FB2025_01 , released February 20, 2025
Complex: TESTIS-SPECIFIC MEIOTIC ARREST COMPLEX
Open Close
General Information
Name
TESTIS-SPECIFIC MEIOTIC ARREST COMPLEX
Species
D. melanogaster
Symbol
TMAC
FlyBase ID
FBgg0001985
Date last reviewed
2024-06-27
Number of members
6
Description
Description
The testis-specific meiotic arrest complex (tMAC) is a MuvB-type transcriptional activator complex required for meiosis and spermiogenesis. (Adapted from FBrf0238569.)
Notes on Group

The TESTIS-SPECIFIC MEIOTIC ARREST COMPLEX was sourced from Complex Portal, curated by EMBL-EBI.

The lin-52 paralog wuc interacts with tMAC. It has not been included as a tMAC subunit as it has a transcriptional repressive rather than activatory role in testis (FBrf0213964).

Source Material
The TESTIS-SPECIFIC MEIOTIC ARREST COMPLEX Gene Group has been compiled using the following publication(s): Laktionov et al., 2018, Doggett et al., 2011, and Beall et al., 2007 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-binding transcription activator activity, RNA polymerase II-specific
sequence-specific double-stranded DNA binding
Biological Process
positive regulation of transcription by RNA polymerase II
Cellular Component
RNA polymerase II transcription regulator complex
nucleus
Related Gene Groups
Parent group(s)
MUVB COMPLEX GROUPS
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
aly
always early
tMAC
(Laktionov et al., 2018, Doggett et al., 2011, Beall et al., 2007)
Caf1-55
Chromatin assembly factor 1, p55 subunit
p55, Caf1, NURF, NURF55, NURF-55
(Laktionov et al., 2018, Beall et al., 2007)
comr
cookie monster
zab
(Laktionov et al., 2018, Doggett et al., 2011, Beall et al., 2007)
mip40
Myb-interacting protein 40
(Laktionov et al., 2018, Doggett et al., 2011, Beall et al., 2007)
tomb
tombola
(Laktionov et al., 2018, Doggett et al., 2011, Beall et al., 2007)
topi
matotopetli
(Laktionov et al., 2018, Doggett et al., 2011, Beall et al., 2007)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TMAC
TESTIS-SPECIFIC MEIOTIC ARREST COMPLEX
Secondary FlyBase ID(s)
References (4)