FB2025_01 , released February 20, 2025
Gene Group: SERINE-TYPE OTU DEUBIQUITINASES
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General Information
Name
SERINE-TYPE OTU DEUBIQUITINASES
Species
D. melanogaster
Symbol
OTU-DUB-S
FlyBase ID
FBgg0001679
Date last reviewed
2021-02-05
Number of members
2
Description
Description
Serine-type OTU deubiquitinases belong to the ovarian tumour (OTU) sub-family of deubiquitinases and catalyze the removal of ubiquitin from ubiquitin chains and ubiquitinated proteins. They have a central serine in the catalytic triad within their OTU domain. (Adapted from FBrf0230214, FBrf0235835.)
Notes on Group

otu and CG3251 both carry a serine residue instead of a cysteine in the catalytic triad and were shown to lack deubiquitinase activity in vitro (FBrf0230214). Subsequently, FBrf0235835 and FBrf0242056 demonstrated that otu still retains deubiquitinase activity, but with reduced catalytic efficiency.

Source Material
The SERINE-TYPE OTU DEUBIQUITINASES Gene Group has been compiled using the following publication(s): Páhi et al., 2022, Badmos et al., 2021, Louis et al., 2015, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
deubiquitinase activity
Biological Process
protein deubiquitination
Cellular Component
Related Gene Groups
Parent group(s)
DEUBIQUITINASES
SERINE PEPTIDASES
Other related group(s)
CYSTEINE-TYPE OTU DEUBIQUITINASES
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG3251
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Louis et al., 2015, Zhang et al., 2012, Rawlings and Barrett, 1996-)
otu
ovarian tumor
fs(1)231, K, fs(1)M101
(Páhi et al., 2022, Badmos et al., 2021, FlyBase, 2017-, Louis et al., 2015, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Rawlings and Barrett, 1996-)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
OTU-DUB-S
SERINE-TYPE OTU DEUBIQUITINASES
Secondary FlyBase ID(s)
References (9)