FB2025_02 , released April 17, 2025
Gene Group: DIACYLGLYCEROL O-ACYLTRANSFERASES
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General Information
Name
DIACYLGLYCEROL O-ACYLTRANSFERASES
Species
D. melanogaster
Symbol
DGAT
FlyBase ID
FBgg0001627
Date last reviewed
2023-02-08
Number of members
4
Description
Description
Diacylglycerol O-acyltransferases (DGATs) catalyze the final and only dedicated step in triacylglycerol biosynthesis, converting diacylglycerol into triacylglycerol. DGATs fall into two distinct families. In D. melanogaster, the DGAT1 family is represented by a single member (mdy), whereas the DGAT2 (or DAGAT) family comprises 3 members encoded in a tandem array. (Adapted from FBrf0218870.)
Notes on Group

None of the three D. melanogaster DAGAT family members has been functionally characterized - it is possible that one or more of these proteins has no DGAT but rather has monoacylglycerol O-acyltransferase activity and accordingly catalyzes the first step of the monoacylglycerol pathway of triacylglycerol synthesis (FBrf0218870).

Source Material
The DIACYLGLYCEROL O-ACYLTRANSFERASES Gene Group has been compiled using the following publication(s): Toprak et al., 2020 and Kuhnlein, 2012 .
Key Gene Ontology (GO) terms
Molecular Function
diacylglycerol O-acyltransferase activity
Biological Process
triglyceride biosynthetic process
Cellular Component
Enzymatic activity
Enzyme name (EC)
diacylglycerol O-acyltransferase (2.3.1.20)
Related Gene Groups
Parent group(s)
NON-AMINOACYL ACYLTRANSFERASES
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
DGAT
DIACYLGLYCEROL O-ACYLTRANSFERASES
Secondary FlyBase ID(s)
References (4)