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General Information
Name
FK506-BINDING PROTEINS
Species
D. melanogaster
Symbol
FKBP
FlyBase ID
FBgg0000947
Date last reviewed
2019-11-08
Number of members
8
Description
Description

FK506-binding proteins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, FK506 or rapamycin, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. FK506-binding proteins are characterized by the presence of a 'FKBP-type peptidyl-prolyl cis-trans isomerase domain' (IPR001179). (Adapted from PMID:25986569.)

Notes on Group

Bdbt (FBgn0038857) has the InterPro family signature "Peptidyl-prolyl cis-trans isomerase, FKBP-type (IPR023566)" but lacks the InterPro domain "FKBP-type peptidyl-prolyl cis-trans isomerase domain (IPR001179)". Further, Bdbt is not included in the list of FKBP family protein in FBrf0238473, and so is excluded from the FKBP Gene Group.

Source Material
The FK506-BINDING PROTEINS Gene Group has been compiled by FlyBase curators using the following publication(s): Ghartey-Kwansah et al., 2018 .
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
Members (8)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
FK506-binding protein 12kD
FK506-bp2, FK506-binding protein 2
FK506-binding protein 14
Fkbp13, l(2)00734, BcDNA.GM07659
FK506-binding protein 39kD
FK506-bp1, FK506-binding protein 1
FK506-binding protein 59kD
dFKBP59, l(2)k00424, FKBP59-bp1
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
FKBP
FK506-BINDING PROTEINS
Secondary FlyBase ID(s)
References (3)