ARD, nAcRβ-64B, Dβ1, nAcRbeta-64B, nAChR
Gene model reviewed during 5.46
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nAChRβ1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\nAChRβ1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: nAChRβ1 nAcRβ-64B
Source for merge of: CG12606 CG11348
"nAcRα-96Ab" is a putative chimeric gene derived from the "nAcRα-96Aa" and "nAcRβ-64B" genes (where coding sequences of the two parental genes contribute to the coding sequence of the chimeric gene).
Source for merge of CG12606 CG11348 was a shared cDNA.
Ecol\lacZ reporter gene constructs demonstrate a 900bp genomic promoter fragment contains the essential information for correct temporal and spatial expression.
A potential non-alpha subunit.
Ecol\lacZ reporter gene constructs have been used to identify one region necessary for transcriptional regulation of this subunit. nAcRβ-64B encodes a structural homologue of vertebrate nicotinic acetylcholine receptors (nAChR). Fusion constructs containing regions of the nAcRβ-64B were used to investigate the relationship between the nAcRβ-64B gene product and α-bungarotoxin binding sites. Equilibrium binding and kinetic studies reveal two different high affinity binding sites for α-bungarotoxin in fly head membranes.
Excitatory nAcRβ-64B gene product is encoded by a superfamily of related genes.