Gene Group: MITOCHONDRIAL COMPLEX I

General Information

Name

MITOCHONDRIAL COMPLEX I - ACCESSORY SUBUNITS

Species

D. melanogaster

Symbol

MCI-A

FlyBase ID

FBgg0001387

Date last reviewed

2024-09-16

Number of members

Description

Mitochondrial Complex I is the first and largest holoenzyme of the mitochondrial electron transport chain. It oxidizes NADH from the tricarboxylic acid cycle and β oxidation of fatty acids, reduces ubiquinone and transports protons across the inner membrane, contributing to the proton-motive force. It is also involved in the cellular production of reactive oxygen species. 'Accessory' or 'supernumerary' subunits are all encoded by nuclear DNA and are not directly involved in catalysis. (Adapted from PMID:23527692 and FBrf0244962.)

Notes on Group

The division between 'CORE' and 'ACCESSORY' Complex I subunits in FlyBase follows that given in FBrf0244962.

Readily identifiable orthologs of mammalian NDUFA3 and NDUFC1 are not found in Drosophila (FBrf0244962). However, a subunit matching mammalian NDUFA3 was detected by mass spectrometry in the purified D. melanogaster complex I (FBrf0255922).

The ND-B8 (NDUFA2) protein, which is present as a supernumerary subunit of mammalian complex I, is absent from purified Drosophila complex I. Moreover, ND-B8 expression is restricted principally to the male germline, suggesting the protein is unlikely to be a constitutive component of complex I in somatic tissues. (FBrf0255922)

These nuclear genes encoding accessory subunits of Complex I exist as paralogs in D. melanogaster: ND-B14.5A and ND-B14.5AL; ND-AGGG and CG40472. In most cases, one paralog has widespread expression whereas the other is restricted to the testis. In addition, CG11815 and CG12464 have the same InterPro domain (IPR026193) as CG11752 (a NDUFV3 ortholog, FBrf0244962), but no there is no other orthology/literature evidence suggesting they are subunits of Complex I - CG11815 and CG12464 are therefore not included in this group.

Source Material

The MITOCHONDRIAL COMPLEX I - ACCESSORY SUBUNITS Gene Group has been compiled using the following publication(s): Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, and Tripoli et al., 2005 .

Key Gene Ontology (GO) terms

Molecular Function

Biological Process

mitochondrial electron transport, NADH to ubiquinone

Cellular Component

respiratory chain complex I

mitochondrial inner membrane

Related Gene Groups

Parent group(s)

MITOCHONDRIAL COMPLEX I SUBUNITS

Members (31)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG40472

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017)

ND-13A

NADH dehydrogenase (ubiquinone) 13 kDa A subunit

dNDUFS6

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-13B

NADH dehydrogenase (ubiquinone) 13 kDa B subunit

dNDUFA5, NDUFA5

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-15

NADH dehydrogenase (ubiquinone) 15 kDa subunit

dNDUFS5, NDUFS5

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-18

NADH dehydrogenase (ubiquinone) 18 kDa subunit

dNDUFS4, NDUFS4

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-19

NADH dehydrogenase (ubiquinone) 19 kDa subunit

dNDUFA8, NDUFA8

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-39

NADH dehydrogenase (ubiquinone) 39 kDa subunit

dNDUFA9, NDUFA9

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-42

NADH dehydrogenase (ubiquinone) 42 kDa subunit

ND42, NADH:ubiquinone reductase 42kD subunit precursor, NdufA10, dNDUFA10

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-ACP

NADH dehydrogenase (ubiquinone) acyl carrier protein

mtacp1, mtACP, NADH-ubiquinone oxidoreductase acyl-carrier subunit, mitochondrial acyl carrier protein 1, dNDUFAB1

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-AGGG

NADH dehydrogenase (ubiquinone) AGGG subunit

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Tripoli et al., 2005)

ND-ASHI

NADH dehydrogenase (ubiquinone) ASHI subunit

dNDUFB8, NDUFB8

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B8

NADH dehydrogenase (ubiquinone) B8 subunit

(Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B12

NADH dehydrogenase (ubiquinone) B12 subunit

dNDUFB3, NDUFB3

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B14

NADH dehydrogenase (ubiquinone) B14 subunit

dNDUFA6, NDUFA6

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B14.5A

NADH dehydrogenase (ubiquinone) B14.5 A subunit

EG:152A3.7, dNDUFA7, anon-2Db, NDUFA7

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B14.5AL

NADH dehydrogenase (ubiquinone) B14.5 A subunit-like

(Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Tripoli et al., 2005)

ND-B14.5B

NADH dehydrogenase (ubiquinone) B14.5 B subunit

dNDUFC2

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B14.7

NADH dehydrogenase (ubiquinone) B14.7 subunit

dNDUFA11, NDUFA11

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007)

ND-B15

NADH dehydrogenase (ubiquinone) B15 subunit

dNDUFB4

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B16.6

NADH dehydrogenase (ubiquinone) B16.6 subunit

dNDUFA13, NDUFA13

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B17

NADH dehydrogenase (ubiquinone) B17 subunit

l(2)35Di, BG:DS09217.1, dNDUFB6, lethal (2) 35Di, NDUFB6

(Agip et al., 2023, Rhooms et al., 2020, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B17.2

NADH dehydrogenase (ubiquinone) B17.2 subunit

dNDUFA12, NDUFA12

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B18

NADH dehydrogenase (ubiquinone) B18 subunit

dNDUFB7

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-B22

NADH dehydrogenase (ubiquinone) B22 subunit

dNDUFB9

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-MNLL

NADH dehydrogenase (ubiquinone) MNLL subunit

NDUFB1, dNDUFB1

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-MWFE

NADH dehydrogenase (ubiquinone) MWFE subunit

dNDUFA1

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007)

ND-PDSW

NADH dehydrogenase (ubiquinone) PDSW subunit

Pdsw, dNDUFB10, l(2)k10101

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

ND-SGDH

NADH dehydrogenase (ubiquinone) SGDH subunit

l(3)neo18, dNDUFB5, lethal (3) neo18, NDUFB5

(Agip et al., 2023, Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005)

NdufA3

NADH:ubiquinone oxidoreductase subunit A3

(Agip et al., 2023)

NdufV3

NADH:ubiquinone oxidoreductase subunit V3

dNDUFV3, BcDNA:RH44935

(Agip et al., 2023, Rhooms et al., 2020)

NP15.6

dNDUFB11

(Agip et al., 2023, Rhooms et al., 2020)

External Data

Equivalent Group(s)