FB2025_01 , released February 20, 2025
Gene Group: ECDYSTEROID KINASE-LIKE
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General Information
Name
ECDYSTEROID KINASE-LIKE
Species
D. melanogaster
Symbol
ECKL
FlyBase ID
FBgg0001618
Date last reviewed
2021-09-13
Number of members
51
Description
Description
Members of the arthropod-specific ecdysteroid kinase-like (EcKL) gene family are hypothesised to encode detoxicative kinases responsible for detoxification-by-phosphorylation. They are predicted to conjugate phosphate to secondary alcohols, using ATP as a phosphodonor. However, so far only one EcKL enzyme (ecdysteroid 22-kinase from Bombyx mori) has been characterised, phosphorylating ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates. (Adapted from FBrf0246376.)
Notes on Group

Ecdysteroid kinase-like members are defined by InterPro entry IPR004119.

CR13656, CR31562 and CR43310 are ECKL pseudogenes and are omitted from this group (see FBrf0246376).

Source Material
The ECDYSTEROID KINASE-LIKE Gene Group has been compiled using the following publication(s): Scanlan et al., 2022 and Scanlan et al., 2020 .
Key Gene Ontology (GO) terms
Molecular Function
ecdysteroid 22-kinase activity
Biological Process
detoxification
Cellular Component
Related Gene Groups
Parent group(s)
KINASES
Members (51)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG2004
(Scanlan et al., 2020)
CG5126
(Scanlan et al., 2020)
CG5644
Dro42-0
(Scanlan et al., 2020)
CG6830
Dro24-1
(Scanlan et al., 2020)
CG6834
(Scanlan et al., 2020)
CG6908
(Scanlan et al., 2020)
CG7135
(Scanlan et al., 2020)
CG9259
Dro33-0
(Scanlan et al., 2020)
CG9497
(Scanlan et al., 2020)
CG9498
(Scanlan et al., 2020)
CG10513
Dro2-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG10514
Dro3-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG10550
Dro13-1
(Scanlan et al., 2022, Scanlan et al., 2020)
CG10553
Dro17-1
(Scanlan et al., 2022, Scanlan et al., 2020)
CG10559
Dro16-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG10560
Dro17-3
(Scanlan et al., 2022, Scanlan et al., 2020)
CG10562
Dro18-1
(Scanlan et al., 2022, Scanlan et al., 2020)
CG11878
Dro1-5
(Scanlan et al., 2022, Scanlan et al., 2020)
CG11889
Dro1-3
(Scanlan et al., 2022, Scanlan et al., 2020)
CG11891
Dro1-4
(Scanlan et al., 2022, Scanlan et al., 2020)
CG11892
Dro4-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG11893
Dro5-6
(Scanlan et al., 2022, Scanlan et al., 2020)
CG13360
EG:34F3.5
(Scanlan et al., 2020)
CG13658
Dro5-5
(Scanlan et al., 2022, Scanlan et al., 2020)
CG13659
Dro5-7
(Scanlan et al., 2022, Scanlan et al., 2020)
CG14314
Dro40-0
(Scanlan et al., 2020)
CG16898
(Scanlan et al., 2020)
CG18765
(Scanlan et al., 2020)
CG31087
Dro15-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31097
Dro10-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31098
Dro8-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31099
Dro14-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31102
Dro9-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31104
Dro5-2
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31288
Dro11-0
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31300
Dro5-1
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31370
Dro5-8
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31380
(Scanlan et al., 2020)
CG31436
Dro5-10
(Scanlan et al., 2022, Scanlan et al., 2020)
CG31974
(Scanlan et al., 2020)
CG31975
(Scanlan et al., 2020)
CG32195
(Scanlan et al., 2020)
CG33301
(Scanlan et al., 2020)
CG33509
(Scanlan et al., 2020)
CG33510
(Scanlan et al., 2020)
CG33511
(Scanlan et al., 2020)
CHKov1
CHK domain ov1
ref(3)D, Dro18-2
(Scanlan et al., 2022, Scanlan et al., 2020)
CHKov2
CHK domain ov2
Dro19-0, ref(3)D
(Scanlan et al., 2022, Scanlan et al., 2020)
JhI-26
Juvenile hormone-inducible protein 26
Dro46-0
(Scanlan et al., 2020)
pkm
Pinkman
(Scanlan et al., 2020)
wall
wallflower
(Scanlan et al., 2020)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
ECKL
ECDYSTEROID KINASE-LIKE
Secondary FlyBase ID(s)
References (3)