Open Close
General Information
Name
Positive Regulators of Notch Signaling Pathway
Species
D. melanogaster
Symbol
NTCH-P
FlyBase ID
FBgg0001069
Date last reviewed
2019-01-23
Number of members
35
Description
Description

The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).

Notes and selected reviews
Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Physical Interaction Network
Members (35)
For all members:
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
NTCH-P
Positive Regulators of Notch Signaling Pathway
Secondary FlyBase ID(s)
References (64)