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Gene Dmel\Acph-1

General Information
Symbol	Dmel\Acph-1	Species	D. melanogaster
Name	Acid phosphatase 1	Annotation symbol	CG7899
Feature type	protein_coding_gene	FlyBase ID	FBgn0000032
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	ACPH
Genomic Location
Chromosome (arm)	3R	Recombination map	3-101.1
Cytogenetic map	99D1-99D1	Sequence location	3R:25,816,861..25,819,130 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Acid phosphatase 1 is referred to in FlyBase by the symbol Dmel\Acph-1 (CG7899, FBgn0000032). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: acid phosphatase activity. The biological processes in which it is involved are not known. 31 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Histidine phosphatase superfamily, clade-2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640265_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Acph-1. Gene sequence location is 3R:25816861..25819130.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Acph-1: Acid phosphatase 1 Structural gene for acid phosphatase 1 [ACPH-1 (EC3.1.3.2)], the major phosphatase in adults; responsible for approximately 90% of the low-pH nucleotidase activity throughout development. Glycoprotein homodimer with subunit molecular weight of 50,000 daltons. Purification and biochemical characterization by Feigen, Mitrick, Johns, Postlethwait, and Sederoff (1980, J. Biol. Chem. 255: 10338-43). Serves as a reliable cytochemical marker in many tissues (Hall, 1979, Genetics 92: 437-57). Enzyme appears to be produced in nurse cells and follicular cells of ovary and transferred to oocyte through the ring canals and by pinocytosis, respectively (Sawicki and MacIntyre, 1977, Dev. Biol. 60: 1-13); maternally produced enzyme persists to third instar; paternal gene function detectable in gels after 9-10 hr of embryonic development (Yasbin, Sawicki, and MacIntyre, 1978, Dev. Biol. 63: 35-46); and after 5 hr histochemically (Sawicki and MacIntyre, 1978, Dev. Biol. 63: 47-58). Enzyme found in larvae, pupae, and adults; levels increase during adult life (Postlethwait and Gray, 1975, Dev. Biol. 47: 196-205).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features BKN60507 BKN60043 BKN22061 HFA14103
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99D1-99D1   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99C5-99C7   (determined by in situ hybridisation)   (Ranz et al., 1997) 99D-99D   (determined by in situ hybridisation)   (Segarra et al., 1996) 99C-99C   (determined by in situ hybridisation)   (Shaffer and MacIntyre, 1990)
Experimentally Determined Recombination Data
Location	3-101.1   3- (Choudhary et al., 1992)
Left of (cM)	bv
Right of (cM)	ca
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Acph-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Acph-1-RA FBtr0085609  NM_080178   1944   438 Acph-1-RB FBtr0085610  NM_170453   1894   455
Additional Transcript Data & Comments
Reported size (kB)	2.1 (northern blot) (Shaffer and MacIntyre, 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Acph-1-PA   FBpp0084974   50.1   438   6.67     NP_524917   AAF56981 Acph-1-PB   FBpp0084975   52.0   455   7.51     NP_733332   AAN14203
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Histidine phosphatase superfamily, clade-2 (IPR000560)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390566   AA439525   AA440182   AA440803   AA695021   AA941506   AA951871   AE014297 AAF56981   AE014297 AAN14203   AI514859   AI514937   AI516637   AI546199   AI546381   AY071077 AAL48699   BG636512   BG639245   BI162680   BI162681   BI171193   BI172147   BI172347   BI213819   BI214116   BI229804   BI234092   BI243337   BI356348   BI362051   BI362663   BI362776   BI366604   BI368406   BI368884   BI375644   BI483747   BI576599   BI579100   BI586090   BI640318   BP547689   BP556456   BT001641 AAN71396   CO184028   CO271500   CO279665   CO293758   CO316231   EC060081   EC072904   EC201259   EC247236   EC248680   EL874373   EV577612   EV586862   EV589212   EV591695   EV591791   GH755998   GH776965   GH801339   GH804780   GH809783   GH822089   GH830065   GH831592   GH837032   GH855203   GH857251   GH857481   GH864091   GH865083   GH867194   GH871085   GH872399   GH872492   GH882236   GH882884   GH883072   GH883132   GH885576   GH887080   GH888430   GH894435   GH894829   GH904303   GH906033   GH906139   GH907431   GH914263   GH934694   GH936207
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8I0P9 Q9VAD0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | female     (Arbeitman et al., 2004) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Shaffer and MacIntyre, 1990) adult stage | female   germline cell   (Arbeitman et al., 2004)
Additional Descriptive Data
	Acph-1 transcripts are expressed throughout development. (Shaffer and MacIntyre, 1990)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000032    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000032 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000032 expression level Developmental Stage   Expression Level embryo 00-02hr    4567 embryo 02-04hr    2949 embryo 04-06hr    972 embryo 06-08hr    752 embryo 08-10hr    1548 embryo 10-12hr    1659 embryo 12-14hr    1898 embryo 14-16hr    1765 embryo 16-18hr    2683 embryo 18-20hr    1991 embryo 20-22hr    2307 embryo 22-24hr    2467 larva L1    603 larva L2    839 larva L3 12hr old    940 larva L3 puffstage 1-2    1330 larva L3 puffstage 3-6    1615 larva L3 puffstage 7-9    2278 white prepupae new    2328 white prepupae 12hr    2254 white prepupae 24hr    1395 pupae 2d postWPP    1307 pupae 3d postWPP    910 pupae 4d postWPP    566 adult male 01day    856 adult male 05day    1083 adult male 30day    855 adult female 01day    1737 adult female 05day    3571 adult female 30day    3380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4567) embryo 02-04hr  (2949) embryo 04-06hr  (972) embryo 06-08hr  (752) embryo 08-10hr  (1548) embryo 10-12hr  (1659) embryo 12-14hr  (1898) embryo 14-16hr  (1765) embryo 16-18hr  (2683) embryo 18-20hr  (1991) embryo 20-22hr  (2307) embryo 22-24hr  (2467) larva L1  (603) larva L2  (839) larva L3 12hr old  (940) larva L3 puffstage 1-2  (1330) larva L3 puffstage 3-6  (1615) larva L3 puffstage 7-9  (2278) white prepupae new  (2328) white prepupae 12hr  (2254) white prepupae 24hr  (1395) pupae 2d postWPP  (1307) pupae 3d postWPP  (910) pupae 4d postWPP  (566) adult male 01day  (856) adult male 05day  (1083) adult male 30day  (855) adult female 01day  (1737) adult female 05day  (3571) adult female 30day  (3380) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4567) embryo 02-04hr  (2949) embryo 04-06hr    972 embryo 06-08hr    752 embryo 08-10hr  (1548) embryo 10-12hr  (1659) embryo 12-14hr  (1898) embryo 14-16hr  (1765) embryo 16-18hr  (2683) embryo 18-20hr  (1991) embryo 20-22hr  (2307) embryo 22-24hr  (2467) larva L1    603 larva L2    839 larva L3 12hr old    940 larva L3 puffstage 1-2    1330 larva L3 puffstage 3-6  (1615) larva L3 puffstage 7-9  (2278) white prepupae new  (2328) white prepupae 12hr  (2254) white prepupae 24hr    1395 pupae 2d postWPP    1307 pupae 3d postWPP    910 pupae 4d postWPP    566 adult male 01day    856 adult male 05day    1083 adult male 30day    855 adult female 01day  (1737) adult female 05day  (3571) adult female 30day  (3380) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4567 embryo 02-04hr    2949 embryo 04-06hr    972 embryo 06-08hr    752 embryo 08-10hr    1548 embryo 10-12hr    1659 embryo 12-14hr    1898 embryo 14-16hr    1765 embryo 16-18hr    2683 embryo 18-20hr    1991 embryo 20-22hr    2307 embryo 22-24hr    2467 larva L1    603 larva L2    839 larva L3 12hr old    940 larva L3 puffstage 1-2    1330 larva L3 puffstage 3-6    1615 larva L3 puffstage 7-9    2278 white prepupae new    2328 white prepupae 12hr    2254 white prepupae 24hr    1395 pupae 2d postWPP    1307 pupae 3d postWPP    910 pupae 4d postWPP    566 adult male 01day    856 adult male 05day    1083 adult male 30day    855 adult female 01day    1737 adult female 05day    3571 adult female 30day    3380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4567 embryo 02-04hr    2949 embryo 04-06hr    972 embryo 06-08hr    752 embryo 08-10hr    1548 embryo 10-12hr    1659 embryo 12-14hr    1898 embryo 14-16hr    1765 embryo 16-18hr    2683 embryo 18-20hr    1991 embryo 20-22hr    2307 embryo 22-24hr    2467 larva L1    603 larva L2    839 larva L3 12hr old    940 larva L3 puffstage 1-2    1330 larva L3 puffstage 3-6    1615 larva L3 puffstage 7-9    2278 white prepupae new    2328 white prepupae 12hr    2254 white prepupae 24hr    1395 pupae 2d postWPP    1307 pupae 3d postWPP    910 pupae 4d postWPP    566 adult male 01day    856 adult male 05day    1083 adult male 30day    855 adult female 01day    1737 adult female 05day    3571 adult female 30day    3380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000032 expression level Developmental Stage   Expression Level embryo 00-02hr    4567 embryo 02-04hr    2949 embryo 04-06hr    972 embryo 06-08hr    752 embryo 08-10hr    1548 embryo 10-12hr    1659 embryo 12-14hr    1898 embryo 14-16hr    1765 embryo 16-18hr    2683 embryo 18-20hr    1991 embryo 20-22hr    2307 embryo 22-24hr    2467 larva L1    603 larva L2    839 larva L3 12hr old    940 larva L3 puffstage 1-2    1330 larva L3 puffstage 3-6    1615 larva L3 puffstage 7-9    2278 white prepupae new    2328 white prepupae 12hr    2254 white prepupae 24hr    1395 pupae 2d postWPP    1307 pupae 3d postWPP    910 pupae 4d postWPP    566 adult male 01day    856 adult male 05day    1083 adult male 30day    855 adult female 01day    1737 adult female 05day    3571 adult female 30day    3380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4567) embryo 02-04hr  (2949) embryo 04-06hr  (972) embryo 06-08hr  (752) embryo 08-10hr  (1548) embryo 10-12hr  (1659) embryo 12-14hr  (1898) embryo 14-16hr  (1765) embryo 16-18hr  (2683) embryo 18-20hr  (1991) embryo 20-22hr  (2307) embryo 22-24hr  (2467) larva L1  (603) larva L2  (839) larva L3 12hr old  (940) larva L3 puffstage 1-2  (1330) larva L3 puffstage 3-6  (1615) larva L3 puffstage 7-9  (2278) white prepupae new  (2328) white prepupae 12hr  (2254) white prepupae 24hr  (1395) pupae 2d postWPP  (1307) pupae 3d postWPP  (910) pupae 4d postWPP  (566) adult male 01day  (856) adult male 05day  (1083) adult male 30day  (855) adult female 01day  (1737) adult female 05day  (3571) adult female 30day  (3380) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4567) embryo 02-04hr  (2949) embryo 04-06hr    972 embryo 06-08hr    752 embryo 08-10hr  1548 embryo 10-12hr  1659 embryo 12-14hr  1898 embryo 14-16hr  1765 embryo 16-18hr  (2683) embryo 18-20hr  1991 embryo 20-22hr  2307 embryo 22-24hr  2467 larva L1    603 larva L2    839 larva L3 12hr old    940 larva L3 puffstage 1-2    1330 larva L3 puffstage 3-6  1615 larva L3 puffstage 7-9  2278 white prepupae new  2328 white prepupae 12hr  2254 white prepupae 24hr    1395 pupae 2d postWPP    1307 pupae 3d postWPP    910 pupae 4d postWPP    566 adult male 01day    856 adult male 05day    1083 adult male 30day    855 adult female 01day  1737 adult female 05day  (3571) adult female 30day  (3380) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4567 embryo 02-04hr    2949 embryo 04-06hr    972 embryo 06-08hr    752 embryo 08-10hr    1548 embryo 10-12hr    1659 embryo 12-14hr    1898 embryo 14-16hr    1765 embryo 16-18hr    2683 embryo 18-20hr    1991 embryo 20-22hr    2307 embryo 22-24hr    2467 larva L1    603 larva L2    839 larva L3 12hr old    940 larva L3 puffstage 1-2    1330 larva L3 puffstage 3-6    1615 larva L3 puffstage 7-9    2278 white prepupae new    2328 white prepupae 12hr    2254 white prepupae 24hr    1395 pupae 2d postWPP    1307 pupae 3d postWPP    910 pupae 4d postWPP    566 adult male 01day    856 adult male 05day    1083 adult male 30day    855 adult female 01day    1737 adult female 05day    3571 adult female 30day    3380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4567 embryo 02-04hr    2949 embryo 04-06hr    972 embryo 06-08hr    752 embryo 08-10hr    1548 embryo 10-12hr    1659 embryo 12-14hr    1898 embryo 14-16hr    1765 embryo 16-18hr    2683 embryo 18-20hr    1991 embryo 20-22hr    2307 embryo 22-24hr    2467 larva L1    603 larva L2    839 larva L3 12hr old    940 larva L3 puffstage 1-2    1330 larva L3 puffstage 3-6    1615 larva L3 puffstage 7-9    2278 white prepupae new    2328 white prepupae 12hr    2254 white prepupae 24hr    1395 pupae 2d postWPP    1307 pupae 3d postWPP    910 pupae 4d postWPP    566 adult male 01day    856 adult male 05day    1083 adult male 30day    855 adult female 01day    1737 adult female 05day    3571 adult female 30day    3380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000032    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000032 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000032 expression level Tissue   Expression Level Larval Central Nervous System    122.05 Larval Midgut    346.4 Larval Hindgut    233.6 Larval Malpighian Tubules    269.1 Larval Fat Body    307 Larval Salivary Gland    1026.9 Larval Trachea    285.4 Larval Carcass    235.75 Adult Head    80.5 Adult Eye    78.6 Adult Brain    111.5 Adult Thoracic-Abdominal Ganglion    112.1 Adult Crop    132.4 Adult Midgut    172.9 Adult Hindgut    127.2 Adult Malpighian Tubules    72.7 Adult Fat Body    128.4 Adult Salivary Gland    343.9 Adult Heart    194.8 Adult VirginFemale Spermatheca    194.1 Adult InseminatedFemale Spermatheca    196 Adult Ovary    518.4 Adult Testis    214.6 Adult Male Accessory Gland    524.8 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    122.05 Larval Midgut    346.4 Larval Hindgut    233.6 Larval Malpighian Tubules    269.1 Larval Fat Body    307 Larval Salivary Gland  (1026.9) Larval Trachea    285.4 Larval Carcass    235.75 Adult Head    80.5 Adult Eye    78.6 Adult Brain    111.5 Adult Thoracic-Abdominal Ganglion    112.1 Adult Crop    132.4 Adult Midgut    172.9 Adult Hindgut    127.2 Adult Malpighian Tubules    72.7 Adult Fat Body    128.4 Adult Salivary Gland    343.9 Adult Heart    194.8 Adult VirginFemale Spermatheca    194.1 Adult InseminatedFemale Spermatheca    196 Adult Ovary  518.4 Adult Testis    214.6 Adult Male Accessory Gland  524.8 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    122.05 Larval Midgut    346.4 Larval Hindgut    233.6 Larval Malpighian Tubules    269.1 Larval Fat Body    307 Larval Salivary Gland  1026.9 Larval Trachea    285.4 Larval Carcass    235.75 Adult Head    80.5 Adult Eye    78.6 Adult Brain    111.5 Adult Thoracic-Abdominal Ganglion    112.1 Adult Crop    132.4 Adult Midgut    172.9 Adult Hindgut    127.2 Adult Malpighian Tubules    72.7 Adult Fat Body    128.4 Adult Salivary Gland    343.9 Adult Heart    194.8 Adult VirginFemale Spermatheca    194.1 Adult InseminatedFemale Spermatheca    196 Adult Ovary    518.4 Adult Testis    214.6 Adult Male Accessory Gland    524.8 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    122.05 Larval Midgut    346.4 Larval Hindgut    233.6 Larval Malpighian Tubules    269.1 Larval Fat Body    307 Larval Salivary Gland    1026.9 Larval Trachea    285.4 Larval Carcass    235.75 Adult Head    80.5 Adult Eye    78.6 Adult Brain    111.5 Adult Thoracic-Abdominal Ganglion    112.1 Adult Crop    132.4 Adult Midgut    172.9 Adult Hindgut    127.2 Adult Malpighian Tubules    72.7 Adult Fat Body    128.4 Adult Salivary Gland    343.9 Adult Heart    194.8 Adult VirginFemale Spermatheca    194.1 Adult InseminatedFemale Spermatheca    196 Adult Ovary    518.4 Adult Testis    214.6 Adult Male Accessory Gland    524.8 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000032 expression level Tissue   Expression Level Larval Central Nervous System    122.05 Larval Midgut    346.4 Larval Hindgut    233.6 Larval Malpighian Tubules    269.1 Larval Fat Body    307 Larval Salivary Gland    1026.9 Larval Trachea    285.4 Larval Carcass    235.75 Adult Head    80.5 Adult Eye    78.6 Adult Brain    111.5 Adult Thoracic-Abdominal Ganglion    112.1 Adult Crop    132.4 Adult Midgut    172.9 Adult Hindgut    127.2 Adult Malpighian Tubules    72.7 Adult Fat Body    128.4 Adult Salivary Gland    343.9 Adult Heart    194.8 Adult VirginFemale Spermatheca    194.1 Adult InseminatedFemale Spermatheca    196 Adult Ovary    518.4 Adult Testis    214.6 Adult Male Accessory Gland    524.8 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    122.05 Larval Midgut    346.4 Larval Hindgut    233.6 Larval Malpighian Tubules    269.1 Larval Fat Body    307 Larval Salivary Gland  (1026.9) Larval Trachea    285.4 Larval Carcass    235.75 Adult Head    80.5 Adult Eye    78.6 Adult Brain    111.5 Adult Thoracic-Abdominal Ganglion    112.1 Adult Crop    132.4 Adult Midgut    172.9 Adult Hindgut    127.2 Adult Malpighian Tubules    72.7 Adult Fat Body    128.4 Adult Salivary Gland    343.9 Adult Heart    194.8 Adult VirginFemale Spermatheca    194.1 Adult InseminatedFemale Spermatheca    196 Adult Ovary  518.4 Adult Testis    214.6 Adult Male Accessory Gland  524.8 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    122.05 Larval Midgut    346.4 Larval Hindgut    233.6 Larval Malpighian Tubules    269.1 Larval Fat Body    307 Larval Salivary Gland  1026.9 Larval Trachea    285.4 Larval Carcass    235.75 Adult Head    80.5 Adult Eye    78.6 Adult Brain    111.5 Adult Thoracic-Abdominal Ganglion    112.1 Adult Crop    132.4 Adult Midgut    172.9 Adult Hindgut    127.2 Adult Malpighian Tubules    72.7 Adult Fat Body    128.4 Adult Salivary Gland    343.9 Adult Heart    194.8 Adult VirginFemale Spermatheca    194.1 Adult InseminatedFemale Spermatheca    196 Adult Ovary    518.4 Adult Testis    214.6 Adult Male Accessory Gland    524.8 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    122.05 Larval Midgut    346.4 Larval Hindgut    233.6 Larval Malpighian Tubules    269.1 Larval Fat Body    307 Larval Salivary Gland    1026.9 Larval Trachea    285.4 Larval Carcass    235.75 Adult Head    80.5 Adult Eye    78.6 Adult Brain    111.5 Adult Thoracic-Abdominal Ganglion    112.1 Adult Crop    132.4 Adult Midgut    172.9 Adult Hindgut    127.2 Adult Malpighian Tubules    72.7 Adult Fat Body    128.4 Adult Salivary Gland    343.9 Adult Heart    194.8 Adult VirginFemale Spermatheca    194.1 Adult InseminatedFemale Spermatheca    196 Adult Ovary    518.4 Adult Testis    214.6 Adult Male Accessory Gland    524.8 Adult Carcass    106.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    80.5   NA  Eye    78.6   NA  Brain    111.5   122.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    112.1   NA  Crop    132.4   346.4  Midgut    172.9   233.6  Hindgut    127.2   269.1  Malpighian Tubules    72.7   307  Fat Body    128.4   1026.9  Salivary Gland    343.9   NA  Heart    194.8   285.4  Trachea    NA   NA  VirginFemale Spermatheca    194.1   NA  InseminatedFemale Spermatheca    196   NA  Ovary    518.4   NA  Testis    214.6   NA  Male Accessory Gland    524.8   235.75  Carcass    106.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000032 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7899-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Acph-1n4 Acph-1n5 Acph-1n11 viable, with Scer\GAL4pnr-MD237 Acph-1GD558 Sterility Allele fertile Acph-1n4 Acph-1n5 Acph-1n11 Other Phenotypes Allele electrophoretic variant Acph-11.10 Acph-1B Acph-1F Acph-1n1 Acph-1n2 Acph-1n3 Acph-1n4 Acph-1n5 Acph-1n6 Acph-1n7 Acph-1n8 Acph-1n9 Acph-1n10 Acph-1n11 Acph-1n12 Acph-1n13 Acph-1n14 Acph-1n15 Acph-1S electrophoretic variant | fast Acph-1C Acph-1F electrophoretic variant | slow Acph-1A Acph-1cSa Phenotype manifest in Allele
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of Acph-1 Class Mutagen Stocks Known lesion Acph-1A spontaneous natural population 3 -- Acph-1B spontaneous natural population 3 -- Acph-1n13 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 2 -- Acph-1C spontaneous 1 -- Acph-1EY19501 P-element activity 1 -- Acph-1nGB1 loss of function allele spontaneous natural population 1 -- Acph-11.10 0 -- Acph-1F 0 -- Acph-1n10 loss of function allele ethyl methanesulfonate 0 -- Acph-1n11 loss of function allele ethyl methanesulfonate 0 -- Acph-1n12 loss of function allele ethyl methanesulfonate 0 -- Acph-1n14 loss of function allele ethyl methanesulfonate 0 -- Acph-1n15 loss of function allele ethyl methanesulfonate 0 -- Acph-1n1 loss of function allele ethyl methanesulfonate 0 -- Acph-1n2 loss of function allele ethyl methanesulfonate 0 -- Acph-1n3 loss of function allele ethyl methanesulfonate 0 -- Acph-1n4 loss of function allele ethyl methanesulfonate 0 -- Acph-1n5 loss of function allele ethyl methanesulfonate 0 -- Acph-1n6 loss of function allele ethyl methanesulfonate 0 -- Acph-1n7 loss of function allele ethyl methanesulfonate 0 -- Acph-1n8 loss of function allele ethyl methanesulfonate 0 -- Acph-1n9 loss of function allele ethyl methanesulfonate 0 -- Acph-1nGB2 loss of function allele spontaneous natural population 0 -- Acph-1nNC1 loss of function allele spontaneous natural population 0 -- Acph-1S 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Acph-1 Class Mutagen Stocks Known lesion Acph-1GD558 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Acph-1cSa in vitro construct - genomic fragment 0 Yes Acph-1cSb in vitro construct - genomic fragment 0 Yes Acph-1hs.PC in vitro construct - regulatory fusion 0 Yes Acph-1KK101995 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Acph-1tSa in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(3;1)B152 (Frisardi and MacIntyre, 1984) Dp(3;1)H163 (Harris, 1977) Dp(3;Y)L127 (Frisardi and MacIntyre, 1984)
Disrupted in	Df(3R)Exel6213 (Ryder, 2004.4.26) Dp(3;1)1A (Frisardi and MacIntyre, 1984) Dp(3;1)3 (Frisardi and MacIntyre, 1984) Dp(3;1)19 (Frisardi and MacIntyre, 1984) Dp(3;1)27 (Frisardi and MacIntyre, 1984) Dp(3;1)34 (Frisardi and MacIntyre, 1984) Dp(3;1)35 (Frisardi and MacIntyre, 1984) Dp(3;1)48 (Frisardi and MacIntyre, 1984) Dp(3;1)67A (Frisardi and MacIntyre, 1984) Dp(3;1)67N (Frisardi and MacIntyre, 1984) Dp(3;1)74 (Shaffer and MacIntyre, 1990) Dp(3;1)78 (Frisardi and MacIntyre, 1984, Shaffer and MacIntyre, 1990) Dp(3;1)79 (Frisardi and MacIntyre, 1984) Dp(3;1)88 (Frisardi and MacIntyre, 1984) Dp(3;1)93 (Frisardi and MacIntyre, 1984) Dp(3;1)97 (Frisardi and MacIntyre, 1984) Dp(3;1)124P (Frisardi and MacIntyre, 1984) Dp(3;1)138P (Frisardi and MacIntyre, 1984) Dp(3;1)150P (Frisardi and MacIntyre, 1984) Dp(3;1)152P (Frisardi and MacIntyre, 1984) Dp(3;1)R10 (Frisardi and MacIntyre, 1984) Dp(3;1)R14 (Frisardi and MacIntyre, 1984)
Not disrupted in	Dp(3;1)45B (Frisardi and MacIntyre, 1984) Dp(3;1)46A (Frisardi and MacIntyre, 1984) Dp(3;1)52 (Frisardi and MacIntyre, 1984, Shaffer and MacIntyre, 1990) Dp(3;1)74 (Frisardi and MacIntyre, 1984) Dp(3;1)165P (Frisardi and MacIntyre, 1984, Shaffer and MacIntyre, 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD558} NA P{KK101995} NA heat-shock construct P{Acpht-1} NA characterization construct P{Acph-1.A} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Acph-1EY19501 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
acid phosphatase activity inferred from sequence or structural similarity with UniProtKB:P11117 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Acph-1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71395 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000032 DroID - A comprehensive database of gene and protein interactions. • FBgn0000032 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48445
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16215 Dere\GG11981 Dgri\GH22183 Dmoj\GI21969 Dper\GL13492 Dpse\GA26867 Dsec\GM12199 Dsim\GD17508 Dvir\Acph Dwil\GK14084 Dyak\GE10406
Curated drosophilid orthologs	Dagu\Acph   Dalb\Acph   Dana\Acph   Dano\Acph   Daur\Acph (Triantaphyllidis, 1981) Dbii\Acph-1   Dbip\Acph (Parkash and Shamina, 1991) Dbus\Acph (Parkash and Shamina, 1991) Dbuz\Acph-1   Dele\Acph-1   Deug\Acph-1   Dfal\Acph   Dfor\Acph   Dgua\Acph-1   Dhyp\Acph   Dimm\Acph   Dlin\Acph   Dlit\Acph-1   Dmad\Acph-1   Dmat\Acph   Dmys\Acph   Dnag\Acph   Dnas\Acph   Dnen\Acph   Dprs\Acph-1   Dpse\Acph-1   Dqui\Acph   Drub\Acph   Dsan\Acph-1 (Lachaise et al., 2000) Dsec\Acph   Dsim\Acph-1 (MacIntyre, 1966) Dsub\Acph-1   Dtak\Acph   Dtei\Acph-1 (Lachaise et al., 2000) Dtrn\Acph   Dvir\Acph   Dyak\Acph-1   Zind\Acph-1   Zind\Acph-2
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003903-PA Aedes aegypti (mosquito) AGAP002387-PA Anopheles gambiae (mosquito) XP_624012.2 Apis mellifera (honey bee) XP_001949803.1 Acyrthosiphon pisum (pea aphid) 35999 Batrachochytrium dendrobatidis (chytrid fungus) 222050 Branchiostoma floridae (lancelet) XP_001896130.1 Brugia malayi (roundworm nematode) BGIBMGA003388-PA Bombyx mori (silk worm) ENSBTAP00000015451 Bos taurus (bovine) CN15350 Caenorhabditis brenneri (small nematode) CBP27529 Caenorhabditis briggsae (nematode) CE32100 Caenorhabditis elegans (worm) ENSCAFP00000009365 Canis familiaris (dog) ENSCINP00000008631 Ciona intestinalis (sea squirt) JA13284 Caenorhabditis japonica (nematode) CMT279C Cyanidioschyzon merolae (red alga) cgd4_910 Cryptosporidium parvum (protozoan parasite) cgd4_920 Cryptosporidium parvum (protozoan parasite) CPIJ004003 Culex pipens (mosquito) CPIJ016005 Culex pipens (mosquito) ENSCPOP00000012025 Cavia porcellus (guinea pig) RP43822 Caenorhabditis remanei (nematode) ENSCSAVP00000018709 Ciona savignyi (sedentary tunicate) 226537 Capitella spl (polychaete worm) DDB0302470 Dictyostelium discoideum (amoeba) 56978 Daphnia pulex (daphnia) ENSDARP00000009179 Danio rerio (zebra fish) ENSECAP00000011177 Equus caballus (horse) XP_649718 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018650 Gymnopilus aculeatus (mushroom) ENSGALP00000019020 Gallus gallus (chicken) GL50803_11599 Giardia lamblia (flagellated protozoan) GL50803_7556 Giardia lamblia (flagellated protozoan) 84756 Hypsipyla robusta (cedar shoot borer) ENSP00000323036 Homo sapiens (human) ISCW017166-PA Ixodes scapularis (deer tick) 139839 Lottia gigantea (owl limpet) LmjF23.1170 Leishmania major (virus) LmjF28.2650 Leishmania major (virus) LmjF36.2590 Leishmania major (virus) 33870 Monocosta brevicollis (choanoflagellate) ENSMODP00000032591 Monodelphis domestica (gray opossum) ENSMMUP00000020461 Macaca mulatta (rhesus monkey) ENSMUSP00000059889 Mus musculus (house mouse) 243021 Nematostella vectensis (starlet anemone) XP_001600994.1 Nasonia vitripennis (wasp) ENSOANP00000009999 Ornithorynchus anatinus (platypus) ENSORLP00000005038 Oryzias latipes (japanese killifish) PHUM000462-PA Pediculus humanus (human body louse) PP05312 Pristionchus pacificus (nematode) PP05917 Pristionchus pacificus (nematode) PP26766 Pristionchus pacificus (nematode) 162267 Physcomitrella patens (moss) ENSPPYP00000015780 Pongo pygmaeus (orangutan) ENSPTRP00000046525 Pan troglodytes (chimpanzee) ENSRNOP00000018620 Rattus norvegicus (norway rat) Smp_123670 Schistosoma mansoni (trematode parasite) XP_784807.2 Strongylocentrotus purpuratus (purple sea urchin) 22320 Trichoplax adhaerens (metazoa) XP_967434.1 Tribolium castaneum (red flour beetle) Tc00.1047053503431.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510181.100 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013252 Tetraodon nigroviridis (green spotted pufferfish) 24158 Thalassiosira pseudonana (marine diatom) ENSTRUP00000024188 Takifugu rubripes (pufferfish Takifugu) 3677.m00062 Tetrahymena thermophila (ciliate protozoa) 82343.m00175 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000008618 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19035 NV17912 LH22852 FBgn0228271 FBgn0216090 FBgn0023233 FBgn0189058 FBgn0167136 JGI_V11_56978 JGI_V11_251804 FBgn0248239 FBgn0151097 FBgn0144698 FBgn0129644 FBgn0104273 FBgn0093237 CPIJ016005 CPIJ004002 CPIJ004003 ACYPI008976 ACYPI008860 GB15862 AGAP002387 AAEL003915 AAEL003903 PHUM576780 GLEAN_15811
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	4012 Acph-1n13 22162 y1 w67c23; P{EPgy2}Acph-1EY19501 4016 Est-6S α-Est5F FdhS Lap-DF Acph-1A Tpi6/TM6, Est-6F α-Est5S FdhF Lap-DS Acph-1B Tpi4
Kyoto	101569 Acph-1B 101570 Acph-1C 101571 Acph-1n13 101286 Acph-1nGB1 / TM6, Acph-1A 107556 Est-6S α-Est5F FdhS Lap-DF Acph-1A Tpi6/TM6, Est-6F α-Est5S FdhF Lap-DS Acph-1B Tpi4
VDRC	v3579 w1118; P{GD558}v3579/TM3
Genomic Clones ( 1 )
	BACR07A18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 88 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE14694 RE40943
Other clones	DPiM_RE40943
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM01953 LD09416 LD14116 LD14791 LD15683 LD25672 LD32724 LD41284 LD42568 LD46574 LD47712 RE12903 RE14417 RE19429 RE19827 RE27662 RE29732 RE42468 RE46511 RE47280 RE47433 RE52178 RE54371 RE54940 RE63506 RE66678 RE73076 RH25837 RH33189 SD14243 SD23144
Other clones	33654 73653 74684 109186 CK01.168D.G4 Dmel_dig_020474_0681_1216 Dmel_neb_009058_0391_0857 Dmel_neb_012550_0400_3418 Dmel_neb_012843_0139_0821 Dmel_neb_013218_0436_3305 EC26949 EK103658 EK135607 EK204513 EK264051 FGH119F09 FGM303F04 IP14388 LD47943 RE01932 RP003008761 RP003069039 RP003082268 RP003086497 RP003094625 RP003095739 RP003110890 RP003111121 RP003124266 RP003180157 RP003203650 RP003206857 RP003220114 RP003225913 RP003249706 RP003272177 RP003284013 RP003293685 RP003303476 RP003355504 RP003386009 RP003448560 RP003449581 RP003454116 RP003458486 RP003481247 RP003502418 RP003511303 RP003523907 RP003538690 RP003549137 RP003626560 RP003627646 RP003652613
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000032 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48445
Antibody Information
Other Information
Discoverer
	MacIntyre, 1964.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Acph-1 CG7899 (Misra, 2000.7.28)
Additional comments
Other Comments
	Chromosome homologies of Muller's element D (J chromosome in the Paleartic species and XR chromosome arm in Nearctic species) and of element E (O chromosome in the Paleartic species and 2 chromosome in Nearctic species) have been confirmed by single copy probes in the species of the obscura group and in D.melanogaster. (Segarra et al., 1996) Comparisons between Acph-1 and Dsub\Acph-1 reveal that Acph-1 is a rather quickly evolving gene. (Navarro and Segarra, 1995) Gramoxone has no mutagenic effect on the genetic background of Acph-1. (el Abidin Salam et al., 1993) No difference in allele fixed in lines selected over 700 generations for high (negative) and low (positive) geotaxis. (Stoltenberg et al., 1992) Acph-1 is encoded by a 2.1 kb transcript which is constitutively expressed throughout development with peaks in early embryonic and early pupal stages. (Shaffer and MacIntyre, 1990) Acph-1 has been cloned and identified by transformation assays. (Shaffer and MacIntyre, 1990) Structural gene for acid phosphatase 1, the major phosphatase in adults; responsible for approximately 90% of the low-pH nucleotidase activity throughout development. Serves as a reliable cytochemical marker in many tissues (FBrf0033183). Enzyme appears to be produced in nurse cells and follicular cells of ovary and transferred to oocyte through the ring canals and by pinocytosis, respectively (FBrf0029963); maternally produced enzyme persists to third instar; paternal gene function detectable in gels after 9-10 hr of embryonic development (FBrf0031356); and after 5 hr histochemically (FBrf0031363). Enzyme found in larvae, pupae and adults; levels increase during adult life (FBrf0027302).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080178 NM_170453 RefSeq (Proteins) • NP_524917 NP_733332 DDBJ / EMBL / GenBank • AAF56981 AAL48699 AAN14203 AAN71396 AY071077 BI172347 BI243337 BT001641 Entrez Gene - A searchable database of RefSeq genes. • 48445 UniProtKB/TrEMBL • Q8I0P9 Q9VAD0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Histidine phosphatase superfamily, clade-2 (IPR000560)
Linkouts
	BioGRID - A database of protein and genetic interactions • 71395 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000032 DroID - A comprehensive database of gene and protein interactions. • FBgn0000032 DRSC - Results from RNAi screens. • FBgn0000032 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000032 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7899-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000032 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48445 InParanoid A subset of ortholog calls from InParanoid. • AAEL003903-PA Aedes aegypti (mosquito) AGAP002387-PA Anopheles gambiae (mosquito) XP_624012.2 Apis mellifera (honey bee) XP_001949803.1 Acyrthosiphon pisum (pea aphid) 35999 Batrachochytrium dendrobatidis (chytrid fungus) 222050 Branchiostoma floridae (lancelet) XP_001896130.1 Brugia malayi (roundworm nematode) BGIBMGA003388-PA Bombyx mori (silk worm) ENSBTAP00000015451 Bos taurus (bovine) CN15350 Caenorhabditis brenneri (small nematode) CBP27529 Caenorhabditis briggsae (nematode) CE32100 Caenorhabditis elegans (worm) ENSCAFP00000009365 Canis familiaris (dog) ENSCINP00000008631 Ciona intestinalis (sea squirt) JA13284 Caenorhabditis japonica (nematode) CMT279C Cyanidioschyzon merolae (red alga) cgd4_910 Cryptosporidium parvum (protozoan parasite) cgd4_920 Cryptosporidium parvum (protozoan parasite) CPIJ004003 Culex pipens (mosquito) CPIJ016005 Culex pipens (mosquito) ENSCPOP00000012025 Cavia porcellus (guinea pig) RP43822 Caenorhabditis remanei (nematode) ENSCSAVP00000018709 Ciona savignyi (sedentary tunicate) 226537 Capitella spl (polychaete worm) DDB0302470 Dictyostelium discoideum (amoeba) 56978 Daphnia pulex (daphnia) ENSDARP00000009179 Danio rerio (zebra fish) ENSECAP00000011177 Equus caballus (horse) XP_649718 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018650 Gymnopilus aculeatus (mushroom) ENSGALP00000019020 Gallus gallus (chicken) GL50803_11599 Giardia lamblia (flagellated protozoan) GL50803_7556 Giardia lamblia (flagellated protozoan) 84756 Hypsipyla robusta (cedar shoot borer) ENSP00000323036 Homo sapiens (human) ISCW017166-PA Ixodes scapularis (deer tick) 139839 Lottia gigantea (owl limpet) LmjF23.1170 Leishmania major (virus) LmjF28.2650 Leishmania major (virus) LmjF36.2590 Leishmania major (virus) 33870 Monocosta brevicollis (choanoflagellate) ENSMODP00000032591 Monodelphis domestica (gray opossum) ENSMMUP00000020461 Macaca mulatta (rhesus monkey) ENSMUSP00000059889 Mus musculus (house mouse) 243021 Nematostella vectensis (starlet anemone) XP_001600994.1 Nasonia vitripennis (wasp) ENSOANP00000009999 Ornithorynchus anatinus (platypus) ENSORLP00000005038 Oryzias latipes (japanese killifish) PHUM000462-PA Pediculus humanus (human body louse) PP05312 Pristionchus pacificus (nematode) PP05917 Pristionchus pacificus (nematode) PP26766 Pristionchus pacificus (nematode) 162267 Physcomitrella patens (moss) ENSPPYP00000015780 Pongo pygmaeus (orangutan) ENSPTRP00000046525 Pan troglodytes (chimpanzee) ENSRNOP00000018620 Rattus norvegicus (norway rat) Smp_123670 Schistosoma mansoni (trematode parasite) XP_784807.2 Strongylocentrotus purpuratus (purple sea urchin) 22320 Trichoplax adhaerens (metazoa) XP_967434.1 Tribolium castaneum (red flour beetle) Tc00.1047053503431.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510181.100 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013252 Tetraodon nigroviridis (green spotted pufferfish) 24158 Thalassiosira pseudonana (marine diatom) ENSTRUP00000024188 Takifugu rubripes (pufferfish Takifugu) 3677.m00062 Tetrahymena thermophila (ciliate protozoa) 82343.m00175 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000008618 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48445 modMine - Data generated by the modENCODE project. • FBgn0000032 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19035 NV17912 LH22852 FBgn0228271 FBgn0216090 FBgn0023233 FBgn0189058 FBgn0167136 JGI_V11_56978 JGI_V11_251804 FBgn0248239 FBgn0151097 FBgn0144698 FBgn0129644 FBgn0104273 FBgn0093237 CPIJ016005 CPIJ004002 CPIJ004003 ACYPI008976 ACYPI008860 GB15862 AGAP002387 AAEL003915 AAEL003903 PHUM576780 GLEAN_15811
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	ACP (Borlase et al., 1993) ACPH (Bondinas et al., 2002, Bondinas et al., 2001, Choudhary et al., 1992) Acph (Matthews and Munstermann, 1994, Bubli et al., 1996, Parkash et al., 1993, el Abidin Salam et al., 1993, Marinkovic et al., 1992, Parkash and Shamina, 1991, Ehiobu et al., 1990) Acph-1 (Wright, 1987, Kovac and Marinkovic, 1999) APH (Burnell et al., 1991) CG7899 (Arbeitman et al., 2004, Keleman et al., 2009.8.5, Cammarato et al., 2011)
Name Synonym	acid phosphatase (Kovac and Marinkovic, 1999) Acid phosphatase 1 (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0039729
References ( 65 )
Generate a list of	All references relating to this gene ( 65 )
List References by type	Research paper  ( 45 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers (0)
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Recent reviews (0)
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