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Gene Dmel\a

General Information
Symbol	Dmel\a	Species	D. melanogaster
Name	arc	Annotation symbol	CG6741
Feature type	protein_coding_gene	FlyBase ID	FBgn0000008
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	CG13505, Arc
Genomic Location
Chromosome (arm)	2R	Recombination map	2-99.2
Cytogenetic map	58C1-58C5	Sequence location	2R:18,024,494..18,060,346 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene arc is referred to in FlyBase by the symbol Dmel\a (CG6741, FBgn0000008). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: compound eye development. 35 alleles are reported. The phenotypes of these alleles are annotated with: ommatidium; crossvein; macrochaeta; eye; posterior scutellar bristle; wing. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: PDZ/DHR/GLGF. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1633746_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of a. Gene sequence location is 2R:18024494..18060346.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	a: arc a: arc From Bridges and Morgan, 1919, Carnegie Inst. Washington Publ. No. 278: 148. Wings broader; bent downward in slight, even arc; edges drawn down to diamond shape. Sometimes in stock, wings are bent upward instead of downward. Crossveins closer together. RK2. aba: arc-broad angular Wings broader and shorter than wild type, blunt at the tip. Frequently shows upturned posterior scutellar bristles. In combination with svrpoi, produces soft blistered wing. Other interactions described by Goldschmidt, 1945, table 74. Wing grows in pupal stage to full length and then retracts, possibly with histolysis [Goldschmidt, 1934, Z. Indukt. Abstamm. Vererbungsl. 69: 38-131 (fig.)]. RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN27321 HFA04668 HFA04667
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58C1-58C5   Limits computationally determined from genome sequence between P{EP}CG6393EP2457 and P{PZ}ari-207768
Experimentally Determined Cytological Location
Cytogenetic map Notes References 58C-58D     (Liu, 1999.9.21)
Experimentally Determined Recombination Data
Location	2-99.2 (Meyer, 1963) 2- (Goldschmidt, 1944)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\a for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	5' UTR(s) contain an ORF that is conserved among Drosophila species;potential peptide 13 aa in length; no initiating methionine.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) a-RA FBtr0071763  NM_166514   4831   1329 a-RB FBtr0071764  NM_079902   5180   1329 a-RC FBtr0100521  NM_001014543   4644   1329
Additional Transcript Data & Comments
Reported size (kB)	5.5, 4.826, 4.644 (compiled cDNA) (Liu and Lengyel, 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein a-PA   FBpp0071677   142.9   1329   9.85     NP_726168   AAF46810 a-PB   FBpp0071678   142.9   1329   9.85     NP_524641   AAF46809 a-PC   FBpp0099961   142.9   1329   9.85     NP_001014543   AAX52678
Additional Polypeptide Data & Comments
Reported size (kDa)	1329 (aa); 143 (kD predicted) (Liu and Lengyel, 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PDZ/DHR/GLGF (IPR001478)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF46809   AE013599 AAF46810   AE013599 AAX52678   AF188473 AAF37816   AF188474 AAF37817   AF188475 AAF37818   AI389852   AW940815   AY058433 AAL13662   BE977768   BP552580   CO191253   CO271571   CO283667   CO315193   CO326074   CO343315   CZ466616   CZ466617   CZ467660   CZ467661   CZ488936   CZ488937   EC060308   EC067679   EC076790   EC197620   EC199834   EC203346   EC212957   EC237539   EC253698   EL873339   ES696122
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W283
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval salivary gland   (Liu and Lengyel, 2000) embryonic/larval foregut   (Liu and Lengyel, 2000) embryonic stage | early   organism | anterior posterior gradient   (Liu and Lengyel, 2000) embryonic stage 6 -- 17   posterior midgut primordium   (Liu and Lengyel, 2000) embryonic stage 10 -- 17   Malpighian tubule   (Liu and Lengyel, 2000) embryonic stage 13 -- 17   embryonic/larval hindgut   (Liu and Lengyel, 2000) third instar larval stage   morphogenetic furrow   (Liu and Lengyel, 2000) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Liu and Lengyel, 2000)
Additional Descriptive Data
	a transcripts are distributed uniformly in the embryo shortly after egg laying. This maternal RNA is rapidly converted to an anterior-posterior gradient. a transcripts are expressed dynamically in the embryo in regions that are about to or in the process of undergoing morphogenetic movements. Zygotic a transcripts are first detected in the posterior midgut primordium, prior to and during invagination. They are detected in the Malpighian tubule primordium prior to evagination of the tubule buds and during evagination and elongation. They are also found in the hindgut, foregut, salivary gland, and trachea after they have formed and while they are elongating. In larvae, a transcripts are expressed in repeating clusters of cells along the morphogenetic furrow. (Liu and Lengyel, 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval salivary gland   (Liu and Lengyel, 2000) embryonic/larval foregut   (Liu and Lengyel, 2000) embryonic stage 6 -- 17   posterior midgut primordium   (Liu and Lengyel, 2000) embryonic stage 10 -- 17   Malpighian tubule   (Liu and Lengyel, 2000) embryonic stage 14 -- 17   embryonic/larval hindgut   (Liu and Lengyel, 2000) third instar larval stage   morphogenetic furrow   (Liu and Lengyel, 2000) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	a protein is found on the apical side of expressing cells and has been localized to the adherens junction. (Liu and Lengyel, 2000)
Marker for
Subcellular Localization
CV Term	adherens junction (Liu and Lengyel, 2000)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000008    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000008 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000008 expression level Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    571 embryo 04-06hr    381 embryo 06-08hr    429 embryo 08-10hr    751 embryo 10-12hr    1567 embryo 12-14hr    2078 embryo 14-16hr    1847 embryo 16-18hr    749 embryo 18-20hr    931 embryo 20-22hr    803 embryo 22-24hr    744 larva L1    417 larva L2    381 larva L3 12hr old    236 larva L3 puffstage 1-2    150 larva L3 puffstage 3-6    411 larva L3 puffstage 7-9    1026 white prepupae new    1316 white prepupae 12hr    1441 white prepupae 24hr    1941 pupae 2d postWPP    3248 pupae 3d postWPP    951 pupae 4d postWPP    619 adult male 01day    402 adult male 05day    488 adult male 30day    572 adult female 01day    713 adult female 05day    768 adult female 30day    788 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1630) embryo 02-04hr  (571) embryo 04-06hr  (381) embryo 06-08hr  (429) embryo 08-10hr  (751) embryo 10-12hr  (1567) embryo 12-14hr  (2078) embryo 14-16hr  (1847) embryo 16-18hr  (749) embryo 18-20hr  (931) embryo 20-22hr  (803) embryo 22-24hr  (744) larva L1  (417) larva L2  (381) larva L3 12hr old  (236) larva L3 puffstage 1-2  (150) larva L3 puffstage 3-6  (411) larva L3 puffstage 7-9  (1026) white prepupae new  (1316) white prepupae 12hr  (1441) white prepupae 24hr  (1941) pupae 2d postWPP  (3248) pupae 3d postWPP  (951) pupae 4d postWPP  (619) adult male 01day  (402) adult male 05day  (488) adult male 30day  (572) adult female 01day  (713) adult female 05day  (768) adult female 30day  (788) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1630) embryo 02-04hr    571 embryo 04-06hr    381 embryo 06-08hr    429 embryo 08-10hr    751 embryo 10-12hr  (1567) embryo 12-14hr  (2078) embryo 14-16hr  (1847) embryo 16-18hr    749 embryo 18-20hr    931 embryo 20-22hr    803 embryo 22-24hr    744 larva L1    417 larva L2    381 larva L3 12hr old    236 larva L3 puffstage 1-2    150 larva L3 puffstage 3-6    411 larva L3 puffstage 7-9    1026 white prepupae new    1316 white prepupae 12hr  1441 white prepupae 24hr  (1941) pupae 2d postWPP  (3248) pupae 3d postWPP    951 pupae 4d postWPP    619 adult male 01day    402 adult male 05day    488 adult male 30day    572 adult female 01day    713 adult female 05day    768 adult female 30day    788 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    571 embryo 04-06hr    381 embryo 06-08hr    429 embryo 08-10hr    751 embryo 10-12hr    1567 embryo 12-14hr    2078 embryo 14-16hr    1847 embryo 16-18hr    749 embryo 18-20hr    931 embryo 20-22hr    803 embryo 22-24hr    744 larva L1    417 larva L2    381 larva L3 12hr old    236 larva L3 puffstage 1-2    150 larva L3 puffstage 3-6    411 larva L3 puffstage 7-9    1026 white prepupae new    1316 white prepupae 12hr    1441 white prepupae 24hr    1941 pupae 2d postWPP    3248 pupae 3d postWPP    951 pupae 4d postWPP    619 adult male 01day    402 adult male 05day    488 adult male 30day    572 adult female 01day    713 adult female 05day    768 adult female 30day    788 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    571 embryo 04-06hr    381 embryo 06-08hr    429 embryo 08-10hr    751 embryo 10-12hr    1567 embryo 12-14hr    2078 embryo 14-16hr    1847 embryo 16-18hr    749 embryo 18-20hr    931 embryo 20-22hr    803 embryo 22-24hr    744 larva L1    417 larva L2    381 larva L3 12hr old    236 larva L3 puffstage 1-2    150 larva L3 puffstage 3-6    411 larva L3 puffstage 7-9    1026 white prepupae new    1316 white prepupae 12hr    1441 white prepupae 24hr    1941 pupae 2d postWPP    3248 pupae 3d postWPP    951 pupae 4d postWPP    619 adult male 01day    402 adult male 05day    488 adult male 30day    572 adult female 01day    713 adult female 05day    768 adult female 30day    788 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000008 expression level Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    571 embryo 04-06hr    381 embryo 06-08hr    429 embryo 08-10hr    751 embryo 10-12hr    1567 embryo 12-14hr    2078 embryo 14-16hr    1847 embryo 16-18hr    749 embryo 18-20hr    931 embryo 20-22hr    803 embryo 22-24hr    744 larva L1    417 larva L2    381 larva L3 12hr old    236 larva L3 puffstage 1-2    150 larva L3 puffstage 3-6    411 larva L3 puffstage 7-9    1026 white prepupae new    1316 white prepupae 12hr    1441 white prepupae 24hr    1941 pupae 2d postWPP    3248 pupae 3d postWPP    951 pupae 4d postWPP    619 adult male 01day    402 adult male 05day    488 adult male 30day    572 adult female 01day    713 adult female 05day    768 adult female 30day    788 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1630) embryo 02-04hr  (571) embryo 04-06hr  (381) embryo 06-08hr  (429) embryo 08-10hr  (751) embryo 10-12hr  (1567) embryo 12-14hr  (2078) embryo 14-16hr  (1847) embryo 16-18hr  (749) embryo 18-20hr  (931) embryo 20-22hr  (803) embryo 22-24hr  (744) larva L1  (417) larva L2  (381) larva L3 12hr old  (236) larva L3 puffstage 1-2  (150) larva L3 puffstage 3-6  (411) larva L3 puffstage 7-9  (1026) white prepupae new  (1316) white prepupae 12hr  (1441) white prepupae 24hr  (1941) pupae 2d postWPP  (3248) pupae 3d postWPP  (951) pupae 4d postWPP  (619) adult male 01day  (402) adult male 05day  (488) adult male 30day  (572) adult female 01day  (713) adult female 05day  (768) adult female 30day  (788) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1630 embryo 02-04hr    571 embryo 04-06hr    381 embryo 06-08hr    429 embryo 08-10hr    751 embryo 10-12hr  1567 embryo 12-14hr  2078 embryo 14-16hr  1847 embryo 16-18hr    749 embryo 18-20hr    931 embryo 20-22hr    803 embryo 22-24hr    744 larva L1    417 larva L2    381 larva L3 12hr old    236 larva L3 puffstage 1-2    150 larva L3 puffstage 3-6    411 larva L3 puffstage 7-9    1026 white prepupae new    1316 white prepupae 12hr  1441 white prepupae 24hr  1941 pupae 2d postWPP  (3248) pupae 3d postWPP    951 pupae 4d postWPP    619 adult male 01day    402 adult male 05day    488 adult male 30day    572 adult female 01day    713 adult female 05day    768 adult female 30day    788 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    571 embryo 04-06hr    381 embryo 06-08hr    429 embryo 08-10hr    751 embryo 10-12hr    1567 embryo 12-14hr    2078 embryo 14-16hr    1847 embryo 16-18hr    749 embryo 18-20hr    931 embryo 20-22hr    803 embryo 22-24hr    744 larva L1    417 larva L2    381 larva L3 12hr old    236 larva L3 puffstage 1-2    150 larva L3 puffstage 3-6    411 larva L3 puffstage 7-9    1026 white prepupae new    1316 white prepupae 12hr    1441 white prepupae 24hr    1941 pupae 2d postWPP    3248 pupae 3d postWPP    951 pupae 4d postWPP    619 adult male 01day    402 adult male 05day    488 adult male 30day    572 adult female 01day    713 adult female 05day    768 adult female 30day    788 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    571 embryo 04-06hr    381 embryo 06-08hr    429 embryo 08-10hr    751 embryo 10-12hr    1567 embryo 12-14hr    2078 embryo 14-16hr    1847 embryo 16-18hr    749 embryo 18-20hr    931 embryo 20-22hr    803 embryo 22-24hr    744 larva L1    417 larva L2    381 larva L3 12hr old    236 larva L3 puffstage 1-2    150 larva L3 puffstage 3-6    411 larva L3 puffstage 7-9    1026 white prepupae new    1316 white prepupae 12hr    1441 white prepupae 24hr    1941 pupae 2d postWPP    3248 pupae 3d postWPP    951 pupae 4d postWPP    619 adult male 01day    402 adult male 05day    488 adult male 30day    572 adult female 01day    713 adult female 05day    768 adult female 30day    788 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000008    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000008 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000008 expression level Tissue   Expression Level Larval Central Nervous System    33.35 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    49.1 Larval Fat Body    60.9 Larval Salivary Gland    9.6 Larval Trachea    32.3 Larval Carcass    40.15 Adult Head    34.4 Adult Eye    38 Adult Brain    70.4 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    20 Adult Midgut no informative data Adult Hindgut    11.4 Adult Malpighian Tubules no informative data Adult Fat Body    45.8 Adult Salivary Gland no informative data Adult Heart    19.65 Adult VirginFemale Spermatheca    95.5 Adult InseminatedFemale Spermatheca    97.1 Adult Ovary    103.6 Adult Testis no informative data Adult Male Accessory Gland    70.8 Adult Carcass    34.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    33.35 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    49.1 Larval Fat Body    60.9 Larval Salivary Gland    9.6 Larval Trachea    32.3 Larval Carcass    40.15 Adult Head    34.4 Adult Eye    38 Adult Brain    70.4 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    20 Adult Midgut no informative data Adult Hindgut    11.4 Adult Malpighian Tubules no informative data Adult Fat Body    45.8 Adult Salivary Gland no informative data Adult Heart    19.65 Adult VirginFemale Spermatheca    95.5 Adult InseminatedFemale Spermatheca    97.1 Adult Ovary    103.6 Adult Testis no informative data Adult Male Accessory Gland    70.8 Adult Carcass    34.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    33.35 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    49.1 Larval Fat Body    60.9 Larval Salivary Gland    9.6 Larval Trachea    32.3 Larval Carcass    40.15 Adult Head    34.4 Adult Eye    38 Adult Brain    70.4 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    20 Adult Midgut no informative data Adult Hindgut    11.4 Adult Malpighian Tubules no informative data Adult Fat Body    45.8 Adult Salivary Gland no informative data Adult Heart    19.65 Adult VirginFemale Spermatheca    95.5 Adult InseminatedFemale Spermatheca    97.1 Adult Ovary    103.6 Adult Testis no informative data Adult Male Accessory Gland    70.8 Adult Carcass    34.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    33.35 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    49.1 Larval Fat Body    60.9 Larval Salivary Gland    9.6 Larval Trachea    32.3 Larval Carcass    40.15 Adult Head    34.4 Adult Eye    38 Adult Brain    70.4 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    20 Adult Midgut no informative data Adult Hindgut    11.4 Adult Malpighian Tubules no informative data Adult Fat Body    45.8 Adult Salivary Gland no informative data Adult Heart    19.65 Adult VirginFemale Spermatheca    95.5 Adult InseminatedFemale Spermatheca    97.1 Adult Ovary    103.6 Adult Testis no informative data Adult Male Accessory Gland    70.8 Adult Carcass    34.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000008 expression level Tissue   Expression Level Larval Central Nervous System    33.35 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    49.1 Larval Fat Body    60.9 Larval Salivary Gland    9.6 Larval Trachea    32.3 Larval Carcass    40.15 Adult Head    34.4 Adult Eye    38 Adult Brain    70.4 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    20 Adult Midgut no informative data Adult Hindgut    11.4 Adult Malpighian Tubules no informative data Adult Fat Body    45.8 Adult Salivary Gland no informative data Adult Heart    19.65 Adult VirginFemale Spermatheca    95.5 Adult InseminatedFemale Spermatheca    97.1 Adult Ovary    103.6 Adult Testis no informative data Adult Male Accessory Gland    70.8 Adult Carcass    34.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    33.35 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    49.1 Larval Fat Body    60.9 Larval Salivary Gland    9.6 Larval Trachea    32.3 Larval Carcass    40.15 Adult Head    34.4 Adult Eye    38 Adult Brain    70.4 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    20 Adult Midgut no informative data Adult Hindgut    11.4 Adult Malpighian Tubules no informative data Adult Fat Body    45.8 Adult Salivary Gland no informative data Adult Heart    19.65 Adult VirginFemale Spermatheca    95.5 Adult InseminatedFemale Spermatheca    97.1 Adult Ovary    103.6 Adult Testis no informative data Adult Male Accessory Gland    70.8 Adult Carcass    34.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    33.35 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    49.1 Larval Fat Body    60.9 Larval Salivary Gland    9.6 Larval Trachea    32.3 Larval Carcass    40.15 Adult Head    34.4 Adult Eye    38 Adult Brain    70.4 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    20 Adult Midgut no informative data Adult Hindgut    11.4 Adult Malpighian Tubules no informative data Adult Fat Body    45.8 Adult Salivary Gland no informative data Adult Heart    19.65 Adult VirginFemale Spermatheca    95.5 Adult InseminatedFemale Spermatheca    97.1 Adult Ovary    103.6 Adult Testis no informative data Adult Male Accessory Gland    70.8 Adult Carcass    34.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    33.35 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    49.1 Larval Fat Body    60.9 Larval Salivary Gland    9.6 Larval Trachea    32.3 Larval Carcass    40.15 Adult Head    34.4 Adult Eye    38 Adult Brain    70.4 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    20 Adult Midgut no informative data Adult Hindgut    11.4 Adult Malpighian Tubules no informative data Adult Fat Body    45.8 Adult Salivary Gland no informative data Adult Heart    19.65 Adult VirginFemale Spermatheca    95.5 Adult InseminatedFemale Spermatheca    97.1 Adult Ovary    103.6 Adult Testis no informative data Adult Male Accessory Gland    70.8 Adult Carcass    34.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    34.4   NA  Eye    38   NA  Brain    70.4   33.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    23.2   NA  Crop    20   no informative data  Midgut    no informative data   no informative data  Hindgut    11.4   49.1  Malpighian Tubules    no informative data   60.9  Fat Body    45.8   9.6  Salivary Gland    no informative data   NA  Heart    19.65   32.3  Trachea    NA   NA  VirginFemale Spermatheca    95.5   NA  InseminatedFemale Spermatheca    97.1   NA  Ovary    103.6   NA  Testis    no informative data   NA  Male Accessory Gland    70.8   40.15  Carcass    34.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000008 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6741-RA GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0000008
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI ayUAS lethal | pupal stage, with Scer\GAL4pnr-MD237 aGD1369 lethal | recessive aBap2 aBay aEX3 aM60 viable aEM1 aEM15 aEM27 aEM50 Sterility Allele sterile | recessive aBay Other Phenotypes Allele visible aba1 aba2 aba4 aba abadb abar visible | dominant aBa aBapl aBaX aBay aM60 visible | recessive a1 aba4 aba aBaC abadb abar wild-type aba2 aba3 abadp Phenotype manifest in Allele crossvein a1 eye ak11011b eye, with Scer\GAL4Act5C.PI ayUAS eye, with Scer\GAL4GMR.PF ayUAS eye (with Df(2R)aEX1) a7 macrochaeta aBa ommatidium, with Scer\GAL4Act5C.PI ayUAS ommatidium (with Df(2R)aEX1) a7 posterior scutellar bristle aBa aBapl aba aba4 abadb wing a1 aBa aBaC aBaX aBapl aBay aba aba1 aba2 aba4 abadb abar ak11011b
Classical Alleles ( 34 )
For All Classical Alleles Show
Allele of a Class Mutagen Stocks Known lesion a1 spontaneous 8 -- aba spontaneous 1 -- ac00636 piggyBac transposase 1 -- ac02081 piggyBac transposase 1 -- ac07111 1 -- aEM1 ethyl methanesulfonate 1 -- af06262 piggyBac transposase 1 -- aG2432 P-element activity 1 -- ak11011b hypomorphic allele - genetic evidence P-element activity 1 Yes aKG05532 1 -- aMB06991 1 -- aNP1206 1 -- ayUAS gene conversion P-element activity 1 Yes a57e14 spontaneous 0 -- a7 X ray 0 Yes aba1 spontaneous 0 -- aba2 spontaneous 0 -- aba3 spontaneous 0 -- aba4 spontaneous 0 -- aBa spontaneous 0 -- aBaC spontaneous 0 -- abadb spontaneous 0 -- abadp spontaneous 0 -- aBap1 spontaneous 0 -- aBap2 spontaneous 0 -- aBapl spontaneous 0 -- abar spontaneous 0 -- aBaX X ray 0 -- aBay spontaneous 0 -- aEM15 ethyl methanesulfonate 0 -- aEM27 ethyl methanesulfonate 0 -- aEM50 ethyl methanesulfonate 0 -- aEX3 P-element activity 0 -- aM60 X ray 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of a Class Mutagen Stocks Known lesion aGD1369 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Not duplicated in	Dp(2;3)P
Disrupted in	Df(2R)a7 (Liu and Lengyel, 2000) Df(2R)aEX1 (Liu and Lengyel, 2000) Df(2R)aEX2 (Liu and Lengyel, 2000) Df(2R)a-ba2 (Goldschmidt, 1945, Goldschmidt, 1944) Df(2R)Exel6078 (Ryder, 2004.4.26) Df(2R)Exel7171 (Ryder, 2004.4.26) Df(2R)M58F (Bridges, 1937, Dunn and Mossige, 1937) In(2LR)aM60 (Meyer, 1963)
Not disrupted in	Df(2R)E3578 (BDGP Project Members, 1994-1999) Df(2R)nap16 (BDGP Project Members, 1994-1999) Df(2R)P (Bridges, 1937) Df(2R)ST1 (BDGP Project Members, 1994-1999) Df(2R)XE-916 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1369} NA reporter construct P{HLH54Fa-lacZ.Pelican} No characterization construct P{Sym-UAS-w} NA P{UASp-CTG.240} NA P{UASp-CTG.480} NA P{UAS-w.as} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}aMB06991 No P{GawB}aNP1206 No miscellaneous insertions P{SUPor-P}aKG05532 NA PBac{PB}ac00636 NA PBac{PB}ac02081 NA PBac{PB}ac07111 NA PBac{WH}af06262 NA insertion of enhancer trap P{lacW}ak11011b No insertion of mobile activating element P{EP}aG2432 NA P{Mae-UAS.6.11}ayUAS NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye development inferred from mutant phenotype (Liu and Lengyel, 2000)
Cellular Component
CV term Evidence References
adherens junction inferred from direct assay (Liu and Lengyel, 2000) apical plasma membrane inferred from direct assay (Liu and Lengyel, 2000)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
adherens junction non-traceable author statement (Liu, 1999.9.21)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions a allele Gene References unspecified svr
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68671 DroID - A comprehensive database of gene and protein interactions. • FBgn0000008 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43852
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11650 Dere\GG22167 Dgri\GH20556 Dmoj\GI18825 Dper\GL11782 Dpse\GA19824 Dsec\GM15888 Dvir\GJ21853 Dwil\GK19638 Dyak\GE14160
Curated drosophilid orthologs	Dpse\GA19824   Dsim\ar (Sturtevant, 1929)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004673-PA Aedes aegypti (mosquito) AGAP010808-PA Anopheles gambiae (mosquito) XP_392250.2 Apis mellifera (honey bee) BGIBMGA003506-PA Bombyx mori (silk worm) CN10325 Caenorhabditis brenneri (small nematode) ENSCAFP00000027923 Canis familiaris (dog) CPIJ017916 Culex pipens (mosquito) 162134 Hypsipyla robusta (cedar shoot borer) 25404 Monocosta brevicollis (choanoflagellate) ENSMODP00000025545 Monodelphis domestica (gray opossum) XP_001604752.1 Nasonia vitripennis (wasp) PHUM007643-PA Pediculus humanus (human body louse) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19238 NV10565 LH11947 FBgn0231782 FBgn0221636 FBgn0208971 FBgn0170804 JGI_V11_309940 FBgn0079820 FBgn0149391 FBgn0141564 FBgn0128019 FBgn0114341 FBgn0088690 CPIJ019766 CPIJ017917 CPIJ017916 ACYPI003804 GB10518 AGAP010808 AAEL004673 PHUM044040 GLEAN_01616
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Bloomington	1554 a1 px1 or1 7075 w*; P{lacW}ak11011b 25344 w1118; Mi{ET1}aMB06991 26995 y1 w*; P{EP}aG2432 312 hy1 a1 px1 sp1/SM1
Harvard	- PBac{PB}ac00636 - PBac{PB}ac02081 - PBac{PB}ac07111 - PBac{WH}af06262
Kyoto	101278 aba 106381 a1 px1 or1
VDRC	v16826 w1118 P{GD1369}v16826
	More stocks available...
Genomic Clones ( 1 )
	BACR02O12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH21134
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	7687 52204 79018 109321 119670 144683 214563.7 273204 bs68h02 CK01.169C.D7 EC30552 EK103916 EK164038 EK239637 EP03205 EP16545 FGM219E12 IP05207
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000008 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43852
Antibody Information
	polyclonal (Liu and Lengyel, 2000)
Other Information
Discoverer
	Bridges, 24th May 1912.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: a CG6741 (Lengyel, 2000.3.26) Source for merge of: a CG13505 (Millburn, 2000.5.31) Source for merge of: a CG13505 CG6741 (Lengyel, 2000.8.1)
Additional comments
Other Comments
	a may affect eye development by modulating adherens junctions of the developing ommatidia. (Liu and Lengyel, 2000) Defined by recessive mutations that result in a broad, often bent, wing. (Lindsley and Grell, 1968)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079902 NM_166514 NM_001014543 RefSeq (Proteins) • NP_524641 NP_726168 NP_001014543 DDBJ / EMBL / GenBank • AAF37816 AAF37817 AAF37818 AAF46809 AAF46809.2 AAF46810 AAF46810.2 AAL13662 AAX52678 AF188473 AF188474 AF188475 AI389852 AW940815 AY058433 CZ466616 CZ466617 CZ467660 CZ467661 CZ488936 CZ488937 Entrez Gene - A searchable database of RefSeq genes. • 43852 UniProtKB/TrEMBL • Q9W283
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PDZ/DHR/GLGF (IPR001478) GEO • FBgn0000008
Linkouts
	BioGRID - A database of protein and genetic interactions • 68671 DroID - A comprehensive database of gene and protein interactions. • FBgn0000008 DRSC - Results from RNAi screens. • FBgn0000008 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000008 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6741-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000008 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43852 InParanoid A subset of ortholog calls from InParanoid. • AAEL004673-PA Aedes aegypti (mosquito) AGAP010808-PA Anopheles gambiae (mosquito) XP_392250.2 Apis mellifera (honey bee) BGIBMGA003506-PA Bombyx mori (silk worm) CN10325 Caenorhabditis brenneri (small nematode) ENSCAFP00000027923 Canis familiaris (dog) CPIJ017916 Culex pipens (mosquito) 162134 Hypsipyla robusta (cedar shoot borer) 25404 Monocosta brevicollis (choanoflagellate) ENSMODP00000025545 Monodelphis domestica (gray opossum) XP_001604752.1 Nasonia vitripennis (wasp) PHUM007643-PA Pediculus humanus (human body louse) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/arc1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43852 modMine - Data generated by the modENCODE project. • FBgn0000008 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19238 NV10565 LH11947 FBgn0231782 FBgn0221636 FBgn0208971 FBgn0170804 JGI_V11_309940 FBgn0079820 FBgn0149391 FBgn0141564 FBgn0128019 FBgn0114341 FBgn0088690 CPIJ019766 CPIJ017917 CPIJ017916 ACYPI003804 GB10518 AGAP010808 AAEL004673 PHUM044040 GLEAN_01616
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	a (Khokhar et al., 2008, Markstein et al., 2008, Firth and Baker, 2007, Aerts et al., 2010, Wasbrough et al., 2010) Arc (Mueller and Bossinger, 2003, Liu and Lengyel, 1997) bran (Goldschmidt, 1944, ) CG6741 (Lengyel, 2000.8.1, Lengyel, 2000.3.26, Aerts et al., 2010) CG13505 (Khokhar et al., 2008, Lengyel, 2000.8.1, Millburn, 2000.5.31, )
Name Synonym	arc (Khokhar et al., 2008, Liu et al., 1998, Liu and Lengyel, 1997, Firth and Baker, 2007) broad angular (Goldschmidt, 1944, )
Secondary FlyBase IDs
	FBgn0034701 FBgn0034702
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Book  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Aerts et al., 2010, PLoS Biol. 8(7): e1000435 Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification. [FBrf0211419] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...