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FB2025_05
,
released December 11, 2025
ALS, Dα1, nAcRalpha-96Aa, nAChR, nAcRα-96Aa
forms pentameric receptors involved in fast excitatory synaptic neurotransmission - associated with changes in courtship, sleep longevity and insecticide resistance
Please see the JBrowse view of Dmel\nAChRα1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
Stop-codon suppression (UAG) postulated; FBrf0216884.
Gene model reviewed during 5.56
The group(s) of polypeptides indicated below share identical sequence to each other.
nAcRα-96Aa protein appears to be the
ligand-binding subunit of the class I α-Btx binding complex.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nAChRα1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Transcript is detected in the larval fat body and in the clusters of cells in the pars intercerebralis corresponding to the medial neurosecretory cell clusters (m-NSCs) that express the insulin like protein genes.
JBrowse - Visual display of RNA-Seq signals
View Dmel\nAChRα1 in JBrowse3-85
3-83.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The distribution of nAcRα-96Aa protein in the developing and differentiated nervous system has been studied.
Antibodies raised against fusion constructs encompassing specific regions of the Acr64B and Acr96Aa proteins were used to investigate a potential association of these two polypeptides.
An alpha-like subunit that resemble ligand-binding subunits of vertebrate subunits.
Characterisation of toxin binding to the domain carrying the cholinergic binding sites of nAcRα-96Aa.
Structural gene encoding a Drosophila homologue of a subunit of vertebrate nicotinic acetylcholine receptors (nAChR); inferred to be homologous to neuronal α subunits based on the cystein doublet at amino-acid residues 201 and 202.
nAcRα-96Ab appears to be a chimeric gene, with the 5' part of the gene derived from nAcRα-96Aa and the 3' part of the gene derived from nAcRβ-64B.
"nAcRα-96Ab" is a putative chimeric gene derived from the "nAcRα-96Aa" and "nAcRβ-64B" genes (where coding sequences of the two parental genes contribute to the coding sequence of the chimeric gene).
Source for identity of: nAcRα-96Aa CG5610
Source for identity of: nAChRα1 nAcRα-96Aa
Renamed genes encoding nicotinic Acetylcholine Receptors to give systematic nomenclature that better reflects usage in literature (e.g. FBrf0218556, FBrf0183743).
