• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Abl

General Information
Symbol	Dmel\Abl	Species	D. melanogaster
Name	Abl tyrosine kinase	Annotation symbol	CG4032
Feature type	protein_coding_gene	FlyBase ID	FBgn0000017
Gene Model Status	Current	Stock availability	24 publicly available
Also Known As	DAbl, D-abl, DROTKABL3
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	73B1-73B4	Sequence location	3L:16,615,461..16,641,674 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Abl tyrosine kinase is referred to in FlyBase by the symbol Dmel\Abl (CG4032, FBgn0000017). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein tyrosine kinase activity; protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of synaptic growth at neuromuscular junction; regulation of cell shape; central nervous system development; peptidyl-tyrosine phosphorylation; ventral furrow formation; dorsal closure; regulation of protein stability; cytoplasmic transport, nurse cell to oocyte; axon guidance; regulation of protein localization. 46 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; multi-cell-component structure; commissure; external compound sense organ; presumptive embryonic/larval nervous system; peripheral nervous system; nervous system; extended germ band embryo; synaptic neuropil subdomain; embryonic/larval neuron; female germline cyst; antennal segment; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: F-actin binding; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SH2 motif; Serine-threonine/tyrosine-protein kinase; Src homology-3 domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1640419_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Abl. Gene sequence location is 3L:16615461..16641674.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Abl: Cellular abl oncogene sequence Considered to be the Drosophila sequence homologous to mammalian c-abl based both on its origin and amino acid sequence as inferred from its nucleotide sequence. ABL protein detected at the time of germ-band shortening in the axons of the central nervous system in a bilateral symmetrical series of points that correspond to the positions of neuromeres; later, protein appears in the axons growing across the midline, but not in the cell bodies of the CNS nor in the PNS. As development proceeds, staining of the longitudinal fascicles and to a lesser extent the commissural fascicles becomes intense; staining also seen in association with axonal outgrowth of neural cells in the eye imaginal disk (Bennett and Hoffmann). Recessive alleles in combination with Df(3L)st-j7 = Df(3L)73A1-2;73B1-2 either die as late pupae or pharate adults with complete cuticle and roughened eyes, Abll1, or as short lived (5-6 days), rough-eyed adults, Abll2 and Abll3. Surviving females lay few eggs, some of which develop into adults; surviving males have motile sperm, but do not mate and produce no progeny. The rough eye is a reflection of some loss of photoreceptor cells plus ommatidial fusion. In combination with a deficiency extending further to the left, e.g., Df(3L)std11 = Df(3L)73A11-B1;73D1-2 to include the locus of Dab, Abll/Abl- genotypes die as late embryos or early first-instar larvae with disrupted axonal organization in the ventral nerve cord (Henkemeyer, Gertler, Goodman, and Hoffmann, Cell 51: 821-28). CNS of doubly deficient embryos, i.e., Abl- Dab-, fails to form commissures and is defective in axonal outgrowth, although the PNS develops normally.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	Sequence features HFA09661 BKN22375 BKN50026 BKN50317 References Lowery et al., 2010, Genetics 185(4): 1311--1325
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 73B1-73B4   Limits computationally determined from genome sequence between P{lacW}l(3)j10E8j10E8&P{PZ}l(3)1053210532 and P{PZ}Baldspot02281
Experimentally Determined Cytological Location
Cytogenetic map Notes References 73B1-73B2   (determined by in situ hybridisation)   (Spradling et al., 1999) 73B1-73B2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999) 73B-73B   (determined by in situ hybridisation)   (Telford et al., 1985)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)	st (Henkemeyer et al., 1987)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Abl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Abl-RA FBtr0075357  NM_080104   6707   1620 Abl-RB FBtr0112790  NM_001104153   6761   1638
Additional Transcript Data & Comments
Reported size (kB)	6.0, 5.5-6.0 (northern blot) (Kimchie et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Abl-PA   FBpp0075116   171.6   1620   7.83     NP_524843   AAF49431 Abl-PB   FBpp0111702   173.6   1638   8.10     NP_001097623   ABW08554
Additional Polypeptide Data & Comments
Reported size (kDa)	180 (kD) (Henkemeyer et al., 1990)
Comments	ena protein is a substrate for Abl tyrosine kinase. (Gertler et al., 1995) Studies of mutated Abl proteins reveal that sequences in the carboxy terminus mediate axonal localization. Disruption of proper subcellular localization correlates with lack of Abl biological function. A novel kinase-independent function of the Abl protein has been identified. (Henkemeyer et al., 1990)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) SH2 motif (IPR000980) Src homology-3 domain (IPR001452) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) F-actin binding (IPR015015) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201616   AA202859   AA940880   AE014296 AAF49431   AE014296 ABW08554   AI113570   AI518280   AI532695   AI533233   AI542114   AI543823   AQ025279   AQ026201   AW941522   AY058497 AAL13726   BE975309   BG638955   BG641297   BI639071   BP540546   CL943582   CO188902   CO188950   CO191002   CO276863   CO281659   CO283610   CO293174   CO311299   CO313832   CO343123   CZ469757   CZ469794   CZ473864   CZ481307   CZ484252   CZ485935   EC051977   EC053296   EC053408   EC054535   EC054981   EC055038   EC056243   EC069565   EC080732   EC202775   EC209182   EC213853   EC221692   EC225689   EC233780   EC243607   EC245337   EV586139   K01042 AAA28443   M19690 AAA28934   M19691 AAA28934   M19692 AAA28934   X06691
UniProtKB/Swiss-Prot	P00522
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
dot blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Wadsworth et al., 1985) prepupal stage -- pupal stage     (Wadsworth et al., 1985) adult stage | female     (Wadsworth et al., 1985) oogenesis & adult stage | female   ovary   (Wadsworth et al., 1985) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage & oogenesis   oocyte   (Kimchie et al., 1989)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Henkemeyer et al., 1990) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   imaginal disc   (Grevengoed et al., 2001) presumptive embryonic/larval central nervous system   (Grevengoed et al., 2001) adepithelial cell   (Grevengoed et al., 2001) neuron   • axon (Grevengoed et al., 2001) embryonic stage | late   epithelial cell   • cytoplasm (Grevengoed et al., 2001) embryonic stage | early   epithelial cell | apical   • cytoplasm (Grevengoed et al., 2001)
Additional Descriptive Data
	Abl protein isexpressed in the axons of the embryonic CNS. It is also expressed in epithelial cells, with enrichment in the apical cortical cytoplasm during cellularization and early gastrulation. Expression is also observed in the epithelial cells of the imaginal discs. (Grevengoed et al., 2001)
Marker for
Subcellular Localization
CV Term	axon (Henkemeyer et al., 1990)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000017    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000017 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000017 expression level Developmental Stage   Expression Level embryo 00-02hr    3331 embryo 02-04hr    3289 embryo 04-06hr    1017 embryo 06-08hr    1621 embryo 08-10hr    2140 embryo 10-12hr    2423 embryo 12-14hr    2320 embryo 14-16hr    2571 embryo 16-18hr    1686 embryo 18-20hr    1157 embryo 20-22hr    2102 embryo 22-24hr    1641 larva L1    566 larva L2    442 larva L3 12hr old    316 larva L3 puffstage 1-2    366 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1217 white prepupae new    1340 white prepupae 12hr    1606 white prepupae 24hr    2289 pupae 2d postWPP    2126 pupae 3d postWPP    838 pupae 4d postWPP    632 adult male 01day    671 adult male 05day    806 adult male 30day    762 adult female 01day    1290 adult female 05day    2001 adult female 30day    2132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3331) embryo 02-04hr  (3289) embryo 04-06hr  (1017) embryo 06-08hr  (1621) embryo 08-10hr  (2140) embryo 10-12hr  (2423) embryo 12-14hr  (2320) embryo 14-16hr  (2571) embryo 16-18hr  (1686) embryo 18-20hr  (1157) embryo 20-22hr  (2102) embryo 22-24hr  (1641) larva L1  (566) larva L2  (442) larva L3 12hr old  (316) larva L3 puffstage 1-2  (366) larva L3 puffstage 3-6  (869) larva L3 puffstage 7-9  (1217) white prepupae new  (1340) white prepupae 12hr  (1606) white prepupae 24hr  (2289) pupae 2d postWPP  (2126) pupae 3d postWPP  (838) pupae 4d postWPP  (632) adult male 01day  (671) adult male 05day  (806) adult male 30day  (762) adult female 01day  (1290) adult female 05day  (2001) adult female 30day  (2132) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3331) embryo 02-04hr  (3289) embryo 04-06hr    1017 embryo 06-08hr  (1621) embryo 08-10hr  (2140) embryo 10-12hr  (2423) embryo 12-14hr  (2320) embryo 14-16hr  (2571) embryo 16-18hr  (1686) embryo 18-20hr    1157 embryo 20-22hr  (2102) embryo 22-24hr  (1641) larva L1    566 larva L2    442 larva L3 12hr old    316 larva L3 puffstage 1-2    366 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1217 white prepupae new    1340 white prepupae 12hr  (1606) white prepupae 24hr  (2289) pupae 2d postWPP  (2126) pupae 3d postWPP    838 pupae 4d postWPP    632 adult male 01day    671 adult male 05day    806 adult male 30day    762 adult female 01day    1290 adult female 05day  (2001) adult female 30day  (2132) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3331 embryo 02-04hr    3289 embryo 04-06hr    1017 embryo 06-08hr    1621 embryo 08-10hr    2140 embryo 10-12hr    2423 embryo 12-14hr    2320 embryo 14-16hr    2571 embryo 16-18hr    1686 embryo 18-20hr    1157 embryo 20-22hr    2102 embryo 22-24hr    1641 larva L1    566 larva L2    442 larva L3 12hr old    316 larva L3 puffstage 1-2    366 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1217 white prepupae new    1340 white prepupae 12hr    1606 white prepupae 24hr    2289 pupae 2d postWPP    2126 pupae 3d postWPP    838 pupae 4d postWPP    632 adult male 01day    671 adult male 05day    806 adult male 30day    762 adult female 01day    1290 adult female 05day    2001 adult female 30day    2132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3331 embryo 02-04hr    3289 embryo 04-06hr    1017 embryo 06-08hr    1621 embryo 08-10hr    2140 embryo 10-12hr    2423 embryo 12-14hr    2320 embryo 14-16hr    2571 embryo 16-18hr    1686 embryo 18-20hr    1157 embryo 20-22hr    2102 embryo 22-24hr    1641 larva L1    566 larva L2    442 larva L3 12hr old    316 larva L3 puffstage 1-2    366 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1217 white prepupae new    1340 white prepupae 12hr    1606 white prepupae 24hr    2289 pupae 2d postWPP    2126 pupae 3d postWPP    838 pupae 4d postWPP    632 adult male 01day    671 adult male 05day    806 adult male 30day    762 adult female 01day    1290 adult female 05day    2001 adult female 30day    2132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000017 expression level Developmental Stage   Expression Level embryo 00-02hr    3331 embryo 02-04hr    3289 embryo 04-06hr    1017 embryo 06-08hr    1621 embryo 08-10hr    2140 embryo 10-12hr    2423 embryo 12-14hr    2320 embryo 14-16hr    2571 embryo 16-18hr    1686 embryo 18-20hr    1157 embryo 20-22hr    2102 embryo 22-24hr    1641 larva L1    566 larva L2    442 larva L3 12hr old    316 larva L3 puffstage 1-2    366 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1217 white prepupae new    1340 white prepupae 12hr    1606 white prepupae 24hr    2289 pupae 2d postWPP    2126 pupae 3d postWPP    838 pupae 4d postWPP    632 adult male 01day    671 adult male 05day    806 adult male 30day    762 adult female 01day    1290 adult female 05day    2001 adult female 30day    2132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3331) embryo 02-04hr  (3289) embryo 04-06hr  (1017) embryo 06-08hr  (1621) embryo 08-10hr  (2140) embryo 10-12hr  (2423) embryo 12-14hr  (2320) embryo 14-16hr  (2571) embryo 16-18hr  (1686) embryo 18-20hr  (1157) embryo 20-22hr  (2102) embryo 22-24hr  (1641) larva L1  (566) larva L2  (442) larva L3 12hr old  (316) larva L3 puffstage 1-2  (366) larva L3 puffstage 3-6  (869) larva L3 puffstage 7-9  (1217) white prepupae new  (1340) white prepupae 12hr  (1606) white prepupae 24hr  (2289) pupae 2d postWPP  (2126) pupae 3d postWPP  (838) pupae 4d postWPP  (632) adult male 01day  (671) adult male 05day  (806) adult male 30day  (762) adult female 01day  (1290) adult female 05day  (2001) adult female 30day  (2132) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3331) embryo 02-04hr  (3289) embryo 04-06hr    1017 embryo 06-08hr  1621 embryo 08-10hr  2140 embryo 10-12hr  2423 embryo 12-14hr  2320 embryo 14-16hr  (2571) embryo 16-18hr  1686 embryo 18-20hr    1157 embryo 20-22hr  2102 embryo 22-24hr  1641 larva L1    566 larva L2    442 larva L3 12hr old    316 larva L3 puffstage 1-2    366 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1217 white prepupae new    1340 white prepupae 12hr  1606 white prepupae 24hr  2289 pupae 2d postWPP  2126 pupae 3d postWPP    838 pupae 4d postWPP    632 adult male 01day    671 adult male 05day    806 adult male 30day    762 adult female 01day    1290 adult female 05day  2001 adult female 30day  2132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3331 embryo 02-04hr    3289 embryo 04-06hr    1017 embryo 06-08hr    1621 embryo 08-10hr    2140 embryo 10-12hr    2423 embryo 12-14hr    2320 embryo 14-16hr    2571 embryo 16-18hr    1686 embryo 18-20hr    1157 embryo 20-22hr    2102 embryo 22-24hr    1641 larva L1    566 larva L2    442 larva L3 12hr old    316 larva L3 puffstage 1-2    366 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1217 white prepupae new    1340 white prepupae 12hr    1606 white prepupae 24hr    2289 pupae 2d postWPP    2126 pupae 3d postWPP    838 pupae 4d postWPP    632 adult male 01day    671 adult male 05day    806 adult male 30day    762 adult female 01day    1290 adult female 05day    2001 adult female 30day    2132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3331 embryo 02-04hr    3289 embryo 04-06hr    1017 embryo 06-08hr    1621 embryo 08-10hr    2140 embryo 10-12hr    2423 embryo 12-14hr    2320 embryo 14-16hr    2571 embryo 16-18hr    1686 embryo 18-20hr    1157 embryo 20-22hr    2102 embryo 22-24hr    1641 larva L1    566 larva L2    442 larva L3 12hr old    316 larva L3 puffstage 1-2    366 larva L3 puffstage 3-6    869 larva L3 puffstage 7-9    1217 white prepupae new    1340 white prepupae 12hr    1606 white prepupae 24hr    2289 pupae 2d postWPP    2126 pupae 3d postWPP    838 pupae 4d postWPP    632 adult male 01day    671 adult male 05day    806 adult male 30day    762 adult female 01day    1290 adult female 05day    2001 adult female 30day    2132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000017    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000017 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000017 expression level Tissue   Expression Level Larval Central Nervous System    23.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.9 Larval Trachea    22.825 Larval Carcass no informative data Adult Head no informative data Adult Eye    23.85 Adult Brain    38 Adult Thoracic-Abdominal Ganglion    28.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    31 Adult Malpighian Tubules no informative data Adult Fat Body    36.4 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    48.9 Adult Testis    38 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    23.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.9 Larval Trachea    22.825 Larval Carcass no informative data Adult Head no informative data Adult Eye    23.85 Adult Brain    38 Adult Thoracic-Abdominal Ganglion    28.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    31 Adult Malpighian Tubules no informative data Adult Fat Body    36.4 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    48.9 Adult Testis    38 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    23.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.9 Larval Trachea    22.825 Larval Carcass no informative data Adult Head no informative data Adult Eye    23.85 Adult Brain    38 Adult Thoracic-Abdominal Ganglion    28.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    31 Adult Malpighian Tubules no informative data Adult Fat Body    36.4 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    48.9 Adult Testis    38 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    23.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.9 Larval Trachea    22.825 Larval Carcass no informative data Adult Head no informative data Adult Eye    23.85 Adult Brain    38 Adult Thoracic-Abdominal Ganglion    28.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    31 Adult Malpighian Tubules no informative data Adult Fat Body    36.4 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    48.9 Adult Testis    38 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000017 expression level Tissue   Expression Level Larval Central Nervous System    23.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.9 Larval Trachea    22.825 Larval Carcass no informative data Adult Head no informative data Adult Eye    23.85 Adult Brain    38 Adult Thoracic-Abdominal Ganglion    28.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    31 Adult Malpighian Tubules no informative data Adult Fat Body    36.4 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    48.9 Adult Testis    38 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    23.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.9 Larval Trachea    22.825 Larval Carcass no informative data Adult Head no informative data Adult Eye    23.85 Adult Brain    38 Adult Thoracic-Abdominal Ganglion    28.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    31 Adult Malpighian Tubules no informative data Adult Fat Body    36.4 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    48.9 Adult Testis    38 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    23.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.9 Larval Trachea    22.825 Larval Carcass no informative data Adult Head no informative data Adult Eye    23.85 Adult Brain    38 Adult Thoracic-Abdominal Ganglion    28.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    31 Adult Malpighian Tubules no informative data Adult Fat Body    36.4 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    48.9 Adult Testis    38 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    23.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    28.9 Larval Trachea    22.825 Larval Carcass no informative data Adult Head no informative data Adult Eye    23.85 Adult Brain    38 Adult Thoracic-Abdominal Ganglion    28.8 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    31 Adult Malpighian Tubules no informative data Adult Fat Body    36.4 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    48.9 Adult Testis    38 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    23.85   NA  Brain    38   23.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    28.8   NA  Crop    no informative data   no informative data  Midgut    no informative data   no informative data  Hindgut    31   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    36.4   28.9  Salivary Gland    no informative data   NA  Heart    no informative data   22.825  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    48.9   NA  Testis    38   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000017 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4032-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Abl1) Abl4 lethal (with Abl4) Abl1 lethal (with Df(3L)st-j7) Abl1 lethal | embryonic stage | recessive | rescuable maternal effect Abl1 Abl4 lethal | pupal stage Abl3 lethal | pupal stage (with Abl1) Abl4 lethal | pupal stage (with Abl4) Abl1 lethal | pupal stage | recessive Abl1 Abl2 lethal | recessive Abl04674 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 AblGD1344 semi-lethal | recessive Abll1 Abll2 Abll3 viable AblEY13532 viable, with Scer\GAL4hs.2sev AblScer\UAS.cFa viable | reduced (with Df(3L)st-j7) Abl1 Abl2 Sterility Allele fertile AblEY13532 fertile, with Scer\GAL4hs.2sev AblScer\UAS.cFa Other Phenotypes Allele cell shape defective, with Scer\GAL4MtnA.PU AblScer\UAS.T:Avic\GFP-EGFP mitotic cell cycle defective | maternal effect Abl4 neuroanatomy defective Abl1 Abl2 Abl4 AbldsRNA.cLa Ablunspecified neuroanatomy defective, with Scer\GAL41407 AblScer\UAS.cFa neuroanatomy defective, with Scer\GAL4elav.PLu AblScer\UAS.cFa neuroanatomy defective, with Scer\GAL4elav-C155 AblScer\UAS.cFa neuroanatomy defective, with Scer\GAL4P2.4.Pdf AblScer\UAS.cFa neuroanatomy defective (with Abl1) Abl4 neuroanatomy defective (with Abl4) Abl1 neuroanatomy defective | embryonic stage (with Abl1) Abl4 neuroanatomy defective | embryonic stage (with Abl2) Abl4 neuroanatomy defective | embryonic stage (with Abl4) Abl1 Abl2 neuroanatomy defective | larval stage (with Abl1) Abl4 neuroanatomy defective | larval stage (with Abl4) Abl1 AblEP3101 neuroanatomy defective | larval stage (with AblEP3101) Abl4 neuroanatomy defective | larval stage (with Df(3L)st-j7) Abl1 Abl4 neuroanatomy defective | recessive Abl4 neurophysiology defective | larval stage (with Abl1) Abl4 neurophysiology defective | larval stage (with Abl4) Abl1 size defective | heat sensitive, with Scer\GAL4GMR.PF AblScer\UAS.cFa visible, with Scer\GAL4GMR.PF AblScer\UAS.cFa visible, with Scer\GAL4hs.2sev AblScer\UAS.cFa visible | recessive Abl4 wild-type Abl+mTnabl Abl+mTnabl-ala Abl+mTnabl-lys Abl+mTnabl-ts Phenotype manifest in Allele actin cytoskeleton | embryonic stage | maternal effect Abl4 actin filament & egg chamber | germ-line clone Abl4 amnioserosa Ablunspecified antennal commissure, with Scer\GAL4SG18.1 AblEP3101 antennal lobe glomerulus, with Scer\GAL4SG18.1 AblEP3101 anterior commissure Abl4 central nervous system Abl2 commissure Abl1 Abl2 AbldsRNA.cLa Ablunspecified commissure (with Abl1) Abl4 commissure (with Abl4) Abl1 dorsal closure embryo Abl4 Ablunspecified egg | germline clone | maternal effect Abl4 embryonic/first instar larval cuticle | dorsal Abl4 embryonic/larval neuromuscular junction (with Abl1) Abl4 embryonic/larval neuromuscular junction (with Abl4) Abl1 embryonic/larval neuron Abl2 Abl4 embryonic/larval neuron, with Scer\GAL4elav.PLu AblScer\UAS.cFa embryonic leading edge cell Ablunspecified extended germ band embryo Abl4 Ablunspecified eye, with Scer\GAL4hs.2sev AblScer\UAS.cFa eye | heat sensitive, with Scer\GAL4GMR.PF AblScer\UAS.cFa eye photoreceptor cell Abl4 follicle cell, with Scer\GAL4hs.PB AblScer\UAS.cFa follicle cell & actin filament | somatic clone Abl4 follicle cell | somatic clone Abl4 interommatidial bristle Abl4 interommatidial bristle, with Scer\GAL4hs.2sev AblScer\UAS.cFa intersegmental nerve Abl1 Abl2 intersegmental nerve, with Scer\GAL41407 AblScer\UAS.cFa intersegmental nerve, with Scer\GAL4elav.PLu AblScer\UAS.cFa intersegmental nerve, with Scer\GAL4elav-C155 AblEP3101 AblScer\UAS.cFa intersegmental nerve, with Scer\GAL4unspecified AblScer\UAS.cFa intersegmental nerve (with Abl1) Abl4 intersegmental nerve (with Abl2) Abl4 intersegmental nerve (with Abl4) Abl1 Abl2 ISNb, with Scer\GAL41407 AblScer\UAS.cFa ISNb (with Abl2) Abl4 ISNb (with Abl4) Abl2 longitudinal connective Abl1 Abl2 Abl4 Ablunspecified longitudinal connective, with Scer\GAL4elav.PLu AblEP3101 AblScer\UAS.cFa longitudinal connective, with Scer\GAL4sca-537.4 AblEP3101 AblScer\UAS.cFa longitudinal connective (with Abl1) Abl4 longitudinal connective (with Abl2) Abl4 longitudinal connective (with Abl4) Abl1 Abl2 AblEP3101 longitudinal connective (with AblEP3101) Abl4 longitudinal connective (with Df(3L)st-j7) Abl4 midline crossing tract Abl1 NMJ bouton | supernumerary (with Abl1) Abl4 NMJ bouton | supernumerary (with Abl4) Abl1 AblEP3101 NMJ bouton | supernumerary (with AblEP3101) Abl4 NMJ bouton | supernumerary (with Df(3L)st-j7) Abl1 ommatidium Abl4 Abll2 Abll3 ommatidium, with Scer\GAL4GMR.PF AblScer\UAS.cFa ommatidium, with Scer\GAL4hs.2sev AblScer\UAS.cFa posterior commissure Abl4 presumptive embryonic/larval central nervous system Abl1 Abl2 Abl4 Ablunspecified retina | heat sensitive, with Scer\GAL4GMR.PF AblScer\UAS.cFa SNa (with Abl2) Abl4 SNa (with Abl4) Abl2 spindle | cleavage stage | maternal effect Abl4 synaptic vesicle & NMJ bouton (with Abl1) Abl4 synaptic vesicle & NMJ bouton (with Abl4) Abl1 ventral adult lateral neuron & axon, with Scer\GAL4P2.4.Pdf AblScer\UAS.cFa ventral furrow | non-rescuable maternal effect Abl4 ventral nerve cord commissure (with Abl1) Abl4 ventral nerve cord commissure (with Abl4) Abl1
Classical Alleles ( 23 )
For All Classical Alleles Show
Allele of Abl Class Mutagen Stocks Known lesion Abl1 hypomorphic allele - genetic evidence 4 Yes Abl4 hypomorphic allele - genetic evidence 3 Yes Abl2 amorphic allele - genetic evidence 1 Yes Abl04674 P-element activity 1 -- Ablc05130 piggyBac transposase 1 -- AblCB-6014-3 1 -- Abld04320 P-element activity 1 -- AblDG03106 1 -- Able03544 piggyBac transposase 1 -- AblEY13532 P-element activity 1 -- Ablf01778 piggyBac transposase 1 -- Ablf03378 piggyBac transposase 1 -- AblMI00347 1 -- Abl3 hypomorphic allele - genetic evidence 0 -- Ablc05213 piggyBac transposase 0 -- AblCPTI000349 piggyBac transposase 0 Yes AblCPTI000658 piggyBac transposase 0 Yes AblEP3101 P-element activity 0 Yes AblEP3566 P-element activity 0 -- Abll1 ethyl methanesulfonate 0 -- Abll2 ethyl methanesulfonate 0 -- Abll3 ethyl methanesulfonate 0 -- Ablunspecified 0 --
Alleles Carried on Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Abl Class Mutagen Stocks Known lesion AblScer\UAS.cFa in vitro construct - regulatory fusion 3 Yes AblGD1344 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AblGL00234 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AblJF02960 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AblK417N.Scer\UAS in vitro construct - regulatory fusion 1 Yes Abl+mTnabl-ala in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Abl+mTnabl-lys in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Abl+mTnabl-ts in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Abl+mTnabl hypomorphic allele - genetic evidence in vitro construct - minigene in vitro construct - genomic fragment 0 Yes Abl+tEa in vitro construct - genomic fragment 0 -- Abl2kb.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AblAct5C.PC in vitro construct - regulatory fusion 0 Yes AblAct5C.PG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes AblAct5C.PW in vitro construct - regulatory fusion 0 Yes AbldsRNA.cFa in vitro construct - RNAi 0 Yes AbldsRNA.cLa in vitro construct - RNAi 0 Yes AbldsRNA.cRa in vitro construct - RNAi 0 Yes AbldsRNA.cWa in vitro construct - RNAi 0 Yes AblK417N.Act5C in vitro construct - amino acid replacement 0 Yes AblKK102309 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes AblMtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AblScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AblW118A.Act5C in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)81k19 (Spradling et al., 1999) Df(3L)st4 (Bedian, 1998.10.2) Df(3L)st7 (Bedian, 1998.10.2) Df(3L)st62 (Bedian, 1998.10.2) Df(3L)st100.62 (McKeown et al., 1987, Gertler et al., 1989, Belote et al., 1990, Hill et al., 1995) Df(3L)st34C (Wills et al., 1999) Df(3L)st-b11 (Bedian, 1998.10.2) Df(3L)st-E34 (Gertler et al., 1989, Belote et al., 1990, Quan et al., 1993) Df(3L)st-E36 (Henkemeyer et al., 1987, Belote et al., 1990, Bennett and Hoffmann, 1992, Garcia-Alonso et al., 1995) Df(3L)st-j7 (Bedian, 1998.10.2, McKeown et al., 1987, Belote et al., 1990, Hill et al., 1995) Df(3L)st-j11 (Bedian, 1998.10.2) Df(3L)tra (McKeown et al., 1987, Belote et al., 1990) In(3L)std11 (McKeown et al., 1987, Gertler et al., 1989, Quan et al., 1993, Hill et al., 1995, Saha and Sinha, 1996)
Not disrupted in	Df(3L)33f1 (Wemmer and Klaembt, 1995) Df(3L)st6 (Bedian, 1998.10.2) Df(3L)st7P (McKeown et al., 1987, Belote et al., 1990) Df(3L)st-a20 (McKeown et al., 1987, Belote et al., 1990) Df(3L)st-e4 (McKeown et al., 1987, Belote et al., 1990) Df(3L)st-E52 (Belote et al., 1990) Df(3L)st-f13 (Bedian, 1998.10.2, McKeown et al., 1987, Belote et al., 1990) Df(3L)st-g24 (McKeown et al., 1987, Belote et al., 1990, Hill et al., 1995) Df(3L)th2 (Bedian, 1998.10.2) Df(3L)thSS102 (Bedian, 1998.10.2) Df(3L)VB-33 (Bedian, 1998.10.2) In(3L)std11 (Belote et al., 1990)
Duplicated in	Dp(3;3)st+g18 (Bennett and Hoffmann, 1992)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1344} NA P{KK102309} NA P{TRiP.GL00234} NA P{TRiP.JF02960} NA P{UAS-Abl.F} NA P{UAS-Abl.K417N} NA characterization construct P{Abl.G} NA P{Abl.Gts} NA P{Abl.G-ala} NA P{Abl.G-lys} NA P{Abl+tEa,Fas1+tEa} NA P{Abl-GFP.2kb} NA P{Tn1a} NA P{Tn1b} NA P{Tnc-ablMFM} NA P{Tnv-abl} NA P{UAS-P185} NA P{UAS-P210} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}AblEP3101 NA P{EP}AblEP3566 NA P{EPgy2}AblEY13532 NA P{XP}Abld04320 NA insertion of enhancer trap P{PZ}Abl04674 No miscellaneous insertions Mi{MIC}AblMI00347 NA P{RS3}AblCB-6014-3 NA P{wHy}AblDG03106 NA PBac{602.P.SVS-1}AblCPTI000349 NA PBac{602.P.SVS-1}AblCPTI000658 NA PBac{PB}Ablc05130 NA PBac{PB}Ablc05213 NA PBac{RB}Able03544 NA PBac{WH}Ablf01778 NA PBac{WH}Ablf03378 NA
Gene Ontology: Function, Process & Cellular Component ( 24 unique terms )
Terms Based on Experimental Evidence ( 18 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Abi (Juang and Hoffmann, 1999) protein tyrosine kinase activity inferred from direct assay (Bashaw et al., 2000) inferred from direct assay AND inferred from sequence or structural similarity (Henkemeyer et al., 1988) inferred from mutant phenotype (Huang et al., 2007)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with Fas1 (Elkins et al., 1990) inferred from genetic interaction with robo AND inferred from mutant phenotype (Bashaw et al., 2000) inferred from mutant phenotype (Liebl et al., 2000, Crowner et al., 2003, Lowery et al., 2010) central nervous system development inferred from genetic interaction with Nrt (Gertler et al., 1989) cytoplasmic transport, nurse cell to oocyte inferred from mutant phenotype (Gates et al., 2009) dorsal closure inferred from mutant phenotype (Grevengoed et al., 2001) negative regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (Lin et al., 2009) peptidyl-tyrosine phosphorylation inferred from mutant phenotype (Huang et al., 2007) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003, Fox and Peifer, 2007) regulation of protein localization inferred from direct assay (Huang et al., 2007) regulation of protein stability inferred from mutant phenotype (Huang et al., 2007) ventral furrow formation inferred from mutant phenotype (Fox and Peifer, 2007)
Cellular Component
CV term Evidence References
apical cortex inferred from direct assay (Fox and Peifer, 2007) cell-cell junction inferred from direct assay (Bennett and Hoffmann, 1992) cytoplasm inferred from direct assay (Bennett and Hoffmann, 1992) cytosol inferred from direct assay (Huang et al., 2007) extrinsic to plasma membrane inferred from direct assay (Bennett and Hoffmann, 1992) muscle tendon junction inferred from direct assay (Bennett and Hoffmann, 1992)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR015015, InterPro:IPR017441 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1986.7.21) non-membrane spanning protein tyrosine kinase activity inferred from electronic annotation with InterPro:IPR015015 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Hanks and Hunter, 1995) protein tyrosine kinase activity non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1986.7.21)
Biological Process
CV term Evidence References
dorsal closure non-traceable author statement (Harden, 2002) morphogenesis of an epithelium non-traceable author statement (Harden, 2002) protein phosphorylation non-traceable author statement (Morrison et al., 2000) regulation of actin polymerization or depolymerization traceable author statement (Martin and Wood, 2002) regulation of cell shape non-traceable author statement (Harden, 2002)
Cellular Component
CV term Evidence References
adherens junction non-traceable author statement (Swiss-Prot Project Members, 1986.7.21) traceable author statement (Harden, 2002) cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1986.7.21)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Abl allele Gene References Abl1 Ama (Liebl et al., 2003) arm (Loureiro and Peifer, 1998) CycE (Brumby et al., 2004) ena (Liebl et al., 2000) Fas1 (Elkins et al., 1990) fax (Hill et al., 1995, Liebl et al., 2000) Lar (Wills et al., 1999, Wills et al., 2002) N (Giniger, 1998, Crowner et al., 2003) Nrt (Gertler et al., 1989, Liebl et al., 2000, Liebl et al., 2003) pros (Gertler et al., 1989) shg (Grevengoed et al., 2001) trio (Liebl et al., 2000) Abl2 capt (Wills et al., 2002) chb (Lee et al., 2004) chic (Wills et al., 1999) Fas1 (Elkins et al., 1990) Lar (Wills et al., 1999, Wills et al., 2002) N (Giniger, 1998) Nrt (Gertler et al., 1989) pros (Gertler et al., 1989) robo (Wills et al., 2002) sli (Wills et al., 2002) Abl4 Ama (Liebl et al., 2003) arm (Loureiro and Peifer, 1998) capt (Wills et al., 2002) chb (Lee et al., 2004) chic (Wills et al., 1999) ena (Liebl et al., 2000, Grevengoed et al., 2001, Wills et al., 2002) fax (Liebl et al., 2000) Lar (Wills et al., 1999) Nrt (Liebl et al., 2000, Liebl et al., 2003) robo (Wills et al., 2002) shg (Grevengoed et al., 2001) trio (Liebl et al., 2000) Abl04674 CycE (Brumby et al., 2004) Abl+mTnabl pros (Gertler et al., 1993) AbldsRNA.cLa Ama (Liebl et al., 2003) Nrt (Liebl et al., 2003) AblEP3101 robo (Bashaw et al., 2000) slbo (Rorth et al., 1998) sli (Bashaw et al., 2000) AblScer\UAS.cFa chb (Lee et al., 2004) lea (Wills et al., 2002) N (Crowner et al., 2003) robo (Wills et al., 2002) robo3 (Wills et al., 2002) Ablunspecified Abl::Abelson\v-Abl (Henkemeyer et al., 1990) capt (Wills et al., 2002) ena (Gertler et al., 1990) unspecified Ama (Liebl et al., 2001) bsk (Leyssen et al., 2005) Dab (Fogerty et al., 1999) fj (Buckles et al., 2001) Fmr1 (Rusch et al., 2002) fra (Forsthoefel et al., 2005) Nrt (Fogerty et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69904 DroID - A comprehensive database of gene and protein interactions. • FBgn0000017 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45821
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10512 Dere\GG15861 Dgri\GH16452 Dmoj\GI16710 Dper\GL12720 Dpse\GA17894 Dsec\GM24379 Dsim\GD12452 Dvir\GJ12453 Dwil\GK20085 Dyak\GE22200
Curated drosophilid orthologs	Dpse\GA17894
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008777-PA Aedes aegypti (mosquito) AGAP004989-PA Anopheles gambiae (mosquito) XP_392652.2 Apis mellifera (honey bee) XP_001949462.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000023920 Bos taurus (bovine) CN19546 Caenorhabditis brenneri (small nematode) CBP36394 Caenorhabditis briggsae (nematode) CE31570 Caenorhabditis elegans (worm) ENSCAFP00000020505 Canis familiaris (dog) JA04680 Caenorhabditis japonica (nematode) CPIJ003985 Culex pipens (mosquito) ENSCPOP00000011885 Cavia porcellus (guinea pig) 168953 Chlamidomonas reinhardtii (green alga) RP46781 Caenorhabditis remanei (nematode) ENSDARP00000057184 Danio rerio (zebra fish) ENSECAP00000012868 Equus caballus (horse) ENSGACP00000022183 Gymnopilus aculeatus (mushroom) ENSGALP00000006154 Gallus gallus (chicken) 166124 Hypsipyla robusta (cedar shoot borer) ENSP00000356595 Homo sapiens (human) ISCW000294-PA Ixodes scapularis (deer tick) LmjF27.1370 Leishmania major (virus) 21810 Monocosta brevicollis (choanoflagellate) ENSMODP00000015185 Monodelphis domestica (gray opossum) ENSMMUP00000037795 Macaca mulatta (rhesus monkey) ENSMUSP00000075167 Mus musculus (house mouse) XP_001602611.1 Nasonia vitripennis (wasp) ENSOANP00000001666 Ornithorynchus anatinus (platypus) ENSORLP00000009305 Oryzias latipes (japanese killifish) PHUM001355-PA Pediculus humanus (human body louse) ENSPPYP00000000533 Pongo pygmaeus (orangutan) ENSPTRP00000051478 Pan troglodytes (chimpanzee) ENSRNOP00000044534 Rattus norvegicus (norway rat) Smp_128790 Schistosoma mansoni (trematode parasite) XP_968668.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018565 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014748 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000027417 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18744 NV17221 LH10586 ISCW000295 FBgn0239427 FBgn0222082 FBgn0199695 FBgn0184183 FBgn0179243 JGI_V11_5206 FBgn0077903 FBgn0150326 FBgn0139458 FBgn0123923 FBgn0108099 FBgn0087553 CPIJ003985 CPIJ009602 BGIBMGA002070 BGIBMGA002069 ACYPI007038 GB11301 AGAP004989 AAEL008777 PHUM538010 GLEAN_02481
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Bloomington	28993 w*; P{UAS-Abl.F}2 8565 Abl2/TM6B, Tb1 28325 y1 v1; P{TRiP.JF02960}attP2 8596 w*; wgSp-1/CyO; P{UAS-Abl.F}3 8567 w*; P{UAS-Abl.F}2/CyO; TM2/TM6B, Tb1
Harvard	- P{XP}Abld04320 - PBac{PB}Ablc05130 - PBac{RB}Able03544 - PBac{WH}Ablf01778 - PBac{WH}Ablf03378
Kyoto	123881 w1118; P{RS3}AblCB-6014-3
VDRC	v2897 w1118 P{GD1344}v2897
	More stocks available...
Genomic Clones ( 1 )
	BACR11G05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD03455
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH09917 LD04711 LD23190 LD37750 SD04284 SD04984 SD08201 SD12616 SD21518
Other clones	1554 7429 31870 39713 43250 105144 107571 108081 bs41c02 CK01.52B.C2 CK01.62C.C4 Dmel_dig_014302_0592_2064 EC051977 EC053296 EC053408 EC054535 EC054981 EC055038 EC056243 EK042341 EK042528 EK050442 EK122244 EK157855 EK163752 EK202005 EK224109 EK234155 EP16140 FGA005E04 LD39618
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000017 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45821
Antibody Information
	polyclonal (Grevengoed et al., 2001, Song et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Abl CG4032 (Bayraktaroglu, 2000.4.13) Source for merge of: Abl l(3)04674 (Spradling et al., 1999)
Additional comments
Other Comments
	The N/Abl interaction may promote the turning of ISNb axons by attenuating Abl-dependant adhesion of ISNb axons to their substratum, thus releasing the axons to respond to attraction from target muscles. (Crowner et al., 2003) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become retracted (unspread but flat). Kc167 cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Abl antagonizes robo signalling in the central nervous system. (Bashaw et al., 2000) trio and Abl cooperate in regulating axon outgrowth in the embryonic central nervous system. (Liebl et al., 2000) Abl functions in the intersegmental nerve b motor choice point pathway as an antagonist of Lar. (Wills et al., 1999) ena protein is directly phosphorylated by Abl protein. (Comer et al., 1998) The Dab and Abl gene products may play a role in N signalling in axons, perhaps by binding to the N intracellular domain. (Giniger, 1998) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) Severe defects in CNS axonogenesis are seen in double mutants with mfas. (Hu et al., 1998) Phylogenetic analysis of the PTK family. (Suga et al., 1997) l(2)gl encodes a cytoskeletal protein that is required in aspects of Abl-dependent axonogenesis. (Saha and Sinha, 1996) A critical function of Abl is to phosphorylate and negatively regulate ena protein during neural development. (Gertler et al., 1995) fax encodes a novel protein that is not necessary for viability in an otherwise wild type genetic background. A requirement for fax is observed upon reduction or loss of Abl or Nrt. (Hill et al., 1995) Abl gene product may play a role in establishing and maintaining cell-cell interactions. (Bennett and Hoffmann, 1992) Abl mutants show phenotypes in somatic muscles and eye imaginal disks. (Bennett and Hoffmann, 1992) Abl shows a non-additive phenotype in combination with Fas1TE89Da. Fas1 plays an important role in growth cone guidance, as seen in an Abl mutant background. (Elkins et al., 1990) In vitro modified Abl constructs are used to investigate the Abl function in axonal localization. Fusion proteins with analogous regions of the human, murine or viral abl genes were expressed and tested for their ability to provide function for Abl mutants that would normally die as pupae. (Henkemeyer et al., 1990) Drosophila Abl and murine v-abl chimeric protein was constructed to assess functional conservation. Results imply that the transforming function of Abl tyrosine protein kinases are only partially conserved through evolution. (Holland et al., 1990) Structural and biochemical evidence suggest the gene encodes a protein tyrosine kinase. (Wadsworth, 1990) The Abl gene product participates in the process of forming and/or maintaining axonal connections in the nervous system. (Gertler et al., 1989) The transcription pattern of Abl was analyzed in neuroblasts derived from tumorous larval brain of l(2)gl larvae and S2 tissue culture cells. Abl expresses constitutive as well as maternal/embryonic-specific transcripts. (Kimchie et al., 1989) The Abl gene promoter has been isolated and sequenced. (Segev et al., 1988) The highest level of transcript hybridization for Abl, Btk29A and Src64B was found during embryogenesis and metamorphosis, suggesting that the transcripts are of maternal origin. Adult females carry three to four times the amount of transcript males do, the major site of expression in the females is the ovary. (Wadsworth et al., 1985) Considered to be the Drosophila sequence homologous to mammalian c-abl based both on its origin and amino acid sequence as inferred from its nucleotide sequence. ABL protein detected at the time of germ-band shortening in the axons of the central nervous system in a bilateral symmetrical series of points that correspond to the positions of neuromeres; later, protein appears in the axons growing across the midline, but not in the cell bodies of the CNS nor in the PNS. As development proceeds, staining of the longitudinal fascicles and to a lesser extent the commissural fascicles becomes intense; staining also seen in association with axonal outgrowth of neural cells in the eye imaginal disk (Bennett and Hoffmann). Recessive alleles in combination with Df(3L)st-j7 either die as late pupae or pharate adults with complete cuticle and roughened eyes, Abll1, or as short lived (5-6 days), rough-eyed adults, Abll2 and Abll3. Surviving females lay few eggs, some of which develop into adults; surviving males have motile sperm, but do not mate and produce no progeny. The rough eye is a reflection of some loss of photoreceptor cells plus ommatidial fusion. In combination with a deficiency extending further to the left, e.g., In(3L)std11 to include the locus of Dab, Abll1/Abl- genotypes die as late embryos or early first-instar larvae with disrupted axonal organization in the ventral nerve cord (Henkemeyer, Gertler, Goodman and Hoffmann, 1987). CNS of doubly deficient embryos, i.e., Abl- Dab-, fails to form commissures and is defective in axonal outgrowth, although the PNS develops normally.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080104 NM_001104153 RefSeq (Proteins) • NP_524843 NP_001097623 DDBJ / EMBL / GenBank • AA202859 AAA28443 AAA28934 AAF49431 AAL13726 ABW08554 AI113570 AQ025279 AQ026201 AW941522 AY058497 CL943582 CZ469757 CZ469794 CZ473864 CZ481307 CZ484252 CZ485935 K01042 M19690 M19691 M19692 X06691 Entrez Gene - A searchable database of RefSeq genes. • 45821 UniProtKB/Swiss-Prot • P00522
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) SH2 motif (IPR000980) Src homology-3 domain (IPR001452) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) F-actin binding (IPR015015) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69904 DroID - A comprehensive database of gene and protein interactions. • FBgn0000017 DRSC - Results from RNAi screens. • FBgn0000017 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000017 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4032-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000017 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45821 InParanoid A subset of ortholog calls from InParanoid. • AAEL008777-PA Aedes aegypti (mosquito) AGAP004989-PA Anopheles gambiae (mosquito) XP_392652.2 Apis mellifera (honey bee) XP_001949462.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000023920 Bos taurus (bovine) CN19546 Caenorhabditis brenneri (small nematode) CBP36394 Caenorhabditis briggsae (nematode) CE31570 Caenorhabditis elegans (worm) ENSCAFP00000020505 Canis familiaris (dog) JA04680 Caenorhabditis japonica (nematode) CPIJ003985 Culex pipens (mosquito) ENSCPOP00000011885 Cavia porcellus (guinea pig) 168953 Chlamidomonas reinhardtii (green alga) RP46781 Caenorhabditis remanei (nematode) ENSDARP00000057184 Danio rerio (zebra fish) ENSECAP00000012868 Equus caballus (horse) ENSGACP00000022183 Gymnopilus aculeatus (mushroom) ENSGALP00000006154 Gallus gallus (chicken) 166124 Hypsipyla robusta (cedar shoot borer) ENSP00000356595 Homo sapiens (human) ISCW000294-PA Ixodes scapularis (deer tick) LmjF27.1370 Leishmania major (virus) 21810 Monocosta brevicollis (choanoflagellate) ENSMODP00000015185 Monodelphis domestica (gray opossum) ENSMMUP00000037795 Macaca mulatta (rhesus monkey) ENSMUSP00000075167 Mus musculus (house mouse) XP_001602611.1 Nasonia vitripennis (wasp) ENSOANP00000001666 Ornithorynchus anatinus (platypus) ENSORLP00000009305 Oryzias latipes (japanese killifish) PHUM001355-PA Pediculus humanus (human body louse) ENSPPYP00000000533 Pongo pygmaeus (orangutan) ENSPTRP00000051478 Pan troglodytes (chimpanzee) ENSRNOP00000044534 Rattus norvegicus (norway rat) Smp_128790 Schistosoma mansoni (trematode parasite) XP_968668.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018565 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014748 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000027417 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/abelson1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45821 modMine - Data generated by the modENCODE project. • FBgn0000017 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18744 NV17221 LH10586 ISCW000295 FBgn0239427 FBgn0222082 FBgn0199695 FBgn0184183 FBgn0179243 JGI_V11_5206 FBgn0077903 FBgn0150326 FBgn0139458 FBgn0123923 FBgn0108099 FBgn0087553 CPIJ003985 CPIJ009602 BGIBMGA002070 BGIBMGA002069 ACYPI007038 GB11301 AGAP004989 AAEL008777 PHUM538010 GLEAN_02481
Synonyms & Secondary IDs ( 35 )
Reported As
Symbol Synonym	4674 (Harvie et al., 1998) abl (Talbot and VanBerkum, 2005, Jhaveri et al., 2004, Gates et al., 2004, Fox et al., 2004, Grevengoed et al., 2001, Braga and Harwood, 2001, Baum and Perrimon, 2001, Grevengoed and Peifer, 2003, Grevengoed et al., 2002, Jesse et al., 2002, Jesse et al., 2001, Ramel and Katz, 2001, Katz and Buckles, 2000, Buckles and Katz, 2000, Baum et al., 2000, Van Etten, 1999, Kunes, 1999, Baek, 1999, Wills et al., 1999, Hu and Reichardt, 1999, Le and Simon, 1998, Loureiro and Peifer, 1998, Hu et al., 1998, Buckles et al., 1998, Chien, 1998, Suga et al., 1997, Taft et al., 1997, VanBerkum, 1997, Giniger, 1997, Chien, 1996, Therianos et al., 1995, Giniger, 1995, Kania and Bellen, 1995, Hamilton et al., 1995, Hill et al., 1991, Broadie et al., 1993, Goodman and Doe, 1993, Gertler et al., 1993, Nambu et al., 1993, Segal, 1993, Bennett and Hoffmann, 1992, Hoffmann, 1991, Pawson, 1991, Gertler et al., 1990, Elkins et al., 1990, Gertler et al., 1989, Segev et al., 1988, Fox and Peifer, 2006, Liebl et al., 2007, Hsouna et al., 2003, O'Keefe et al., 2011, Fox and Peifer, 2007, Bhat et al., 2007, Andrews et al., 2008, Dorsten et al., 2007, Pawson et al., 2008, Yu et al., 2009, Gates et al., 2009, Hofmeyer and Treisman, 2009, Al-Anzi and Wyman, 2009, Hsouna and VanBerkum, 2008, Dorsten et al., 2010, Burgio et al., 2008) ABL (Morrison et al., 2000) Abl (Artabazon et al., 2007, Rogers et al., 2003, Huang et al., 2007, Prokopenko and Chia, 2007, Martin et al., 2005, Rogers et al., 2008, Xiong et al., 2008, Prokopenko and Chia, 2008, Song et al., 2008, Stephan et al., 2008, Li et al., 2005, Gates et al., 2007, Corrigall et al., 2007, Stevens et al., 2008, Xiong et al., 2009, Jung et al., 2007, Lin et al., 2007, Lin et al., 2009, Hilger et al., 2009, Gim et al., 2001, Dorsten et al., 2010, Oliva and Sierralta, 2010, Smith and Liebl, 2005, Song et al., 2010, Foley et al., 2010, Kuzina et al., 2011, Lowery et al., 2010) abl1   Abl1   Ableson (Ensslen-Craig and Brady-Kalnay, 2004) AblK (Acebes and Ferrus, 2000) Am ABL (Gibson and Spring, 1998) c-abl (Bedian, 1998.10.2) cAbl (Belote et al., 1990) C-abl   CG4032 (Kraut et al., 2001, Kraut et al., 2001, Morrison et al., 2000, Rogers et al., 2003, Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) D-abl (Reinhard et al., 2001, Grevengoed et al., 2000, Garrity, 1999, Saha and Sinha, 1996, Noll et al., 1993) DAbl (Fogerty et al., 1999, Van Vactor et al., 1998) Dabl (Woods and Bryant, 1993, Wang, 1993, Wadsworth, 1990) dAbl (Huang et al., 2007, Lin et al., 2004) Dash (Dobrovolskaia and Belitsky, 1997, ) D-ash (Pribyl et al., 1988) Ddash/abl (Palmer et al., 1999) DROTKABL3 (Fernando Vazquez et al., 2000, Lopez et al., 1999, Schug et al., 1997) Dsrc7   l(3)73Ba   l(3)04674 (BDGP Project Members, 1994-1999, ) l(3)c-abl (McKeown et al., 1987)
Name Synonym	abelson (Forsthoefel et al., 2003, Loureiro et al., 1997, Seeger, 1994, Johnson et al., 2008) Abelson (Bashaw et al., 2000, Buckles and Katz, 2000, Prokopenko and Chia, 2008, Li et al., 2005, Xiong et al., 2009, Hofmeyer and Treisman, 2009, Dorsten et al., 2010) Abelson cytoplasmic tyrosine kinase (Dorsten et al., 2010) Abelson Kinase (Mahaffey et al., 2006) Abelson kinase (Oliva and Sierralta, 2010) Abelson tyrosine kinase (Talbot and VanBerkum, 2006, Hsouna et al., 2003, Song et al., 2008, Stephan et al., 2008, Corrigall et al., 2007, Dorsten et al., 2007, Al-Anzi and Wyman, 2009) abl kinase (Fox et al., 2003) Abl oncogene (Gim et al., 2001) Abl tyrosine kinase (Kuzina et al., 2011) D-abelson (Loureiro et al., 1999)
Secondary FlyBase IDs
	FBgn0024512 FBgn0036649
References ( 273 )
Generate a list of	All references relating to this gene ( 273 )
List References by type	Research paper  ( 113 ) Supplementary material  ( 6 ) Review  ( 62 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 69 ) FlyBase analysis  ( 3 ) Conference report  ( 1 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 8 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Kuzina et al., 2011, Development 138(9): 1839--1849 How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493] O'Keefe et al., 2011, Mech. Dev. 128(1-2): 59--70 EndoGI modulates Notch signaling and axon guidance in Drosophila. [FBrf0213012] Dorsten et al., 2010, PLoS ONE 5(3): e9822 In the absence of frazzled over-expression of abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS. [FBrf0210365] Foley et al., 2010, Biol. Letts 6(1): 102--105 Does segregating variation in sexual or microhabitat preferences lead to non-random mating within a population of Drosophila melanogaster? [FBrf0209672] Lowery et al., 2010, Genetics 185(4): 1311--1325 Parallel Genetic and Proteomic Screens Identify Msps as a CLASP-Abl Pathway Interactor in Drosophila. [FBrf0211499] Oliva and Sierralta, 2010, Dev. Biol. 344(2): 911--921 Regulation of axonal development by the nuclear protein hindsight (pebbled) in the Drosophila visual system. [FBrf0211428] Song et al., 2010, Development 137(21): 3719--3727 Disabled is a bona fide component of the Abl signaling network. [FBrf0212092] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...