The isocitrate dehydrogenase complex catalyzes the NAD-dependent oxidative decarboxylation of isocitrate to α-ketoglutarate in the rate-limiting step of the tricarboxylic acid cycle in the mitochondrial matrix. It consists of three types of subunits in the ratio of 2 alpha:1 beta:1 gamma, and exists as a heterotetramer composed of the alpha-beta and alpha-gamma heterodimers. The alpha subunit provides the catalytic activity, the gamma subunit plays a regulatory role to activate the holoenzyme, and the beta subunit has a structural role to facilitate assembly of the holoenzyme. (Adapted from PMID:28139779.)
Notes on Group
Only the ubiquitously expressed isocitrate dehydrogenase complex subunits are included. Idh3a has two testis-specific paralogs CG3483 and CG32026.
