FB2025_01 , released February 20, 2025
Gene Group: WIRINS
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General Information
Name
WIRINS
Species
D. melanogaster
Symbol
WRN
FlyBase ID
FBgg0001381
Date last reviewed
2020-04-22
Number of members
37
Description
Description
Wirins are members of a widely distributed family of two- and three-Ig domain molecules that mediate axonal guidance, synapse targeting, and other neuronal wiring-related functions. Beginning from a single ancestral Wirin gene in the last common ancestor of Bilateria, numerous gene duplications produced the heterophilic Dprs and DIPs in protostomes, along with two other subfamilies that diversified independently across protostome phyla. In deuterostomes, the ancestral Wirin evolved into the IgLON subfamily of neuronal receptors.(Adapted from FBrf0245249.)
Notes on Group
Source Material
The WIRINS Gene Group has been compiled using the following publication(s): Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, and Nakamura et al., 2002 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
neuron projection guidance
synapse organization
Cellular Component
plasma membrane
Related Gene Groups
Component group(s)
DEFECTIVE PROBOSCIS EXTENSION RESPONSE
DPR-INTERACTING PROTEINS
KLINGON SUBFAMILY OF WIRINS
LACHESIN SUBFAMILY OF WIRINS
Members (37)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
DEFECTIVE PROBOSCIS EXTENSION RESPONSE
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
dpr1
defective proboscis extension response 1
dpr, defective proboscis extension response
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr2
defective proboscis extension response 2
BP1042
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr3
defective proboscis extension response 3
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr4
defective proboscis extension response 4
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr5
defective proboscis extension response 5
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr6
defective proboscis extension response 6
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr7
defective proboscis extension response 7
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr8
defective proboscis extension response 8
CT16867
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr9
defective proboscis extension response 9
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr10
defective proboscis extension response 10
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr11
defective proboscis extension response 11
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr12
defective proboscis extension response 12
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Nakamura et al., 2002)
dpr13
defective proboscis extension response 13
Dm_2R:58906
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr14
defective proboscis extension response 14
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr15
defective proboscis extension response 15
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr16
defective proboscis extension response 16
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr17
defective proboscis extension response 17
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr18
defective proboscis extension response 18
CT34788
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr19
defective proboscis extension response 19
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr20
defective proboscis extension response 20
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013, Vogel et al., 2003, Nakamura et al., 2002)
dpr21
defective proboscis extension response 21
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015)
DPR-INTERACTING PROTEINS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
DIP-α
Dpr-interacting protein α
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013)
DIP-β
Dpr-interacting protein β
BP1062
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013)
DIP-δ
Dpr-interacting protein δ
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013)
DIP-ε
Dpr-interacting protein ε
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013)
DIP-η
Dpr-interacting protein η
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013)
DIP-γ
Dpr-interacting protein γ
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013)
DIP-ι
Dpr-interacting protein ι
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013)
DIP-κ
Dpr-interacting protein κ
BG:DS08249.1
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Ozkan et al., 2013)
DIP-λ
Dpr-interacting protein λ
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Ozkan et al., 2013)
DIP-θ
Dpr-interacting protein θ
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013)
DIP-ζ
Dpr-interacting protein ζ
(Sergeeva et al., 2020, Cheng et al., 2019, Cosmanescu et al., 2018, Carrillo et al., 2015, Tan et al., 2015, Ozkan et al., 2013)
KLINGON SUBFAMILY OF WIRINS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG7166
(Cheng et al., 2019)
CG34353
(Cheng et al., 2019)
klg
klingon
l(3)rN712
(Cheng et al., 2019)
wrapper
wrapper
(Cheng et al., 2019)
LACHESIN SUBFAMILY OF WIRINS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Lac
Lachesin
l(2)k11012, bulb
(Cheng et al., 2019)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
WRN
WIRINS
Secondary FlyBase ID(s)
References (9)