• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\abo

General Information
Symbol	Dmel\abo	Species	D. melanogaster
Name	abnormal oocyte	Annotation symbol	CG6093
Feature type	protein_coding_gene	FlyBase ID	FBgn0000018
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map	2-44.0
Cytogenetic map	32C1-32C1	Sequence location	2L:10,973,443..10,975,273 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene abnormal oocyte is referred to in FlyBase by the symbol Dmel\abo (CG6093, FBgn0000018). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: oogenesis; negative regulation of transcription from RNA polymerase II promoter. 9 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic head; extended germ band embryo. It has one annotated transcript and one annotated polypeptide. Protein features are: De-etiolated protein 1, Det1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1628418_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of abo. Gene sequence location is 2L:10973443..10975273.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	abo: abnormal oocyte Probability of survival of embryos produced by abo/abo mothers reduced; male embryos more severely affected than female embryos. Both preblastoderm and postblastoderm embryonic death observed; partial rescue of postblastoderm mortality effected by paternally inherited abo+ allele; partial rescue of preblastoderm mortality by heterochromatic ABO elements located in Xh between 3/4 and 7/8 of the distance from the centromere, in YL region h10-11, in YS region h19, in 2R proximal, and perhaps in other heterochromatic regions (Pimpinelli, Sullivan, Prout, and Sandler, 1985, Genetics 109: 701-24). Gradual loss of phenotype in homozygous abo stocks accompanied by increase in quantity of ribosomal DNA (Krider and Levine, 1975, Genetics 81: 501-13). New restriction fragments appear in Hind III/Hae III double digests of such homozygous lines probed with nontranscribed spacer sequences of ribosomal genes (Graziani, Vicari, Boncinelli, Malva, Manzi, and Mariani, 1981, Proc. Nat. Acad. Sci. USA 78: 7662-64). abo phenotype returns with subsequent maintenance in heterozygous condition. Homozygous abo females exhibit moderate decrease in recombination with concommitant increase in exceptional progeny (Carpenter and Sandler, 1974, Genetics 76: 453-75).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN20470 HFA02926
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32C1-32C1   Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32C-32C   (determined by in situ hybridisation)   (Tomkiel et al., 1995) 32E-32E   (determined by in situ hybridisation)   (Cavaliere et al., 1991)
Experimentally Determined Recombination Data
Location	2-44.0
Left of (cM)	noc (Tomkiel et al., 1995)
Right of (cM)	J (Tomkiel et al., 1995)
Notes	Mapped with respect to J.   abo2 mapped between 2-41.7 and 2-43.1, abo1 mapped to 2-44.0. (Tomkiel et al., 1995)
Gene Model & Products
Please see the GBrowse view of Dmel\abo for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) abo-RA FBtr0080168  NM_080045   1774   539
Additional Transcript Data & Comments
Reported size (kB)	1.8 (northern blot) (Tomkiel et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein abo-PA   FBpp0079757   62.4   539   7.62     NP_524784   AAF53040
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • De-etiolated protein 1, Det1 (IPR019138)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140822   AE014134 AAF53040   AF384149 AAL08945   AY121704 AAM52031   BG637328   BI566768   BI633235   BI637011   BI637144   BI637210   BI640133   BI640242   CL943568   CO308702   EC087424   EC203807   GO271040   X17392   X17393
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MR99 Q95W10 Q9VKM4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000018    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000018 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000018 expression level Developmental Stage   Expression Level embryo 00-02hr    1202 embryo 02-04hr    193 embryo 04-06hr    229 embryo 06-08hr    255 embryo 08-10hr    257 embryo 10-12hr    183 embryo 12-14hr    181 embryo 14-16hr    151 embryo 16-18hr    117 embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1    254 larva L2    290 larva L3 12hr old    218 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    371 larva L3 puffstage 7-9    417 white prepupae new    363 white prepupae 12hr    410 white prepupae 24hr    457 pupae 2d postWPP    376 pupae 3d postWPP    257 pupae 4d postWPP    299 adult male 01day    374 adult male 05day    543 adult male 30day    526 adult female 01day    599 adult female 05day    834 adult female 30day    865 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1202) embryo 02-04hr  (193) embryo 04-06hr  (229) embryo 06-08hr  (255) embryo 08-10hr  (257) embryo 10-12hr  (183) embryo 12-14hr  (181) embryo 14-16hr  (151) embryo 16-18hr  (117) embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1  (254) larva L2  (290) larva L3 12hr old  (218) larva L3 puffstage 1-2  (342) larva L3 puffstage 3-6  (371) larva L3 puffstage 7-9  (417) white prepupae new  (363) white prepupae 12hr  (410) white prepupae 24hr  (457) pupae 2d postWPP  (376) pupae 3d postWPP  (257) pupae 4d postWPP  (299) adult male 01day  (374) adult male 05day  (543) adult male 30day  (526) adult female 01day  (599) adult female 05day  (834) adult female 30day  (865) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1202 embryo 02-04hr    193 embryo 04-06hr    229 embryo 06-08hr    255 embryo 08-10hr    257 embryo 10-12hr    183 embryo 12-14hr    181 embryo 14-16hr    151 embryo 16-18hr    117 embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1    254 larva L2    290 larva L3 12hr old    218 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    371 larva L3 puffstage 7-9    417 white prepupae new    363 white prepupae 12hr    410 white prepupae 24hr    457 pupae 2d postWPP    376 pupae 3d postWPP    257 pupae 4d postWPP    299 adult male 01day    374 adult male 05day    543 adult male 30day    526 adult female 01day    599 adult female 05day    834 adult female 30day    865 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1202 embryo 02-04hr    193 embryo 04-06hr    229 embryo 06-08hr    255 embryo 08-10hr    257 embryo 10-12hr    183 embryo 12-14hr    181 embryo 14-16hr    151 embryo 16-18hr    117 embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1    254 larva L2    290 larva L3 12hr old    218 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    371 larva L3 puffstage 7-9    417 white prepupae new    363 white prepupae 12hr    410 white prepupae 24hr    457 pupae 2d postWPP    376 pupae 3d postWPP    257 pupae 4d postWPP    299 adult male 01day    374 adult male 05day    543 adult male 30day    526 adult female 01day    599 adult female 05day    834 adult female 30day    865 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1202 embryo 02-04hr    193 embryo 04-06hr    229 embryo 06-08hr    255 embryo 08-10hr    257 embryo 10-12hr    183 embryo 12-14hr    181 embryo 14-16hr    151 embryo 16-18hr    117 embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1    254 larva L2    290 larva L3 12hr old    218 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    371 larva L3 puffstage 7-9    417 white prepupae new    363 white prepupae 12hr    410 white prepupae 24hr    457 pupae 2d postWPP    376 pupae 3d postWPP    257 pupae 4d postWPP    299 adult male 01day    374 adult male 05day    543 adult male 30day    526 adult female 01day    599 adult female 05day    834 adult female 30day    865 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000018 expression level Developmental Stage   Expression Level embryo 00-02hr    1202 embryo 02-04hr    193 embryo 04-06hr    229 embryo 06-08hr    255 embryo 08-10hr    257 embryo 10-12hr    183 embryo 12-14hr    181 embryo 14-16hr    151 embryo 16-18hr    117 embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1    254 larva L2    290 larva L3 12hr old    218 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    371 larva L3 puffstage 7-9    417 white prepupae new    363 white prepupae 12hr    410 white prepupae 24hr    457 pupae 2d postWPP    376 pupae 3d postWPP    257 pupae 4d postWPP    299 adult male 01day    374 adult male 05day    543 adult male 30day    526 adult female 01day    599 adult female 05day    834 adult female 30day    865 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1202) embryo 02-04hr  (193) embryo 04-06hr  (229) embryo 06-08hr  (255) embryo 08-10hr  (257) embryo 10-12hr  (183) embryo 12-14hr  (181) embryo 14-16hr  (151) embryo 16-18hr  117 embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1  (254) larva L2  (290) larva L3 12hr old  (218) larva L3 puffstage 1-2  (342) larva L3 puffstage 3-6  (371) larva L3 puffstage 7-9  (417) white prepupae new  (363) white prepupae 12hr  (410) white prepupae 24hr  (457) pupae 2d postWPP  (376) pupae 3d postWPP  (257) pupae 4d postWPP  (299) adult male 01day  (374) adult male 05day  (543) adult male 30day  (526) adult female 01day  (599) adult female 05day  (834) adult female 30day  (865) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1202 embryo 02-04hr    193 embryo 04-06hr    229 embryo 06-08hr    255 embryo 08-10hr    257 embryo 10-12hr    183 embryo 12-14hr    181 embryo 14-16hr    151 embryo 16-18hr    117 embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1    254 larva L2    290 larva L3 12hr old    218 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    371 larva L3 puffstage 7-9    417 white prepupae new    363 white prepupae 12hr    410 white prepupae 24hr    457 pupae 2d postWPP    376 pupae 3d postWPP    257 pupae 4d postWPP    299 adult male 01day    374 adult male 05day    543 adult male 30day    526 adult female 01day    599 adult female 05day    834 adult female 30day    865 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1202 embryo 02-04hr    193 embryo 04-06hr    229 embryo 06-08hr    255 embryo 08-10hr    257 embryo 10-12hr    183 embryo 12-14hr    181 embryo 14-16hr    151 embryo 16-18hr    117 embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1    254 larva L2    290 larva L3 12hr old    218 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    371 larva L3 puffstage 7-9    417 white prepupae new    363 white prepupae 12hr    410 white prepupae 24hr    457 pupae 2d postWPP    376 pupae 3d postWPP    257 pupae 4d postWPP    299 adult male 01day    374 adult male 05day    543 adult male 30day    526 adult female 01day    599 adult female 05day    834 adult female 30day    865 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1202 embryo 02-04hr    193 embryo 04-06hr    229 embryo 06-08hr    255 embryo 08-10hr    257 embryo 10-12hr    183 embryo 12-14hr    181 embryo 14-16hr    151 embryo 16-18hr    117 embryo 18-20hr    84 embryo 20-22hr    93 embryo 22-24hr    98 larva L1    254 larva L2    290 larva L3 12hr old    218 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    371 larva L3 puffstage 7-9    417 white prepupae new    363 white prepupae 12hr    410 white prepupae 24hr    457 pupae 2d postWPP    376 pupae 3d postWPP    257 pupae 4d postWPP    299 adult male 01day    374 adult male 05day    543 adult male 30day    526 adult female 01day    599 adult female 05day    834 adult female 30day    865 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000018    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000018 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000018 expression level Tissue   Expression Level Larval Central Nervous System    78.275 Larval Midgut    65.4 Larval Hindgut    75.6 Larval Malpighian Tubules    71.3 Larval Fat Body    65.7 Larval Salivary Gland    92.1 Larval Trachea    93.025 Larval Carcass    71.225 Adult Head    40.1 Adult Eye    36.575 Adult Brain    26.8 Adult Thoracic-Abdominal Ganglion    37.4 Adult Crop    71.4 Adult Midgut    76.1 Adult Hindgut    55.3 Adult Malpighian Tubules    70.8 Adult Fat Body    67.4 Adult Salivary Gland    74.2 Adult Heart    56.475 Adult VirginFemale Spermatheca    58.4 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    168.2 Adult Testis    86.7 Adult Male Accessory Gland    81.7 Adult Carcass    47.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    78.275 Larval Midgut    65.4 Larval Hindgut    75.6 Larval Malpighian Tubules    71.3 Larval Fat Body    65.7 Larval Salivary Gland    92.1 Larval Trachea    93.025 Larval Carcass    71.225 Adult Head    40.1 Adult Eye    36.575 Adult Brain    26.8 Adult Thoracic-Abdominal Ganglion    37.4 Adult Crop    71.4 Adult Midgut    76.1 Adult Hindgut    55.3 Adult Malpighian Tubules    70.8 Adult Fat Body    67.4 Adult Salivary Gland    74.2 Adult Heart    56.475 Adult VirginFemale Spermatheca    58.4 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    168.2 Adult Testis    86.7 Adult Male Accessory Gland    81.7 Adult Carcass    47.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    78.275 Larval Midgut    65.4 Larval Hindgut    75.6 Larval Malpighian Tubules    71.3 Larval Fat Body    65.7 Larval Salivary Gland    92.1 Larval Trachea    93.025 Larval Carcass    71.225 Adult Head    40.1 Adult Eye    36.575 Adult Brain    26.8 Adult Thoracic-Abdominal Ganglion    37.4 Adult Crop    71.4 Adult Midgut    76.1 Adult Hindgut    55.3 Adult Malpighian Tubules    70.8 Adult Fat Body    67.4 Adult Salivary Gland    74.2 Adult Heart    56.475 Adult VirginFemale Spermatheca    58.4 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    168.2 Adult Testis    86.7 Adult Male Accessory Gland    81.7 Adult Carcass    47.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    78.275 Larval Midgut    65.4 Larval Hindgut    75.6 Larval Malpighian Tubules    71.3 Larval Fat Body    65.7 Larval Salivary Gland    92.1 Larval Trachea    93.025 Larval Carcass    71.225 Adult Head    40.1 Adult Eye    36.575 Adult Brain    26.8 Adult Thoracic-Abdominal Ganglion    37.4 Adult Crop    71.4 Adult Midgut    76.1 Adult Hindgut    55.3 Adult Malpighian Tubules    70.8 Adult Fat Body    67.4 Adult Salivary Gland    74.2 Adult Heart    56.475 Adult VirginFemale Spermatheca    58.4 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    168.2 Adult Testis    86.7 Adult Male Accessory Gland    81.7 Adult Carcass    47.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000018 expression level Tissue   Expression Level Larval Central Nervous System    78.275 Larval Midgut    65.4 Larval Hindgut    75.6 Larval Malpighian Tubules    71.3 Larval Fat Body    65.7 Larval Salivary Gland    92.1 Larval Trachea    93.025 Larval Carcass    71.225 Adult Head    40.1 Adult Eye    36.575 Adult Brain    26.8 Adult Thoracic-Abdominal Ganglion    37.4 Adult Crop    71.4 Adult Midgut    76.1 Adult Hindgut    55.3 Adult Malpighian Tubules    70.8 Adult Fat Body    67.4 Adult Salivary Gland    74.2 Adult Heart    56.475 Adult VirginFemale Spermatheca    58.4 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    168.2 Adult Testis    86.7 Adult Male Accessory Gland    81.7 Adult Carcass    47.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    78.275 Larval Midgut    65.4 Larval Hindgut    75.6 Larval Malpighian Tubules    71.3 Larval Fat Body    65.7 Larval Salivary Gland    92.1 Larval Trachea    93.025 Larval Carcass    71.225 Adult Head    40.1 Adult Eye    36.575 Adult Brain    26.8 Adult Thoracic-Abdominal Ganglion    37.4 Adult Crop    71.4 Adult Midgut    76.1 Adult Hindgut    55.3 Adult Malpighian Tubules    70.8 Adult Fat Body    67.4 Adult Salivary Gland    74.2 Adult Heart    56.475 Adult VirginFemale Spermatheca    58.4 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    168.2 Adult Testis    86.7 Adult Male Accessory Gland    81.7 Adult Carcass    47.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    78.275 Larval Midgut    65.4 Larval Hindgut    75.6 Larval Malpighian Tubules    71.3 Larval Fat Body    65.7 Larval Salivary Gland    92.1 Larval Trachea    93.025 Larval Carcass    71.225 Adult Head    40.1 Adult Eye    36.575 Adult Brain    26.8 Adult Thoracic-Abdominal Ganglion    37.4 Adult Crop    71.4 Adult Midgut    76.1 Adult Hindgut    55.3 Adult Malpighian Tubules    70.8 Adult Fat Body    67.4 Adult Salivary Gland    74.2 Adult Heart    56.475 Adult VirginFemale Spermatheca    58.4 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    168.2 Adult Testis    86.7 Adult Male Accessory Gland    81.7 Adult Carcass    47.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    78.275 Larval Midgut    65.4 Larval Hindgut    75.6 Larval Malpighian Tubules    71.3 Larval Fat Body    65.7 Larval Salivary Gland    92.1 Larval Trachea    93.025 Larval Carcass    71.225 Adult Head    40.1 Adult Eye    36.575 Adult Brain    26.8 Adult Thoracic-Abdominal Ganglion    37.4 Adult Crop    71.4 Adult Midgut    76.1 Adult Hindgut    55.3 Adult Malpighian Tubules    70.8 Adult Fat Body    67.4 Adult Salivary Gland    74.2 Adult Heart    56.475 Adult VirginFemale Spermatheca    58.4 Adult InseminatedFemale Spermatheca    65.5 Adult Ovary    168.2 Adult Testis    86.7 Adult Male Accessory Gland    81.7 Adult Carcass    47.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    40.1   NA  Eye    36.575   NA  Brain    26.8   78.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    37.4   NA  Crop    71.4   65.4  Midgut    76.1   75.6  Hindgut    55.3   71.3  Malpighian Tubules    70.8   65.7  Fat Body    67.4   92.1  Salivary Gland    74.2   NA  Heart    56.475   93.025  Trachea    NA   NA  VirginFemale Spermatheca    58.4   NA  InseminatedFemale Spermatheca    65.5   NA  Ovary    168.2   NA  Testis    86.7   NA  Male Accessory Gland    81.7   71.225  Carcass    47.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000018 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6093-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | maternal effect | recessive abo2 lethal | recessive abo2rev lethal | rescuable maternal effect abo1 viable aboEY13277 viable, with Scer\GAL4pnr-MD237 aboGD11814 Sterility Allele female sterile abo1 fertile aboEY13277 Phenotype manifest in Allele embryonic/first instar larval cuticle abo1 embryonic head abo1 extended germ band embryo abo1
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of abo Class Mutagen Stocks Known lesion abo1 spontaneous natural population 3 Yes abod01007 P-element activity 3 -- aboEY13277 P-element activity 1 -- abo2 Delta2-3 P-element activity 0 Yes abo2rev Delta2-3 0 -- abounspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of abo Class Mutagen Stocks Known lesion aboGD11814 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aboKK100374 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes abotTa in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7049 (Ryder, 2004.4.26) Df(2L)J39 (Sinclair et al., 1992)
Not disrupted in	Df(2L)J77 (Salas and Lengyel, 1984) Df(2L)J106 (Salas and Lengyel, 1984) Df(2L)J233 (Salas and Lengyel, 1984) T(Y;2)Jrv99 (Salas and Lengyel, 1984)
Duplicated in	Dp(2;2)Mdh (Tomkiel et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11814} NA P{KK100374} NA characterization construct P{abo9.0} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}aboEY13277 NA P{XP}abod01007 NA miscellaneous insertions Doc{}abo1 NA P{PTT-GB}CB03272 NA P{ry11}abo2 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Berloco et al., 2001)
Biological Process
CV term Evidence References
negative regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Berloco et al., 2001) oogenesis inferred from mutant phenotype (Malva et al., 1994)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Berloco et al., 2001) polytene chromosome inferred from direct assay (Berloco et al., 2001)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions abo allele Gene References abounspecified ABO-X (Malva et al., 1985)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000018 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44793
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14049 Dere\GG10339 Dgri\GH20884 Dmoj\GI18896 Dper\GL19021 Dpse\GA19346 Dsec\GM11247 Dsim\GD22208 Dvir\GJ20719 Dwil\GK14891 Dyak\GE13132
Curated drosophilid orthologs	Dpse\GA19346   Dsim\abo (Rodriguez and Malik, 2005)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008161-PA Aedes aegypti (mosquito) AGAP001900-PA Anopheles gambiae (mosquito) XP_623769.1 Apis mellifera (honey bee) XP_001944215.1 Acyrthosiphon pisum (pea aphid) At4g10180.1 Arabidopsis thaliana (wall cress) 21492 Batrachochytrium dendrobatidis (chytrid fungus) 123210 Branchiostoma floridae (lancelet) 282254 Branchiostoma floridae (lancelet) BGIBMGA001427-PA Bombyx mori (silk worm) ENSBTAP00000001281 Bos taurus (bovine) ENSCAFP00000016919 Canis familiaris (dog) CPIJ008362 Culex pipens (mosquito) ENSCPOP00000013059 Cavia porcellus (guinea pig) ENSCSAVP00000019488 Ciona savignyi (sedentary tunicate) 130430 Capitella spl (polychaete worm) 208808 Capitella spl (polychaete worm) DDB0217895 Dictyostelium discoideum (amoeba) 306042 Daphnia pulex (daphnia) ENSDARP00000017003 Danio rerio (zebra fish) ENSECAP00000018724 Equus caballus (horse) ENSGACP00000004129 Gymnopilus aculeatus (mushroom) ENSGALP00000010895 Gallus gallus (chicken) 64519 Hypsipyla robusta (cedar shoot borer) ENSP00000268148 Homo sapiens (human) ISCW008557-PA Ixodes scapularis (deer tick) 121100 Lottia gigantea (owl limpet) ENSMODP00000024438 Monodelphis domestica (gray opossum) ENSMMUP00000033298 Macaca mulatta (rhesus monkey) ENSMUSP00000032839 Mus musculus (house mouse) 211865 Nematostella vectensis (starlet anemone) XP_001606651.1 Nasonia vitripennis (wasp) ENSOANP00000019317 Ornithorynchus anatinus (platypus) ENSORLP00000015878 Oryzias latipes (japanese killifish) LOC_Os01g01484.1 Oryza sativa (asian rice) 28786 Ostreococcus tauri (green alga) PHUM001882-PA Pediculus humanus (human body louse) 195255 Physcomitrella patens (moss) ENSPPYP00000007661 Pongo pygmaeus (orangutan) 807189 Populus trichocarpa (black cottonwood) ENSPTRP00000012680 Pan troglodytes (chimpanzee) ENSRNOP00000024985 Rattus norvegicus (norway rat) 5043153 Sorghum bicolor (sorghum) XP_001186916.1 Strongylocentrotus purpuratus (purple sea urchin) 50870 Trichoplax adhaerens (metazoa) XP_974608.1 Tribolium castaneum (red flour beetle) ENSTNIP00000006451 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014240 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000016522 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15080 NV12778 LH16018 ISCW008557 FBgn0230830 FBgn0216896 FBgn0207857 FBgn0193617 FBgn0166192 JGI_V11_306042 FBgn0079343 FBgn0156622 FBgn0141635 FBgn0128346 FBgn0102648 FBgn0091076 CPIJ008362 BGIBMGA001427 ACYPI008749 ACYPI003567 GB14535 AGAP001900 AAEL008161 PHUM307480 GLEAN_13372
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	2525 abo1/SM1 19158 w1118; P{XP}abod01007/CyO 20870 y1 w67c23; P{EPgy2}aboEY13277
Harvard	- P{XP}abod01007
Kyoto	107382 abo1/SM1 101421 da1 abo1 / In(2L)Cy, In(2R)Cy, Cy1 cn2 114557 yd2 w1118 P{ey-FLP.N}2; P{XP}abod01007 P{neoFRT}40A/CyO y+
VDRC	v105384 P{KK100374}VIE-260B v27562 w1118; P{GD11814}v27562
Genomic Clones ( 2 )
	BACR03D06 BACR20O15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 13 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH36510
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD15248 SD18888 SD19069 SD19157 SD22931 SD23053 SD27272
Other clones	84247 156409 CK00491 DMG7-chr2L.20.016.pred.a EK259139
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000018 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44793
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: abo CG6093 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	abo appears to be a negative regulator of histone transcription. (Berloco et al., 2001) The insertion of the blood transposon in region 32E causes the pleiotropic abo mutant phenotype. (Cavaliere et al., 1991) Progeny survival from abo mothers depends in part upon the maternal dosage of ABO-X heterochromatin: recovery of daughters decreased if the mother was ABO-X-/ABO-X- and increased if they received an ABO-X- X chromosome from a heterozygote mother. These results suggest an interactive effect between the ABO-X deficient X and the ABO-X heterochromatin in the maternal genome. The ABO-X heterochromatin on the X chromosome rescues zygotes from the abo maternal effect prior to the completion of the first zygotic division. (Tomkiel et al., 1991) Maintained homozygous abo stocks show a decrease in maternally-induced embryonic lethality over time. The altered genetic factors responsible are abo-responsive heterochromatic rescuing regions that act zygotically, dominantly and additively to reduce lethality. The regions map to the second and X chromosome in the maintained homozygous abo stock. (Sullivan and Pimpinelli, 1986) Embryos, especially male, from females homozygous for abo mutant alleles have a reduced probability of survival, dying both before and after blastoderm formation. Postblastoderm lethality can be partially rescued by a paternal wild-type allele and preblastoderm lethality by the maternal effect of heterochromatic elements on the X, Y and 2R (defined as ABO-X, ABO-YL, ABO-YS and ABO-2R).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080045 RefSeq (Proteins) • NP_524784 DDBJ / EMBL / GenBank • AAF53040 AAL08945 AAM52031 AF384149 AY121704 BI566768 CL943568 X17392 X17393 Entrez Gene - A searchable database of RefSeq genes. • 44793 UniProtKB/TrEMBL • Q8MR99 Q9VKM4 Q95W10
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • De-etiolated protein 1, Det1 (IPR019138)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000018 DRSC - Results from RNAi screens. • FBgn0000018 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000018 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6093-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000018 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44793 InParanoid A subset of ortholog calls from InParanoid. • AAEL008161-PA Aedes aegypti (mosquito) AGAP001900-PA Anopheles gambiae (mosquito) XP_623769.1 Apis mellifera (honey bee) XP_001944215.1 Acyrthosiphon pisum (pea aphid) At4g10180.1 Arabidopsis thaliana (wall cress) 21492 Batrachochytrium dendrobatidis (chytrid fungus) 123210 Branchiostoma floridae (lancelet) 282254 Branchiostoma floridae (lancelet) BGIBMGA001427-PA Bombyx mori (silk worm) ENSBTAP00000001281 Bos taurus (bovine) ENSCAFP00000016919 Canis familiaris (dog) CPIJ008362 Culex pipens (mosquito) ENSCPOP00000013059 Cavia porcellus (guinea pig) ENSCSAVP00000019488 Ciona savignyi (sedentary tunicate) 130430 Capitella spl (polychaete worm) 208808 Capitella spl (polychaete worm) DDB0217895 Dictyostelium discoideum (amoeba) 306042 Daphnia pulex (daphnia) ENSDARP00000017003 Danio rerio (zebra fish) ENSECAP00000018724 Equus caballus (horse) ENSGACP00000004129 Gymnopilus aculeatus (mushroom) ENSGALP00000010895 Gallus gallus (chicken) 64519 Hypsipyla robusta (cedar shoot borer) ENSP00000268148 Homo sapiens (human) ISCW008557-PA Ixodes scapularis (deer tick) 121100 Lottia gigantea (owl limpet) ENSMODP00000024438 Monodelphis domestica (gray opossum) ENSMMUP00000033298 Macaca mulatta (rhesus monkey) ENSMUSP00000032839 Mus musculus (house mouse) 211865 Nematostella vectensis (starlet anemone) XP_001606651.1 Nasonia vitripennis (wasp) ENSOANP00000019317 Ornithorynchus anatinus (platypus) ENSORLP00000015878 Oryzias latipes (japanese killifish) LOC_Os01g01484.1 Oryza sativa (asian rice) 28786 Ostreococcus tauri (green alga) PHUM001882-PA Pediculus humanus (human body louse) 195255 Physcomitrella patens (moss) ENSPPYP00000007661 Pongo pygmaeus (orangutan) 807189 Populus trichocarpa (black cottonwood) ENSPTRP00000012680 Pan troglodytes (chimpanzee) ENSRNOP00000024985 Rattus norvegicus (norway rat) 5043153 Sorghum bicolor (sorghum) XP_001186916.1 Strongylocentrotus purpuratus (purple sea urchin) 50870 Trichoplax adhaerens (metazoa) XP_974608.1 Tribolium castaneum (red flour beetle) ENSTNIP00000006451 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014240 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000016522 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44793 modMine - Data generated by the modENCODE project. • FBgn0000018 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15080 NV12778 LH16018 ISCW008557 FBgn0230830 FBgn0216896 FBgn0207857 FBgn0193617 FBgn0166192 JGI_V11_306042 FBgn0079343 FBgn0156622 FBgn0141635 FBgn0128346 FBgn0102648 FBgn0091076 CPIJ008362 BGIBMGA001427 ACYPI008749 ACYPI003567 GB14535 AGAP001900 AAEL008161 PHUM307480 GLEAN_13372
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	abo (Buszczak et al., 2007, Cohen et al., 2005, Doheny et al., 2008) CG6093 (Keleman et al., 2009.8.5)
Name Synonym	abnormal oocyte (Doheny et al., 2008)
Secondary FlyBase IDs
	FBgn0032323
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 2 ) Review  ( 8 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Computer file  ( 2 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...