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General Information
Name
Hedgehog Signaling Pathway Core Components
Species
D. melanogaster
Symbol
HH-SMOC
FlyBase ID
FBgg0000979
Date last reviewed
2018-10-31
Number of members
7
Description
Description

The hedgehog signaling pathway is initiated by hedgehog (hh) ligand binding to the extracellular domain of patched receptor (ptc), leading to the derepression of smoothened (smo) activity. Activation of the atypical GPCR smo results in the accumulation of the transcriptional activator form of cubitus interruptus (ci) and the derepression/activation of hh target genes. In the absence of hh, smo is repressed by ptc and ci is processed to a truncated repressor form. (Adapted from FBrf0220683 and FBrf0231236).

Notes and selected reviews
Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Physical Interaction Network
Members (7)
For all members:
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
HH-SMOC
Hedgehog Signaling Pathway Core Components
Secondary FlyBase ID(s)
References (69)