FB2025_01 , released February 20, 2025
Complex: MITOCHONDRIAL COMPLEX V
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General Information
Name
MITOCHONDRIAL COMPLEX V
Species
D. melanogaster
Symbol
MCV-U
FlyBase ID
FBgg0001849
Date last reviewed
2024-09-16
Number of members
16
Description
Description
Mitochondrial ATP synthase (Complex V) synthesizes ATP from ADP and inorganic phosphate using the energy provided by the proton electrochemical gradient (proton-motive force) across the inner mitochondrial membrane generated by electron transport complexes of the respiratory chain. It is an F-type ATPase and consists of two structural domains: the F1 sector, a soluble portion situated in the mitochondrial matrix, and the F0 sector, which spans the inner mitochondrial membrane. Protons pass from the inter membrane space to the matrix through F0, which transfers the energy created by the proton-motive force to F1 where ADP is phosphorylated to ATP using a rotational mechanism. (Adapted from PMID:23356252 and PMID:21874297).
Notes on Group
Source Material
The MITOCHONDRIAL COMPLEX V Gene Group has been compiled using the following publication(s): Marygold, 2021.2.24, Ilinsky, 2013, and Tripoli et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
proton-transporting ATP synthase activity, rotational mechanism
Biological Process
proton motive force-driven ATP synthesis
Cellular Component
proton-transporting ATP synthase complex
mitochondrial inner membrane
Related Gene Groups
Parent group(s)
MITOCHONDRIAL OXPHOS COMPLEX VARIANTS
Other related group(s)
MITOCHONDRIAL COMPLEX V SUBUNITS
Members (16)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ATPsynB
ATP synthase, subunit B
ATPsyn-b, ATP synthase B chain
(Tripoli et al., 2005)
ATPsynβ
ATP synthase, β subunit
ATPsyn-beta, ATPsyn-β, ATP synthase-β, ATP synthase β subunit, ATPB
(Tripoli et al., 2005)
ATPsynC
ATP synthase, subunit C
(Tripoli et al., 2005)
ATPsynCF6
ATP synthase, coupling factor 6
ATPsyn-Cf6, ATPase coupling factor 6
(Tripoli et al., 2005)
ATPsynD
ATP synthase, subunit D
ATPsyn-d, ATP synthase D chain
(Tripoli et al., 2005)
ATPsynδ
ATP synthase, δ subunit
l(1)G0230, lethal (1) G0230, l (1) G0230
(Tripoli et al., 2005)
ATPsynE
ATP synthase, subunit E
c550
(Tripoli et al., 2005)
ATPsynF
ATP synthase, subunit F
(Tripoli et al., 2005)
ATPsynG
ATP synthase, subunit G
l(2)06225, lethal (2) 06225
(Tripoli et al., 2005)
ATPsynγ
ATP synthase, γ subunit
ATPsyn-gamma, ATPsyn-γ, ATP synthase-gamma chain
(Tripoli et al., 2005)
ATPsynO
ATP synthase, oligomycin sensitivity conferring protein
Oscp, Oligomycin sensitivity-conferring protein, ATP synthase OSCP
(Tripoli et al., 2005)
blw
bellwether
ATP5A, ATPsyn-α, Complex Vα, C-V-α, ATPsynα
(Tripoli et al., 2005)
mt:ATPase6
mitochondrial ATPase subunit 6
ATP6, ATPase6, mt:ATP6, mtATP6, ATPase 6
(Ilinsky, 2013)
mt:ATPase8
mitochondrial ATPase subunit 8
ATP8, ATPase8, mt:ATP8
(Ilinsky, 2013)
Neb-cGP
Neb-cGP
pncr006:X
(Marygold, 2021.2.24)
sun
stunted
ATP synthase epsilon chain
(Tripoli et al., 2005)
External Data
Synonyms and Secondary IDs
Synonym(s)
MCV-U
MITOCHONDRIAL COMPLEX V
ATP synthase
Secondary FlyBase ID(s)
References (4)