FB2025_01 , released February 20, 2025
Gene Group: A22 ASPARTIC ENDOPEPTIDASES
Open Close
General Information
Name
A22 ASPARTIC ENDOPEPTIDASES
Species
D. melanogaster
Symbol
A22P
FlyBase ID
FBgg0001404
Date last reviewed
2020-06-08
Number of members
3
Description
Description
A22 aspartic endopeptidases belong to MEROPS family A22, which are membrane-inserted endopeptidases. They catalyse the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. The family includes presenilins and signal peptide peptidases. (Adapted from PMID:12966028.)
Notes on Group
Source Material
The A22 ASPARTIC ENDOPEPTIDASES Gene Group has been compiled using the following publication(s): Casso et al., 2012, Narayanan et al., 2007, Ponting et al., 2002, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
aspartic endopeptidase activity, intramembrane cleaving
Biological Process
membrane protein proteolysis
Cellular Component
membrane
Related Gene Groups
Parent group(s)
ASPARTIC PEPTIDASES
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Psn
Presenilin
PS, γ-secretase, dPsn, Dps, dPresenilin
(FlyBase, 2017-, Ponting et al., 2002, Rawlings and Barrett, 1996-)
Spp
Signal peptide peptidase
shanti, Signal peptide protease
(FlyBase, 2017-, Casso et al., 2012, Narayanan et al., 2007, Ponting et al., 2002, Rawlings and Barrett, 1996-)
SppL
Signal peptide peptidase-like
(FlyBase, 2017-, Casso et al., 2012, Narayanan et al., 2007, Ponting et al., 2002, Rawlings and Barrett, 1996-)
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Family A22](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=A22)

Synonyms and Secondary IDs
Synonym(s)
A22 ASPARTIC ENDOPEPTIDASES
A22P
A22
Secondary FlyBase ID(s)
References (6)