BACH61I5.1, EG:133E12.2, NR6A2
Hormone receptor-like in 38
DHR38, 38E.3, 38E.7, NR4A4
Hormone receptor-like in 39
DHR39, ftz-F1β, NR5B1, fs(2)04443, fs(2)neo8
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
bunched
shs, l(2)00255, TSC-22, Dm_2L:60722
Calmodulin-binding transcription activator
croaker, dCAMTA, cro, Calmodulin-binding transcription factor, DmCAMTA
D1 chromosomal protein
dachshund
dachsund, dacshund, l(2)36Ae, BG:DS02780.3, Dach
Deformed epidermal autoregulatory factor-1
DEAF-1
Enhancer of bithorax
NURF301, NURF, p301, Nurf-215, dNURF
elbow B
el, elbow, BG:DS06238.3
erect wing
EC3, EG:BACR37P7.7, l(1)1Ag, l(1)EC3
female sterile (1) homeotic
fsh, Fs(1)h-L, fs(1)M16, fs(1)1456, l(1)7Da
fussel
dCORL, CORL
grainy head
NTF-1, Elf-1, Gh, Elf1, l(2)06850
Heat shock factor
dHSF, l(2)03091, heat-shock transcription factor, HSF1, DmHSF
lilliputian
l(2)00632, Su(Raf)2A, SY2-1, l(2)23Cc, SS2-1
Myocardin-related transcription factor
DMRTF, mal-d, mal
Negative Cofactor 2α
Drap1
Negative Cofactor 2β
Dr1, BG:DS00929.3, NC2 beta
p53
Dmp53, dp53
Rfx
dRFX, Regulatory factor X
relative of woc
Sno oncogene
dSno, SnoN, dSki, l(2)SH1402
Signal-transducer and activator of transcription protein at 92E
STAT, marelle, mrl, D-STAT, Dstat
shuttle craft
l(2)35Cb, l(2)br33, br33, BG:DS04929.4
Suppressor of Hairless
l(2)br7, SuH, Supressor of Hairless, CSL, l(2)35Bh
Thymine DNA glycosylase
Thd1, G/T-mismatch-specific-thymine-DNA-glycosylase, MUG
Transcription factor AP-2
dAP-2, AP-2, AP-2α, l(3)1215
without children
zeste
EG:BACH59J11.3
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
shaven
D-Pax2, spa, sparkling, Pax2, dPax2
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
eyeless
Pax6, l(4)33, Pax-6, OK107, eye
gooseberry-neuro
gsb-p, gsb, gsbn, BSH4, gsb-neuro
twin of eyg
twin of eyegone
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Goosecoid
D-gsc, 60Mun2, l(2)05341, Muenster 72
ocelliless
otd, orthodenticle, Otx, ort, orthodentical
orthopedia
W26, bk24
reversed polarity
RK2, reverse polarity
Retinal Homeobox
DRx, E97, bk50, PPH17
Visual system homeobox 1
dChx1, Chx1, Vsx, lincRNA.S8688, dVsx1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
bric a brac 1
bab, bric-a-brac, bric a brac, bab-I, bric a brac I
bric a brac 2
bab, bab-II, bric-a-brac, bric a brac, BTB-II
distal antenna-related
hernandez
Ecdysone-induced protein 93F
E93, psg11, l(3)ry93, lincRNA.833, l(3)93
jim lovell
Tkr, dTKR, BTB-III, 91Y, Tyrosine kinase-related protein
pipsqueak
eyeful, BTB-V, rumpf, pip, rum
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
abnormal chemosensory jump 6
I-POU
nubbin
Pdm1, pdm-1, Pdm, POU domain protein 1, dPOU-19
POU domain protein 2
pdm-2, pdm, miti, dPOU28, dPOU-28
ventral veins lacking
drifter, dfr, Cf1a, ventral veinless, Drf
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
prospero
Voila, DROPROSA, pro, a la voile et a la vapeur, Prosp
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
apontic
tdf, tracheae defective, l(2)09049, l(2)06369, l(2)59Ea
Myb oncogene-like
Dm-Myb, Dm myb, D-myb, dMyb, c-Myb
PSEA-binding protein 95kD
DmSNAP190, DmPBP
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
araucan
iro, iroquois, Iro-C, IroC
extradenticle
Dpbx, lincRNA.S9404
homothorax
dorsotonals, dtl, P53, anon-EST:Liang-2.13
mirror
Iro-C, iro, iroquois, mrr, Sail
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
bifid
omb, optomotor-blind, optomotor blind, l(1)omb, Qd
H15
nmr, nmr1, neuromancer, neuromancer1, neuromancer 1
midline
nmr2, neuromancer2, extra, los, neuromancer 2
optomotor-blind-related-gene-1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
scalloped
l(1)G0483, l(1)G0309, sp, l(1)G0262, l(1)G0239
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Zn finger homeodomain 1
zfh-1, zinc finger homeodomain 1, Zinc-finger homeodomain protein 1, l(3)00865
Zn finger homeodomain 2
zfh-2, zinc finger homeodomain 2
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TFS
TRANSCRIPTION FACTORS
Secondary FlyBase ID(s)
References (66)