FB2022_02, released March 29, 2022

Gene Group - Pathway: Negative Regulators of Wnt-TCF Signaling Pathway

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General Information
Name
Negative Regulators of Wnt-TCF Signaling Pathway
Species
D. melanogaster
Symbol
WNT-TCFN
FlyBase ID
FBgg0000891
Date last reviewed
2019-11-14
Number of members
40
Description
Description
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
Notes and selected reviews

Negative regulators of the canonical Wnt signaling pathway include Destruction Complex components which, in the absence of Wnt signaling, constitutively suppress the pathway by promoting cytoplasmic β-catenin (arm) degradation.

Biological Process Gene Ontology (GO) term(s)
negative regulation of canonical Wnt signaling pathway
Related Gene Groups
Parent group(s)
Wnt-TCF Signaling Pathway
Protein Complex group(s)
BETA CATENIN DESTRUCTION COMPLEX
SCF-SLMB UBIQUITIN LIGASE COMPLEX
Physical Interaction Network
Members (40)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
Negative Regulators of Wnt-TCF Signaling Pathway
Negative Regulators of Canonical Wnt Signaling Pathway
WNT-TCFN
WNT-CANN
Secondary FlyBase ID(s)
References (70)