Matrix metalloproteases (MMPs) belong to MEROPS family M10 and also to the group of peptidases known as the "metzincins", due to a conserved methionine C-terminal to the zinc ligands. They are secreted proteins that function extracellularly. They play important roles in the degradation of extracellular matrix proteins and altering signaling pathways. There are over 20 MMPs in vertebrates, but only 2 in D. melanogaster, which cleave different substrates. (Adapted from FBrf0235071 and FBrf0239469.)