General Information
Symbol
Dmel\Abd-B
Species
D. melanogaster
Name
Abdominal B
Annotation Symbol
CG11648
Feature Type
FlyBase ID
FBgn0000015
Gene Model Status
Stock Availability
Gene Snapshot
Abdominal B is one of the 3 hox genes of the bithorax complex, specifying the identity of the posterior abdominal segments, the external genitalia and the gonads. It is also involved in regulating the post-mating-response. [Date last reviewed: 2016-09-01]
Also Known As
AbdB, Mcp, iab-7, Fab-7, iab-6
Genomic Location
Cytogenetic map
Sequence location
3R:16,927,212..16,972,236 [-]
Recombination map
3-59
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Protein Family (UniProt, Sequence Similarities)
Belongs to the Abd-B homeobox family. (P09087)
Summaries
Gene Group Membership
BITHORAX COMPLEX -
The bithorax complex (BX-C) is one of two Hox gene complexes. Hox genes encode homeodomain transcription factors. The BX-C controls the identity of the segments that contribute to the posterior thorax and each abdominal segment of the fly. (Adapted from FBrf0190304).
HOX-LIKE HOMEOBOX TRANSCRIPTION FACTORS -
HOX-like (HOXL) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. They encompass transcription factors encoded by the Hox genes of the Antennapedia and the Bithorax gene complexes and genes closely related in sequence. HOXL transcription factors are major regulators of animal development. (Adapted from FBrf0232555).
UniProt Contributed Function Data
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
(UniProt, P09087)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Abd-B: Abdominal-B (I. Duncan and S. Celniker)
Heterozygotes for null alleles show weak anteriorly-directed transformations of A5, A6, and A7. In the male, this results in the presence of a tiny extra tergite in A7 and a loss of pigmentation on the A5 tergite. Heterozygotes are partially to completely sterile in both sexes, but are fertile if a duplication for the BXC [such as Dp(3;5)P5 or Dp(3;1)P68] is present. Hemizygotes and homozygotes are lethal; embryos lack posterior spiracles and filzkorper, have the ventral setal bands of A6, A7 and A8 transformed toward A5 or A4, and develop rudimentary chitinized plates in posterior A8.
iab5: infra-abdominal 5 (I. Duncan)
Hemizygotes show strong transformation of A5 toward A4, resulting in a loss of black pigment in the A5 tergite of the male. In addition, A6 may be weakly transformed toward A4. When homozygous, iab5301 causes a weak transformation of A3 toward A4 as well as a transformation of A5 to A4.
iab6: infra-abdominal 6 (I. Duncan)
Hemizygotes show strong transformations of both A5 and A6 toward A4. Males show a loss of pigment on the A5 and A6 tergites and show the development of bristles on the A6 sternite. Some alleles cause weak transformations of A4 toward A5.
iab7: infra-abdominal 7 (I. Duncan)
Hemizygotes show strong transformations of A5, A6, and A7 toward A4. In males, the A5 and A6 tergites show a loss of pigmentation and an unpigmented A4-type tergite develops in A7. Both A6 and A7 show the development of sternites with bristles. Heterozygotes show a small A7 tergite in the male. Two gain-of-function alleles recorded. iab7Spth (split thorax) heterozygotes display a longitudinal furrow in the mesothorax; iab7SGA heterozygotes causes abdominal structures to develop in the back of the head (Awad, Gausz, Gyurkovics, and Parducz, 1981, Acta Biol. Acad. Sci. Hung. 32: 219-28; Kuhn and Packert, 1988, Dev. Biol. 125: 8-18).
iab8: infra-abdominal 8 (I. Duncan and S. Celniker)
Hemizygous adult males show strong transformation of A5, A6, A7 toward A4. In addition, an A8 tergite develops which is half the size of a normal tergite. In these males, A5 and A6 tergites show a loss of pigmentation and an unpigmented A4-type tergite develops in A7. A6, A7, and A8 all development sternites, the first two with bristles.
iab9: infra-abdominal 9 (I. Duncan and S. Celniker)
Adult homozygotes or hemizygotes show absent or defective genitalia and analia in both sexes. Adults homozygous or heterozygous for iab965 show in addition a partial transformation of A6 toward A7. Embryos hemizygous for iab9 mutations show the development of a zone of naked cuticle and a rudimentary ninth abdominal setal belt posterior to the eighth abdominal setal belt. Posterior spiracles are absent in iab965 and iab948 hemizygotes and are defective in iab9Uab1, iab9tuh-3, and iab9Tab hemizygotes. iab965 and iab948, but not the other iab9 mutations, cause transformations of the A8 setal belt (located in anterior A8) toward A7.
Mcp: Miscadastral pigmentation (E.B. Lewis)
Mcp homozygotes have the fourth (A4) and fifth (A5) abdominal segments transformed to a state intermediate between A5 and A6. Similar, but weaker, tranformations occur in Mcp/+ heterozygotes. Mcp1 can be scored in males by dark pigmentation of the A4 tergite and in females by an effect on the orientation of the lateral bristles of the A4 tergite.
Sab: Superabdominal (E.B. Lewis)
Sab/+ adults show patchy transformations of A3 and A4 to A5. Homozygote viable and more extreme than heterozygote. Mcp1 Sab1 homozygotes show transformations of A3, A4, and A5 to a state intermediate between A5 and A6.
Tab: Transabdominal (E.B. Lewis)
Heterozygous adults have a pair of laterally disposed longitudinal stripes of tissue on the second thoracic segment (T2) probably corresponding to tissue from the dorsal sixth (A6) and/or seventh (A7) abdominal segments. These ectopic stripes of tissue are entirely black in males but only partially pigmented in females. Tab/+ flies are virtually sterile, and have a thin seventh tergite in males. Fertility is partially restored in the presence of a duplication for BXC, such as Dp(3;1)P68. When hemizygous, Tab embryos have a reduction of the posterior spiracles and filzkorper, and a tiny ninth abdominal ventral setal belt that appears as a small row of denticles posterior to the A8 setal belt.
Mc: Microcephalus
Eyes of heterozygote small or absent. Scutellars curve upward. Viability and fertility good. Homozygote usually more extreme than heterozygote but not reliably distinguishable. ale Mc homozygotes completely eyeless; fertile except when crossed to each other (Golubovsky and Zakarov, 1972, DIS 49: 112). Viability of homozygote varies from 100 down to 40%. RK1A.
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\Abd-B or the JBrowse view of Dmel\Abd-B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 6.02
Double stop-codon suppression (UGA, UAG) postulated; FBrf0216884.
Gene model reviewed during 5.44
gene_with_stop_codon_read_through ; SO:0000697
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 6.04
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0083382
3078
270
FBtr0083384
4415
493
FBtr0083381
3251
270
FBtr0083383
3260
270
FBtr0083385
3701
270
FBtr0330709
3260
323
FBtr0346764
3260
286
FBtr0415463
4870
493
FBtr0415464
3715
270
FBtr0415465
8184
270
Additional Transcript Data and Comments
Reported size (kB)
7.8, 4.7, 4.3, 3.7, 3.3 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0082824
30.3
270
10.04
FBpp0082826
55.1
493
9.54
FBpp0082823
30.3
270
10.04
FBpp0082825
30.3
270
10.04
FBpp0089276
30.3
270
10.04
FBpp0303552
35.8
323
9.65
FBpp0312359
31.9
286
9.92
FBpp0373669
55.1
493
9.54
FBpp0373670
30.3
270
10.04
FBpp0373671
30.3
270
10.04
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

493 aa isoforms: Abd-B-PB, Abd-B-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
55, 30 (kD)
491 (aa); 54, 36 (kD)
Comments
The ABD-BI protein corresponds to ABD-BII with a large N-terminal extension; the two proteins contain the same homeodomain. There are two strong transcriptional activation domains in the common part of the two proteins. The ABD-BI-specific exon contains additional transcriptional activation potential, although it is a weaker transcriptional activator than the ABD-BII, apparently due to inhibitory sequences in the ABD-BI-specific exon.
ABD-BI corresponds to ABD-BII with a large N-terminal extension; the two proteins contain the same homeodomain. There are two strong transcriptional activation domains in the common part of the two proteins. The ABD-BI-specific exon contains additional transcriptional activation potential, although it is a weaker transcriptional activator than the ABD-BII, apparently due to inhibitory sequences in the ABD-BI-specific exon.
Antibodies that recognize both the 272aa and 493aa Abd-B proteins were made as well as an antibody specific to the 493aa form of the protein.
Antibodies that recognize both the 272aa and 493aa Abd-B proteins were made.
The antibody reported in this paper recognizes both the Abd-B-m and Abd-B-r proteins.
The expression pattern is a composite pattern for the ABD-BI and ABD-BII proteins. The Abd-B protein homeodomain is no more than 55% identical to any other Drosophila homeodomain.
The expression pattern is a composite pattern for the ABD-BI and ABD-BII proteins.
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Abd-B using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (37 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (33 terms)
Terms Based on Experimental Evidence (22 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (13 terms)
CV Term
Evidence
References
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 4-10 hr AEL

in situ
Stage
Tissue/Position (including subcellular localization)
Reference
larval abdominal segment 8 of female genital disc

Comment: pattern is specific to transcript Abd-B-RB

larval abdominal segment 8 of male genital disc

Comment: pattern is specific to transcript Abd-B-RB

larval abdominal segment 9 of female genital disc

Comment: pattern is specific to transcripts Abd-B-RA, Abd-B-RC, Abd-B-RD, Abd-B-RE

larval abdominal segment 9 of male genital disc

Comment: pattern is specific to transcripts Abd-B-RA, Abd-B-RC, Abd-B-RD, Abd-B-RE

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: reference states 4-7 hr AEL

Comment: reference states 10-13 hr AEL

Additional Descriptive Data
Abd-B-RB transcript (coding for Abd-B m protein isoform) is expressed in segment 8 of the male and female genital discs. Abd-B-RA, Abd-B-RC, Abd-B-RD, and Abd-B-RE transcripts (coding for Abd-B r protein isoform) are expressed in segment 9 of male and female genital discs.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Expressed in somatic gonadal precursors but not in ensheathing cells in stage 17 embryos.
Abd-B protein is detected in embryonic nuclear extracts.
The Abd-B protein is expressed in a subset of the nuclei of larval fat body cells with an anterior boundary of A4 and a posterior limit of A8. Specific labeling of polytene chromosome bands by Abd-B antisera can be mapped from nuclei accumulating this protein.
Protein is detected in the posterior most section of the embryonic dorsal vessel in 3 pairs of cardioblasts.
Abd-B expression is limited to the four posterior-most cardioblasts in segment A8 and two pairs of svp-expression cells in A7.
Abd-B protein is expressed in SL-2 cells.
The level of protein is highest in parasegment 13 at stage 12 and is high in parasegments 11-13 at later stages.
The Abd-B protein is first detected in stage 10 embryos in the anterior region of parasegment 15, parasegment 14 and the posterior region of parasegment 13. By stage 11, the anterior boundary of Abd-B expression is expanded into parasegment 11, and expression is detected mainly in the visceral mesoderm of parasegments 11-13. By stage 13 of embryogenesis, the anterior boarder of expression is extended into parasegment 10 of the ectoderm.
Abd-B protein is expressed in the embryo starting in stage 8. It is detected in the ectoderm and mesoderm of parasegments 13-15 and in the mesoderm of parasegments 11 and 12. It is strongly expressed in the CNS at germband retraction. CNS staining is strongest in parasegment 14 and diminishes in parasegments 12 and 13. It is also expressed in Malpighian tubules, in the visceral mesoderm, in cells surrounding the posterior spiracles, and in the proctodeal primordium. In Pc embryos, Abd-B protein can be detected in the ectoderm and neuromeres of all segments. No labeling is observed in Abd-B-@ embryos.
Abd-B protein is expressed in the embryo starting in stage 8. It is detected in the ectoderm and mesoderm of parasegments 13-15 and in the mesoderm of parasegments 11 and 12. It is strongly expressed in the CNS at germband retraction. CNS staining is strongest in parasegment 14 and diminishes in parasegments 12 and 13. It is also expressed in Malpighian tubules, in visceral mesoderm, in cells surrounding the posterior spiracles, and in the proctodeal primordium. In Pc embryos, Abd-B protein can be detected in the ectoderm and neuromeres of all segments.
Abd-B protein is first detected at germ band retraction stage in the midgut and hindgut visceral mesoderm and the ectoderm of parasegments 11-15.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Abd-B in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 208 )
For All Classical and Insertion Alleles Show
 
Allele of Abd-B
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
      0
      --
        0
        --
        Other relevant insertions
        Transgenic Constructs ( 27 )
        For All Alleles Carried on Transgenic Constructs Show
        Transgenic constructs containing/affecting coding region of Abd-B
        Allele of Abd-B
        Mutagen
        Associated Transgenic Construct
        Stocks
        Transgenic constructs containing regulatory region of Abd-B
        characterization construct
        GAL4 construct
        Deletions and Duplications ( 55 )
        Partially duplicated in
        Disrupted in
        Not duplicated in
        Summary of Phenotypes
        For more details about a specific phenotype click on the relevant allele symbol.
        Lethality
        Allele
        Sterility
        Allele
        Other Phenotypes
        Allele
        Phenotype manifest in
        Allele
        abdominal tergite 5 & trichome (with Df(3R)Abd-BS10)
        adult cuticle & abdominal segment 3 | male
        adult cuticle & abdominal segment 4 | male
        embryonic peripheral nervous system & embryonic abdominal segment 8
        scutum & macrochaeta, with Scer\GAL4C-765
        Orthologs
        Human Orthologs (via DIOPT v7.1)
        Homo sapiens (Human) (31)
        Species\Gene Symbol
        Score
        Best Score
        Best Reverse Score
        Alignment
        Complementation?
        Transgene?
        4 of 15
        Yes
        Yes
        4 of 15
        Yes
        Yes
        3 of 15
        No
        Yes
        3 of 15
        No
        Yes
        3 of 15
        No
        Yes
        3 of 15
        No
        Yes
        3 of 15
        No
        Yes
        2 of 15
        No
        Yes
         
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
         
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
         
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
         
        1 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        Model Organism Orthologs (via DIOPT v7.1)
        Mus musculus (laboratory mouse) (30)
        Species\Gene Symbol
        Score
        Best Score
        Best Reverse Score
        Alignment
        Complementation?
        Transgene?
        4 of 15
        Yes
        Yes
        3 of 15
        No
        Yes
        3 of 15
        No
        Yes
        3 of 15
        No
        Yes
        3 of 15
        No
        Yes
        3 of 15
        No
        Yes
        3 of 15
        No
        Yes
         
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
         
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
         
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
         
        1 of 15
        No
        No
         
        1 of 15
        No
        No
         
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        Rattus norvegicus (Norway rat) (25)
        3 of 13
        Yes
        Yes
        3 of 13
        Yes
        Yes
        3 of 13
        Yes
        Yes
        2 of 13
        No
        Yes
        2 of 13
        No
        Yes
        2 of 13
        No
        Yes
        2 of 13
        No
        Yes
        2 of 13
        No
        Yes
        2 of 13
        No
        Yes
        2 of 13
        No
        Yes
        2 of 13
        No
        Yes
        1 of 13
        No
        No
        1 of 13
        No
        No
        1 of 13
        No
        Yes
        1 of 13
        No
        No
        1 of 13
        No
        No
        1 of 13
        No
        Yes
        1 of 13
        No
        No
        1 of 13
        No
        No
        1 of 13
        No
        Yes
        1 of 13
        No
        No
        1 of 13
        No
        Yes
        1 of 13
        No
        Yes
        1 of 13
        No
        Yes
        1 of 13
        No
        Yes
        Xenopus tropicalis (Western clawed frog) (15)
        3 of 12
        Yes
        Yes
        2 of 12
        No
        Yes
        2 of 12
        No
        Yes
        2 of 12
        No
        Yes
        2 of 12
        No
        Yes
        2 of 12
        No
        Yes
        1 of 12
        No
        No
        1 of 12
        No
        No
        1 of 12
        No
        Yes
        1 of 12
        No
        No
        1 of 12
        No
        Yes
        1 of 12
        No
        Yes
        1 of 12
        No
        Yes
        1 of 12
        No
        Yes
        1 of 12
        No
        No
        Danio rerio (Zebrafish) (37)
        3 of 15
        Yes
        Yes
        3 of 15
        Yes
        Yes
        3 of 15
        Yes
        Yes
        3 of 15
        Yes
        Yes
        3 of 15
        Yes
        Yes
        3 of 15
        Yes
        Yes
        3 of 15
        Yes
        Yes
        3 of 15
        Yes
        Yes
        3 of 15
        Yes
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        2 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        No
        Caenorhabditis elegans (Nematode, roundworm) (4)
        8 of 15
        Yes
        Yes
        3 of 15
        No
        Yes
        1 of 15
        No
        No
        1 of 15
        No
        No
        Arabidopsis thaliana (thale-cress) (1)
        1 of 9
        Yes
        No
        Saccharomyces cerevisiae (Brewer's yeast) (2)
        2 of 15
        Yes
        No
        1 of 15
        No
        Yes
        Schizosaccharomyces pombe (Fission yeast) (0)
        No orthologs reported.
        Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190F6X )
        Organism
        Common Name
        Gene
        AAA Syntenic Ortholog
        Multiple Dmel Genes in this Orthologous Group
        Drosophila melanogaster
        fruit fly
        Drosophila suzukii
        Spotted wing Drosophila
        Drosophila simulans
        Drosophila sechellia
        Drosophila erecta
        Drosophila yakuba
        Drosophila ananassae
        Drosophila pseudoobscura pseudoobscura
        Drosophila persimilis
        Drosophila willistoni
        Drosophila virilis
        Drosophila mojavensis
        Drosophila grimshawi
        Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150EQJ )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Musca domestica
        House fly
        Glossina morsitans
        Tsetse fly
        Lucilia cuprina
        Australian sheep blowfly
        Mayetiola destructor
        Hessian fly
        Mayetiola destructor
        Hessian fly
        Aedes aegypti
        Yellow fever mosquito
        Aedes aegypti
        Yellow fever mosquito
        Anopheles darlingi
        American malaria mosquito
        Anopheles gambiae
        Malaria mosquito
        Culex quinquefasciatus
        Southern house mosquito
        Culex quinquefasciatus
        Southern house mosquito
        Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0I9J )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Bombyx mori
        Silkmoth
        Bombyx mori
        Silkmoth
        Heliconius melpomene
        Postman butterfly
        Apis florea
        Little honeybee
        Apis mellifera
        Western honey bee
        Bombus terrestris
        Buff-tailed bumblebee
        Linepithema humile
        Argentine ant
        Megachile rotundata
        Alfalfa leafcutting bee
        Nasonia vitripennis
        Parasitic wasp
        Dendroctonus ponderosae
        Mountain pine beetle
        Tribolium castaneum
        Red flour beetle
        Pediculus humanus
        Human body louse
        Rhodnius prolixus
        Kissing bug
        Cimex lectularius
        Bed bug
        Cimex lectularius
        Bed bug
        Acyrthosiphon pisum
        Pea aphid
        Zootermopsis nevadensis
        Nevada dampwood termite
        Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ID3 )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Strigamia maritima
        European centipede
        Ixodes scapularis
        Black-legged tick
        Stegodyphus mimosarum
        African social velvet spider
        Tetranychus urticae
        Two-spotted spider mite
        Daphnia pulex
        Water flea
        Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0TNY )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Strongylocentrotus purpuratus
        Purple sea urchin
        Human Disease Model Data
        FlyBase Human Disease Model Reports
          Alleles Reported to Model Human Disease (Disease Ontology)
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          Models ( 0 )
          Allele
          Disease
          Evidence
          References
          Interactions ( 0 )
          Allele
          Disease
          Interaction
          References
          Comments ( 0 )
           
          Human Orthologs (via DIOPT v7.1)
          Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
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          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser

          Please look at the Interaction Group reports for full details of the physical interactions
          protein-protein
          Interacting group
          Assay
          References
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement

          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.