Runt-domain (RD) transcription factors are sequence-specific DNA binding proteins that regulate transcription. These proteins are characterized by a Runt domain of 128 amino acids that mediates DNA binding and heterodimerization with a non-DNA binding β-subunit to form the Core Binding Factor transcription factor complex. (Adapted from FBrf0206845 and FBrf0138356).

The RUNT DOMAIN TRANSCRIPTION FACTORS heterodimerize with non-DNA binding β-subunits Bro or Bgb, which are CORE BINDING FACTOR BETA members, to form the Core Binding Factor transcription factor complex (FBrf0138356).