FB2025_01 , released February 20, 2025
Gene Group: ATP-DEPENDENT SERINE ENDOPEPTIDASES
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General Information
Name
ATP-DEPENDENT SERINE ENDOPEPTIDASES
Species
D. melanogaster
Symbol
S14-16P
FlyBase ID
FBgg0001434
Date last reviewed
2020-06-08
Number of members
2
Description
Description
ATP-dependent serine endopeptidases belong to MEROPS families S14 and S16 and catalyse the hydrolysis of proteins in the presence of ATP. They include the peptidase subunit of the Clp complex (S14 family) and the Lon protease (S16 family), which mediate the selective degradation of polypeptides in the mitochondrial matrix. (Adapted from FBrf0236413 and FBrf0240421.)
Notes on Group
Source Material
The ATP-DEPENDENT SERINE ENDOPEPTIDASES Gene Group has been compiled using the following publication(s): Pareek et al., 2018, Matsushima et al., 2017, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
serine-type endopeptidase activity
ATP-dependent peptidase activity
Biological Process
proteolysis
Cellular Component
mitochondrial matrix
Enzymatic activity
Enzyme name (EC)
3.4.21.-
Related Gene Groups
Parent group(s)
SERINE PEPTIDASES
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ClpP
Caseinolytic protease proteolytic subunit
(Pareek et al., 2018, FlyBase, 2017-, Matsushima et al., 2017, Rawlings and Barrett, 1996-)
Lon
Lon protease
(Pareek et al., 2018, FlyBase, 2017-, Matsushima et al., 2017, Rawlings and Barrett, 1996-)
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Family S14](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=s14)

[MEROPS Family S16](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=s16)

Synonyms and Secondary IDs
Synonym(s)
ATP-DEPENDENT SERINE ENDOPEPTIDASES
S14-16P
S14-16
Secondary FlyBase ID(s)
References (5)