FB2025_01 , released February 20, 2025
Gene Group: A1 ASPARTIC ENDOPEPTIDASES
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General Information
Name
A1 ASPARTIC ENDOPEPTIDASES
Species
D. melanogaster
Symbol
A1P
FlyBase ID
FBgg0001403
Date last reviewed
2020-06-08
Number of members
13
Description
Description
A1 aspartic endopeptidases belong to MEROPS family A1, most of which are most active at acidic pH.. They catalyse the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
Notes on Group
Source Material
The A1 ASPARTIC ENDOPEPTIDASES Gene Group has been compiled using the following publication(s): Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
aspartic-type endopeptidase activity
Biological Process
proteolysis
Cellular Component
Enzymatic activity
Enzyme name (EC)
3.4.23.-
Related Gene Groups
Parent group(s)
ASPARTIC PEPTIDASES
Members (13)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Bace
beta-site APP-cleaving enzyme
dBACE
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
cathD
cathepsin D
CTSD
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG5860
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG5863
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG6508
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG10104
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG17134
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG17283
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG31661
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG31926
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG31928
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG33128
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
Pgcl
Pepsinogen C-like
T2, pcl, EG:EG0001.1, pepsinogen-like, scβ
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Family A1](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=A1)

Synonyms and Secondary IDs
Synonym(s)
A1 ASPARTIC ENDOPEPTIDASES
A1
A1P
Secondary FlyBase ID(s)
References (3)