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General Information
Name
PROTEIN O-MANNOSYLTRANSFERASES
Species
D. melanogaster
Symbol
POMANT
FlyBase ID
FBgg0001328
Date last reviewed
2020-02-10
Number of members
7
Description
Description

Protein O-mannosyltransferases transfer a mannose residue from dolichyl phosphate D-mannose to the oxygen atom of the hydroxyl group of selected serine/threonine residues. In contrast to yeast, O-Man glycosylation in metazoans is found only on select proteins. The evolutionary conserved POMT1/POMT2 enzymes target the dystroglycan protein, while the TMTC proteins selectively serve cadherins and protocadherins. (Adapted from PMID:28973932 and FBrf0244700.)

These enzymes are localized in the endoplasmic reticulum.

Notes on Group
Source Material
The PROTEIN O-MANNOSYLTRANSFERASES Gene Group has been compiled by FlyBase curators using the following publication(s): Li et al., 2020, Walski et al., 2017, and Yamamoto-Hino et al., 2015 .
Key Gene Ontology (GO) terms
Related Gene Groups
Parent group(s)
Members (7)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Transmembrane O-mannosyltransferase targeting cadherins 3
twisted
POMT2, EG:34F3.7, dPOMT2, Protein O-mannosyltransferase 2
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
POMANT
PROTEIN O-MANNOSYLTRANSFERASES
Secondary FlyBase ID(s)
References (5)