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General Information
Name
Negative Regulators of Epidermal Growth Factor Receptor Signaling Pathway
Species
D. melanogaster
Symbol
EGFR-N
FlyBase ID
FBgg0000950
Date last reviewed
2018-07-11
Number of members
27
Description
Description
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Notes and selected reviews
rho-5 has been included as a negative regulator of the EGFR pathway. However, it acts upstream of the pathway, down-regulating the production of secreted receptor ligand (FBrf0213387).
Related Gene Groups
Members (27)
For all members:
Gene Symbol
Gene Name
Gene Group Membership
GO Molecular Function (Experimental)
# Refs
ADAM metallopeptidase with thrombospondin type 1 motif B
Fasciclin 2
mir-8 stem loop
Mitogen-activated protein kinase phosphatase 3
Protein tyrosine phosphatase 4E
Ras GTPase activating protein 1
small wing
Suppressor of cytokine signaling at 36E
sprouty
tay bridge
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
EGFR-N
Negative Regulators of Epidermal Growth Factor Receptor Signaling Pathway
Secondary FlyBase ID(s)
References (44)