The SANT-MYB domain transcription regulators are essentially part of chromatin remodelling complexes and co-repressors. The SANT domain shows similarity with DNA-binding helix-turn-helix of Myb domain, and are involved in protein-protein interactions in the chromatin complexes. (Adapted from PMID:15040448).
The SANT domain name refers to four of the first members identified with this motif: Swi3, Ada2, N-CoR, TFIIIB (PMID:15040448).