The Tsc1-Tsc2 complex is a heterodimeric GTPase Activating Protein (GAP) complex that negatively regulates mTOR (TORC1 complex) signaling. The Tsc1-Tsc2 complex stimulates the small GTPase, Rheb, to hydrolyze bound GTP to GDP. GTP-bound Rheb activates TORC1. (Adapted from FBrf0214848 and FBrf0136941).
Notes on Group
Source Material
The
TSC1-TSC2 COMPLEX
Gene Group has been compiled using the following publication(s):
Gao and Pan, 2001
.
