Gene Group - Pathway: Negative Regulators of Wnt-TCF Signaling Pathway

General Information

Name

Negative Regulators of Wnt-TCF Signaling Pathway

Species

D. melanogaster

Symbol

WNT-TCFN

FlyBase ID

FBgg0000891

Date last reviewed

2018-04-11

Number of members

38

Description

Description

Negative regulators of canonical Wnt signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).

Notes and selected reviews

Negative regulators of the canonical Wnt signaling pathway include Destruction Complex components which, in the absence of Wnt signaling, constitutively suppress the pathway by promoting cytoplasmic β-catenin (arm) degradation.

Biological Process Gene Ontology (GO) term(s)

negative regulation of canonical Wnt signaling pathway

Related Gene Groups

Parent group(s)

Wnt-TCF Signaling Pathway

Protein Complex group(s)

BETA CATENIN DESTRUCTION COMPLEX

SCF-SLMB UBIQUITIN LIGASE COMPLEX

Physical Interaction Network

Members (38)

For all members:

Gene Symbol

Gene Name

Gene Group Membership

GO Molecular Function (Experimental)

# Refs

anterior open

ETS DOMAIN TRANSCRIPTION FACTORS

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

protein domain specific binding

RNA polymerase II regulatory region DNA binding

RNA polymerase II proximal promoter sequence-specific DNA binding

APC-like

BETA CATENIN DESTRUCTION COMPLEX

beta-catenin binding

Adenomatous polyposis coli 2

BETA CATENIN DESTRUCTION COMPLEX

molecular adaptor activity

beta-catenin binding

Axin

BETA CATENIN DESTRUCTION COMPLEX

signaling receptor binding

molecular adaptor activity

beta-catenin binding

protein kinase binding

Band4.1 inhibitor LRP interactor

Cell division cycle 16

ANAPHASE-PROMOTING COMPLEX

ubiquitin protein ligase activity

Casein kinase Iα

BETA CATENIN DESTRUCTION COMPLEX

protein serine/threonine kinase activity

Corepressor of Pangolin

MADF-BESS DOMAIN TRANSCRIPTION REGULATORS

transcription factor binding

transcription corepressor activity

Carrier of Wingless

Wnt-protein binding

C-terminal Binding Protein

TORC REMODELING COMPLEX

OTHER CH-OH OXIDOREDUCTASES, NAD OR NADP AS ACCEPTOR

protein homodimerization activity

repressing transcription factor binding

transcription corepressor activity

transcription coactivator activity

transcription factor binding

Cullin 1

SCF-SLMB UBIQUITIN LIGASE COMPLEX

ubiquitin protein ligase binding

groucho

transcription factor binding

transcription corepressor activity

repressing transcription factor binding

CRD domain binding

HMG box domain binding

licorne

STE7 KINASES (MAPK KINASES)

mitogen-activated protein kinase kinase kinase binding

protein kinase activity

MAP kinase kinase activity

mir-8 stem loop

mir-310 stem loop

mir-311 stem loop

mir-312 stem loop

mir-313 stem loop

Matrix metalloproteinase 2

metalloendopeptidase activity

endopeptidase activity

nejire

TRITHORAX ACETYLATION COMPLEX 1

HISTONE ACETYLTRANSFERASES

histone acetyltransferase activity

histone acetyltransferase activity (H3-K27 specific)

transcription coactivator activity

transcription factor binding

histone methyltransferase binding

histone acetyltransferase activity (H3-K18 specific)

naked cuticle

zinc ion binding

PDZ domain binding

nemo

ATYPICAL MITOGEN ACTIVATED PROTEIN KINASES

protein serine/threonine kinase activity

protein kinase activity

Notum

phospholipase activity

deacetylase activity

off-track

RECEPTOR TYROSINE KINASES

cell adhesion molecule binding

Wnt-protein binding

protein homodimerization activity

transmembrane receptor protein tyrosine kinase activity

protein heterodimerization activity

pavarotti

pebble

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS

Rho GTPase binding

semaphorin receptor binding

Rho guanyl-nucleotide exchange factor activity

Rac guanyl-nucleotide exchange factor activity

phosphatidylinositol phosphate binding

phyllopod

protein binding, bridging involved in substrate recognition for ubiquitination

Ran binding protein 3

Rho1

GTPase activity

Regulator of cullins 1a

ROC UBIQUITIN LIGASES

SCF-SLMB UBIQUITIN LIGASE COMPLEX

NEDD8 TRANSFERASES

cullin family protein binding

ubiquitin protein ligase activity

shaggy

GLYCOGEN SYNTHASE 3-LIKE KINASES

BETA CATENIN DESTRUCTION COMPLEX

protein serine/threonine kinase activity

Sin3A

protein heterodimerization activity

chromatin binding

SKP1-related A

SKP1 GENE FAMILY

SCF-SLMB UBIQUITIN LIGASE COMPLEX

supernumerary limbs

F BOX AND WD DOMAIN PROTEINS

SCF-SLMB UBIQUITIN LIGASE COMPLEX

phosphoprotein binding

ubiquitin-protein transferase activity

SoxNeuro

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS

DNA-binding transcription factor activity, RNA polymerase II-specific

chromatin DNA binding

Sulfated

N-acetylglucosamine-6-sulfatase activity

tumbleweed

RHO GTPASE ACTIVATING PROTEINS

External Data

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

Negative Regulators of Wnt-TCF Signaling Pathway

Negative Regulators of Canonical Wnt Signaling Pathway

WNT-TCFN

WNT-CANN

Secondary FlyBase ID(s)

References (64)

Report Sections