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General Information
Name
Torso Signaling Pathway Core Components
Species
D. melanogaster
Symbol
TORS-C
FlyBase ID
FBgg0000937
Date last reviewed
2018-06-19
Number of members
22
Description
Description

The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)

Notes and selected reviews

The ligand for Torso receptor signaling in terminal determination is thought to be trk. tsl is required for torso signaling, but its role is unclear. It has been proposed to act as an anchor for trk or control localized cleavage of trk (FBrf0224259). However, in vitro, tsl has been shown to act as a torso agonist alone and with trk (FBrf0234821).

The eggshell proteins encoded by fs(1)N, fs(1)M3 and clos are required for terminal signaling, possibly by anchoring or stabilizing of tsl at the vitelline membrane (FBrf0235104).

tor also acts as a receptor for the Prothoracicotropic hormone, Ptth, regulating ecdysone production during metamorphosis (FBrf0209466).

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Members (22)
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Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TORS-C
Torso Signaling Pathway Core Components
Secondary FlyBase ID(s)
References (45)