Complex: MITOCHONDRIAL COMPLEX I - TESTIS-SPECIFIC VARIANT

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Complex: MITOCHONDRIAL COMPLEX I - TESTIS-SPECIFIC VARIANT

General Information

Name

MITOCHONDRIAL COMPLEX I - TESTIS-SPECIFIC VARIANT

Species

D. melanogaster

Symbol

MCI-T

FlyBase ID

FBgg0001837

Date last reviewed

2024-09-16

Number of members

45

Description

Description

Mitochondrial Complex I is the first and largest holoenzyme of the mitochondrial electron transport chain. It oxidizes NADH from the tricarboxylic acid cycle and β oxidation of fatty acids, reduces ubiquinone and transports protons across the inner membrane, contributing to the proton-motive force. It is also involved in the cellular production of reactive oxygen species. Fourteen distinct subunits form the catalytic centers of the enzyme as they are directly involved in transferring electrons from NADH to ubiquinone, or for generation of the membrane potential. (Adapted from PMID:23527692 and FBrf0244962.)

Notes on Group

Source Material

The MITOCHONDRIAL COMPLEX I - TESTIS-SPECIFIC VARIANT Gene Group has been compiled using the following publication(s): Agip et al., 2023, Rhooms et al., 2020, and Fearnley and Walker, 1992 .

Key Gene Ontology (GO) terms

Molecular Function

NADH dehydrogenase (ubiquinone) activity

Biological Process

mitochondrial electron transport, NADH to ubiquinone

Cellular Component

respiratory chain complex I

mitochondrial inner membrane

Enzymatic activity

Enzyme name (EC)

NADH:ubiquinone reductase (H(+)-translocating) (7.1.1.2)

Related Gene Groups

Parent group(s)

MITOCHONDRIAL OXPHOS COMPLEX VARIANTS

Other related group(s)

MITOCHONDRIAL COMPLEX I SUBUNITS

Members (45)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(Rhooms et al., 2020)

mitochondrial NADH-ubiquinone oxidoreductase chain 1

ND1, dND1, ND-1, nad1

(Rhooms et al., 2020, Fearnley and Walker, 1992)

mitochondrial NADH-ubiquinone oxidoreductase chain 2

ND2, dND2, NADH dehydrogenase subunit 2, nad2

(Rhooms et al., 2020, Fearnley and Walker, 1992)

mitochondrial NADH-ubiquinone oxidoreductase chain 3

ND3, dND3

(Rhooms et al., 2020, Fearnley and Walker, 1992)

mitochondrial NADH-ubiquinone oxidoreductase chain 4

ND4, dND4, BEST:CK00534, nad4

(Rhooms et al., 2020, Fearnley and Walker, 1992)

mitochondrial NADH-ubiquinone oxidoreductase chain 4L

ND4L, dND4L

(Rhooms et al., 2020, Fearnley and Walker, 1992)

mitochondrial NADH-ubiquinone oxidoreductase chain 5

ND5, dND5, nad5

(Rhooms et al., 2020, Fearnley and Walker, 1992)

mitochondrial NADH-ubiquinone oxidoreductase chain 6

ND6, dND6, nad6

(Rhooms et al., 2020, Fearnley and Walker, 1992)

NADH dehydrogenase (ubiquinone) 13 kDa A subunit

dNDUFS6

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 13 kDa B subunit

dNDUFA5, NDUFA5

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 15 kDa subunit

dNDUFS5, NDUFS5

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 18 kDa subunit

dNDUFS4, NDUFS4

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 19 kDa subunit

dNDUFA8, NDUFA8

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 20 kDa subunit-like

ND20-like, NADH: ubiquinone oxidoreductase-like, 20kDa subunit

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 23 kDa subunit

ND23, dNDUFS8, NADH:ubiquinone reductase 23kD subunit precursor, NDUFS8

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 24 kDa subunit-like

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 30 kDa subunit

NDUFS3, dNDUFS3, ND30, C-I30

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 39 kDa subunit

dNDUFA9, NDUFA9

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 42 kDa subunit

ND42, NADH:ubiquinone reductase 42kD subunit precursor, NdufA10, dNDUFA10

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 49 kDa subunit-like

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 1

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) 75 kDa subunit

ND75, NDUFS1, NADH:ubiquinone reductase 75kD subunit precursor

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) acyl carrier protein

mtacp1, mtACP, NADH-ubiquinone oxidoreductase acyl-carrier subunit, mitochondrial acyl carrier protein 1, dNDUFAB1

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) AGGG subunit

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) ASHI subunit

dNDUFB8, NDUFB8

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B8 subunit

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B12 subunit

dNDUFB3, NDUFB3

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B14 subunit

dNDUFA6, NDUFA6

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B14.5 A subunit-like

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B14.5 B subunit

dNDUFC2

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B14.7 subunit

dNDUFA11, NDUFA11

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B15 subunit

dNDUFB4

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B16.6 subunit

dNDUFA13, NDUFA13

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B17 subunit

l(2)35Di, BG:DS09217.1, dNDUFB6, lethal (2) 35Di, NDUFB6

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B17.2 subunit

dNDUFA12, NDUFA12

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B18 subunit

dNDUFB7

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) B22 subunit

dNDUFB9

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) MNLL subunit

NDUFB1, dNDUFB1

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) MWFE subunit

dNDUFA1

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) PDSW subunit

Pdsw, dNDUFB10, l(2)k10101

(Rhooms et al., 2020)

NADH dehydrogenase (ubiquinone) SGDH subunit

l(3)neo18, dNDUFB5, lethal (3) neo18, NDUFB5

(Rhooms et al., 2020)

NADH:ubiquinone oxidoreductase subunit A3

(Agip et al., 2023)

NADH:ubiquinone oxidoreductase subunit V3

dNDUFV3, BcDNA:RH44935

(Rhooms et al., 2020)

NP15.6

dNDUFB11

(Rhooms et al., 2020)

External Data

Equivalent Group(s)

Fly Mitochondrial respiratory chain complex I, testis-specific variant (Complex Portal)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

MCI-T

MITOCHONDRIAL COMPLEX I - TESTIS-SPECIFIC VARIANT

Secondary FlyBase ID(s)

References (4)

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