FB2019_05, released Oct 15, 2019

Gene: Dmel\Act57B

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General Information
Symbol
Dmel\Act57B
Species
D. melanogaster
Name
Actin 57B
Annotation Symbol
CG10067
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000044
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Actin 57B (Act57B) is one of several actin genes in the Drosophila genome, and one of the few that encode myofibrillar actin. This essential gene is a transcriptional target of Mef2 and Cf2 and is expressed in all embryonic muscles and a subset of adult muscle. [Date last reviewed: 2018-09-06]
Other Summaries
Also Known As
actin, F-actin, Act57A, C
Key Links
Genomic Location
Cytogenetic map
57B5-57B5
Sequence location
2R:20,944,021..20,946,431 [+]
Recombination map
2-92
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the actin family. (P53501)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
ACTINS -
Actins are highly conserved eukaryotic filament-forming proteins that are major components of the cytoskeleton. Actin polymerisation is controlled by ATP binding and hydrolysis. Actins are involved in various cell processes including cell movement, muscle contraction, cell trafficking and mechanical support. (Adapted from PMID:21859859).
Protein Function (UniProtKB)
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
(UniProt, P53501)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Act57A
According to Fyrberg and Davidson, Act57A encodes the actin I protein isoform, which is the major actin species of larval intersegmental muscle; also encodes adult cephalic and abdominal muscle (Fyrberg, Mahaffy, Bond and Davidson, 1983, Cell 33: 115-33).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Act57B or the JBrowse view of Dmel\Act57B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.51
Gene model reviewed during 5.53
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Act57B-RA
FBtr0071519
NM_079076
1724
376
Additional Transcript Data and Comments
Reported size (kB)
2 (northern blot)
(Casal and Leptin, 1996)
1.85, 1.8 (northern blot)
(Tobin et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Act57B-PA
FBpp0071448
41.8
376
5.05
NP_523800
AAF46640
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Post Translational Modification
Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.
(UniProt, P53501)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Act57B using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (5 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
mitotic cytokinesis
inferred from mutant phenotype
(Eggert et al., 2004)
neuromuscular junction development, skeletal muscle fiber
inferred from mutant phenotype
(Blunk et al., 2014)
regulation of synapse organization
inferred from mutant phenotype
(Blunk et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
mitotic cytokinesis
inferred from biological aspect of ancestor with PANTHER:PTN002631617
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
actin cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000232995
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval somatic muscle
(Tobin et al., 1990)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval muscle system
(Tobin et al., 1990)
embryonic stage 5 -- 17
mesoderm
(Casal and Leptin, 1996)
embryonic stage 10 -- 13
visceral mesoderm
(Kelly et al., 2002)
embryonic stage 11 -- 12
somatic mesoderm
(Kelly et al., 2002)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
embryonic stage 11 -- 15
somatic muscle primordium
(Elgar et al., 2008)
embryonic stage 12 -- 14
visceral muscle primordium
(Kelly et al., 2002)
somatic muscle primordium
(Kelly et al., 2002)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
embryonic stage 14
mesoderm
(Cunha et al., 2010)
embryonic stage 15 -- 17
embryonic/larval visceral muscle
(Kelly et al., 2002)
embryonic/larval somatic muscle
(Kelly et al., 2002)
embryonic stage 16 -- 17
embryonic/larval heart
(Kelly et al., 2002)
larval stage
pharyngeal muscle
(Tobin et al., 1990)
embryonic/larval dorsal vessel
(Shah et al., 2011)
embryonic/larval hypodermal muscle
(Shah et al., 2011)
adult stage
adult dorsal vessel
(Shah et al., 2011)
hypodermal muscle of A1-7
(Shah et al., 2011)
hypodermal muscle of prothorax
(Shah et al., 2011)
hypodermal muscle of mesothorax
(Shah et al., 2011)
hypodermal muscle of metathorax
(Shah et al., 2011)
Additional Descriptive Data
Act57B is expressed in the dorsal vessel and body wall muscles in both larvae and adults.
(Shah et al., 2011)
Expression dependent on Mef2 levels.
(Elgar et al., 2008)
Expression is observed in mesodermal tissues starting in late embryonic stages.
(Casal and Leptin, 1996)
Act57B transcripts are most abundant in larval stages but are also found in embryos. They accumulate in the developing larval body wall musculature, first as segmentally arranged linear arrays and finally as square blocks of concentrated signal over the larval musculature. Labeling of the pharyngeal musculature is observed in embryos.
(Tobin et al., 1990)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
Reporter: P{Act57B-lacZ.-278+2}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
visceral mesoderm
(Kelly et al., 2002)
embryonic stage 16
embryonic/larval somatic muscle
(Kelly et al., 2002)
Reporter: P{Act57B-lacZ.-593+2.mMEF2}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
visceral mesoderm | faint
(Kelly et al., 2002)
embryonic stage 16
embryonic/larval somatic muscle | faint
(Kelly et al., 2002)
Reporter: P{Act57B-lacZ.-593+2}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
visceral mesoderm | intense
(Kelly et al., 2002)
embryonic stage 16
embryonic/larval somatic muscle | intense
(Kelly et al., 2002)
embryonic/larval heart
(Kelly et al., 2002)
adult stage
adult heart
(Shah et al., 2011)
Reporter: P{Act57B-lacZ.-1742+2}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
visceral mesoderm
(Kelly et al., 2002)
embryonic stage 16
embryonic/larval somatic muscle
(Kelly et al., 2002)
embryonic/larval heart
(Kelly et al., 2002)
Reporter: P{Act57B-lacZ.-2479+2}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10 -- 13
visceral mesoderm
(Kelly et al., 2002)
embryonic stage 11 -- 12
somatic mesoderm
(Kelly et al., 2002)
embryonic stage 12 -- 14
visceral muscle primordium
(Kelly et al., 2002)
somatic muscle primordium
(Kelly et al., 2002)
embryonic stage 15 -- 17
embryonic/larval visceral muscle
(Kelly et al., 2002)
embryonic/larval somatic muscle
(Kelly et al., 2002)
embryonic stage 16 -- 17
embryonic/larval heart
(Kelly et al., 2002)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Act57B in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Act57B
Transgenic constructs containing regulatory region of Act57B
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Mef2.PU
lethal (with Df(2R)Exel7166)
lethal - all die before end of larval stage (with Df(2R)E2)
lethal - all die before end of P-stage
lethal - all die before end of P-stage (with Df(2R)Exel7166)
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4Mef2.PR
Other Phenotypes
Allele
flight defective, with Scer\GAL4Mef2.PR
flightless, with Scer\GAL4Act88F.PB
flightless, with Scer\GAL4Mef2.PR
locomotor behavior defective, with Scer\GAL4Mef2.PR
locomotor behavior defective | third instar larval stage
majority die during P-stage, with Scer\GAL4Mef2.PR
mitotic cell cycle defective, with Scer\GAL4VP16.nos.UTR
neuroanatomy defective | third instar larval stage
neuroanatomy defective | third instar larval stage (with Df(2R)Exel7166)
neurophysiology defective | third instar larval stage
neurophysiology defective | third instar larval stage (with Df(2R)Exel7166)
small body | third instar larval stage
some die during larval stage (with Df(2R)E2)
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Mef2.PR
Phenotype manifest in
Allele
adult heart, with Scer\GAL4Hand.PU
cortical actin cytoskeleton
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage (with Df(2R)Exel7166)
germline cyst, with Scer\GAL4VP16.nos.UTR
indirect flight muscle, with Scer\GAL4Act88F.PB
indirect flight muscle, with Scer\GAL4Mef2.PR
indirect flight muscle | progressive, with Scer\GAL4Act88F.PB
ionotropic glutamate receptor complex | third instar larval stage
NMJ bouton
presynaptic active zone | third instar larval stage
presynaptic active zone | third instar larval stage (with Df(2R)Exel7166)
sarcomere, with Scer\GAL4Mef2.PR
spectrin-associated cytoskeleton | third instar larval stage
subsynaptic reticulum
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (29)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ACTB
8 of 15
No
Yes
 
Hsap\ACTG1
7 of 15
No
No
Hsap\ACTBL2
5 of 15
No
Yes
Hsap\ACTA1
4 of 15
Yes
No
Hsap\ACTA2
4 of 15
No
No
Hsap\ACTC1
4 of 15
Yes
No
 
Hsap\ACTG2
4 of 15
No
No
Hsap\POTEF
4 of 15
No
No
Hsap\POTEI
4 of 15
No
No
Hsap\POTEJ
4 of 15
No
Yes
Hsap\POTEE
3 of 15
No
No
Hsap\ACTR1A
2 of 15
No
No
 
Hsap\ACTR1B
2 of 15
No
No
 
Hsap\ACTRT1
2 of 15
No
No
Hsap\ACTRT2
2 of 15
No
No
Hsap\ACTRT3
2 of 15
No
Yes
Hsap\ACTL7A
1 of 15
Yes
No
Hsap\ACTL7B
1 of 15
Yes
No
Hsap\ACTL8
1 of 15
No
No
Hsap\ACTL9
1 of 15
No
Yes
Hsap\ACTL10
1 of 15
No
Yes
Hsap\ACTR10
1 of 15
No
No
Hsap\POTEA
1 of 15
No
Yes
Hsap\POTEB2
1 of 15
No
Yes
Hsap\POTEB
1 of 15
No
Yes
Hsap\POTEC
1 of 15
No
Yes
Hsap\POTED
1 of 15
No
Yes
Hsap\POTEG
1 of 15
No
Yes
Hsap\POTEH
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Actb
9 of 15
No
Yes
Mmus\Actg1
6 of 15
No
No
Mmus\Actbl2
5 of 15
No
Yes
Mmus\Acta1
4 of 15
Yes
No
Mmus\Acta2
4 of 15
No
No
Mmus\Actc1
4 of 15
Yes
No
Mmus\Actg2
4 of 15
No
No
Mmus\Actr1b
2 of 15
No
No
Mmus\Actrt1
2 of 15
No
No
Mmus\Actrt2
2 of 15
No
No
Mmus\Actrt3
2 of 15
No
Yes
Mmus\Actl7a
1 of 15
Yes
No
Mmus\Actl7b
1 of 15
Yes
No
Mmus\Actl9
1 of 15
No
Yes
Mmus\Actl10
1 of 15
No
Yes
Mmus\Actl11
1 of 15
No
Yes
Mmus\Actr1a
1 of 15
No
No
Mmus\Actr10
1 of 15
No
No
Mmus\LOC102636989
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (22)
Rnor\Actb
8 of 13
Yes
No
Rnor\Actg1
6 of 13
No
No
Rnor\Acta1
4 of 13
Yes
No
Rnor\Actbl2
4 of 13
No
Yes
Rnor\Actc1
4 of 13
Yes
No
Rnor\Actg2
3 of 13
No
No
Rnor\Acta2
2 of 13
No
Yes
Rnor\Actr1a
2 of 13
No
No
Rnor\Actr1b
2 of 13
No
No
Rnor\Actrt1
2 of 13
No
No
Rnor\Actrt2
2 of 13
No
No
Rnor\Actrt3
2 of 13
No
Yes
Rnor\Actl7a
1 of 13
No
Yes
Rnor\Actl7b
1 of 13
No
Yes
Rnor\Actl9b
1 of 13
No
Yes
Rnor\Actl9
1 of 13
No
Yes
Rnor\Actl10
1 of 13
No
Yes
Rnor\Actl11
1 of 13
No
Yes
Rnor\Actr10
1 of 13
No
No
Rnor\LOC100361457
1 of 13
No
No
Rnor\LOC102552318
1 of 13
No
No
Rnor\Potef
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\actb
6 of 12
Yes
No
Xtro\actg1
4 of 12
No
No
Xtro\acta1
3 of 12
No
Yes
Xtro\acta2
3 of 12
No
No
Xtro\act3
2 of 12
No
Yes
Xtro\actc1
2 of 12
No
Yes
Xtro\actr1a
2 of 12
No
No
Xtro\actr10
1 of 12
No
No
Xtro\ankrd52
1 of 12
No
Yes
Xtro\MGC75582
1 of 12
No
Yes
Danio rerio (Zebrafish) (14)
Drer\actb1
7 of 15
Yes
No
Drer\actb2
6 of 15
No
No
Drer\acta1b
4 of 15
No
Yes
Drer\acta2
4 of 15
No
No
Drer\actc1b
4 of 15
No
Yes
Drer\actc1c
4 of 15
No
No
Drer\si:ch73-187m15.4
4 of 15
No
Yes
Drer\zgc:86709
4 of 15
No
Yes
Drer\acta1a
3 of 15
No
Yes
Drer\actc1a
3 of 15
No
Yes
Drer\actr1
2 of 15
No
No
Drer\si:ch211-241j12.3
2 of 15
No
No
Drer\actr10
1 of 15
No
No
Drer\ankrd52b
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\act-4
8 of 15
Yes
No
Cele\act-1
6 of 15
No
No
Cele\act-2
6 of 15
No
No
Cele\act-3
3 of 15
No
No
Cele\act-5
3 of 15
No
No
Cele\arp-1
1 of 15
No
No
Cele\arp-11
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\ACT8
8 of 9
Yes
No
Atha\ACT12
8 of 9
Yes
No
Atha\ACT2
7 of 9
No
No
Atha\ACT4
7 of 9
No
No
Atha\ACT7
7 of 9
No
Yes
Atha\ACT11
7 of 9
No
No
Atha\ACT3
6 of 9
No
No
Atha\ACT9
3 of 9
No
Yes
Atha\AT2G42100
3 of 9
No
Yes
Atha\ACT1
2 of 9
No
No
Atha\AT2G42170
2 of 9
No
Yes
Atha\ARP7
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\ACT1
12 of 15
Yes
No
 
Scer\ARP1
3 of 15
No
No
Scer\ARP9
2 of 15
No
Yes
Scer\ARP4
1 of 15
No
No
Scer\ARP10
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\act1
9 of 12
Yes
No
Spom\arp9
1 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091909BS )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Act87E
Drosophila melanogaster
fruit fly
Dmel\Act57B
Drosophila melanogaster
fruit fly
Dmel\Act88F
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002723
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012948
Drosophila simulans
Dsim\GD11548
Drosophila simulans
Dsim\GD18909
Drosophila simulans
Dsim\GD15015
Drosophila simulans
Dsim\Act88F
Drosophila sechellia
Dsec\GM24109
Drosophila sechellia
Dsec\GM15786
Drosophila erecta
Dere\GG22068
Drosophila erecta
Dere\GG19688
Drosophila yakuba
Dyak\GE24312
Drosophila yakuba
Dyak\GE12149
Drosophila yakuba
Dyak\GE26273
Drosophila ananassae
Dana\GF12208
Drosophila ananassae
Dana\GF17602
Drosophila pseudoobscura pseudoobscura
Dpse\GA26730
Drosophila pseudoobscura pseudoobscura
Dpse\GA14877
Drosophila pseudoobscura pseudoobscura
Dpse\GA24346
Drosophila persimilis
Dper\GL17061
Drosophila willistoni
Dwil\GK13943
Drosophila willistoni
Dwil\GK23336
Drosophila virilis
Dvir\ActE1
Drosophila virilis
Dvir\ActC2
Drosophila virilis
Dvir\ActE2
Drosophila mojavensis
Dmoj\GI19711
Drosophila mojavensis
Dmoj\GI24339
Drosophila mojavensis
Dmoj\GI23222
Drosophila grimshawi
Dgri\GH22007
Drosophila grimshawi
Dgri\GH19077
Drosophila grimshawi
Dgri\GH19045
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915055R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010212
Glossina morsitans
Tsetse fly
Gmor\GMOY007085
Glossina morsitans
Tsetse fly
Gmor\GMOY003315
Glossina morsitans
Tsetse fly
Gmor\GMOY001776
Glossina morsitans
Tsetse fly
Gmor\GMOY008458
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13954
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12755
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07652
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04907
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12850
Mayetiola destructor
Hessian fly
Mdes\Mdes000529
Mayetiola destructor
Hessian fly
Mdes\Mdes011542
Mayetiola destructor
Hessian fly
Mdes\Mdes016052
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011197
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005961
Aedes aegypti
Yellow fever mosquito
Aaeg\ACT-1
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004631
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001673
Anopheles gambiae
Malaria mosquito
Agam\Actin5C
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016462
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009808
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005785
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012573
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05GN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA013945
Bombyx mori
Silkmoth
Bmor\BGIBMGA012151
Danaus plexippus
Monarch butterfly
Dple\DPOGS200327-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215022-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200328-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207542-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008719
Heliconius melpomene
Postman butterfly
Hmel\HMEL014820
Heliconius melpomene
Postman butterfly
Hmel\HMEL002915
Heliconius melpomene
Postman butterfly
Hmel\HMEL002914
Heliconius melpomene
Postman butterfly
Hmel\HMEL013620
Apis florea
Little honeybee
Aflo\2535574084
Apis florea
Little honeybee
Aflo\2147496403
Apis florea
Little honeybee
Aflo\2156442452
Apis florea
Little honeybee
Aflo\3091244148
Apis florea
Little honeybee
Aflo\2156441956
Apis florea
Little honeybee
Aflo\2147485905
Apis mellifera
Western honey bee
Amel\Arp1
Apis mellifera
Western honey bee
Amel\LOC552637
Apis mellifera
Western honey bee
Amel\GB43029
Apis mellifera
Western honey bee
Amel\GB41311
Apis mellifera
Western honey bee
Amel\LOC410075
Apis mellifera
Western honey bee
Amel\GB41310
Apis mellifera
Western honey bee
Amel\LOC410075
Apis mellifera
Western honey bee
Amel\LOC551438
Apis mellifera
Western honey bee
Amel\LOC725739
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13080
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19570
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13081
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13079
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15677
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10263
Bombus terrestris
Buff-tailed bumblebee
Bter\15207699
Bombus terrestris
Buff-tailed bumblebee
Bter\15207700
Bombus terrestris
Buff-tailed bumblebee
Bter\15209939
Bombus terrestris
Buff-tailed bumblebee
Bter\15210885
Bombus terrestris
Buff-tailed bumblebee
Bter\15212932
Bombus terrestris
Buff-tailed bumblebee
Bter\15207702
Linepithema humile
Argentine ant
Lhum\LH18449
Linepithema humile
Argentine ant
Lhum\LH23517
Linepithema humile
Argentine ant
Lhum\LH20482
Linepithema humile
Argentine ant
Lhum\LH23521
Linepithema humile
Argentine ant
Lhum\LH12777
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00025b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016133
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014261
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022374
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018151
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG030216
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00495
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05577
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06799
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03840
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07087
Tribolium castaneum
Red flour beetle
Tcas\TC030579
Tribolium castaneum
Red flour beetle
Tcas\TC003326
Pediculus humanus
Human body louse
Phum\PHUM515240
Pediculus humanus
Human body louse
Phum\PHUM268330
Rhodnius prolixus
Kissing bug
Rpro\RPRC008015
Rhodnius prolixus
Kissing bug
Rpro\RPRC015176
Rhodnius prolixus
Kissing bug
Rpro\RPRC008338
Rhodnius prolixus
Kissing bug
Rpro\RPRC009322
Cimex lectularius
Bed bug
Clec\CLEC002502
Cimex lectularius
Bed bug
Clec\CLEC009650-PD
Cimex lectularius
Bed bug
Clec\CLEC009650
Cimex lectularius
Bed bug
Clec\CLEC009650-PC
Cimex lectularius
Bed bug
Clec\CLEC001484
Cimex lectularius
Bed bug
Clec\CLEC012439
Cimex lectularius
Bed bug
Clec\CLEC009650-PB
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI073036
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009912
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006251
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006969
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15719
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04969
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05049
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05427
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05CQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000111
Strigamia maritima
European centipede
Smar\SMAR006663
Strigamia maritima
European centipede
Smar\SMAR014889
Strigamia maritima
European centipede
Smar\SMAR004044
Ixodes scapularis
Black-legged tick
Isca\ISCW022123
Ixodes scapularis
Black-legged tick
Isca\ISCW024111
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77676.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61741.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71572.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77038.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71192.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g05360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09480
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g05350
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g09350
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_203872
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347739
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347740
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347736
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347742
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_228751
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08LD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Act
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CplcaIIIb
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Actb_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Actg1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Arp1/Centph
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CplcaIIb
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Act_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Msclact
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CskaIIa
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Actph6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CskaI
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Act_5
Ciona intestinalis
Vase tunicate
Cint\LOC100184134
Ciona intestinalis
Vase tunicate
Cint\LOC100183894
Ciona intestinalis
Vase tunicate
Cint\LOC100178468
Ciona intestinalis
Vase tunicate
Cint\LOC101243473
Ciona intestinalis
Vase tunicate
Cint\LOC100184579
Ciona intestinalis
Vase tunicate
Cint\LOC100181800
Ciona intestinalis
Vase tunicate
Cint\LOC100185562
Ciona intestinalis
Vase tunicate
Cint\act
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028749
Gallus gallus
Domestic chicken
Ggal\ACTR1A
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009621
Gallus gallus
Domestic chicken
Ggal\ACTBL2
Gallus gallus
Domestic chicken
Ggal\ACTC1
Gallus gallus
Domestic chicken
Ggal\ACTG2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001381
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000011086
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Act42A
8 of 10
Act87E
8 of 10
Act5C
7 of 10
Act79B
7 of 10
Act88F
7 of 10
Arp53D
5 of 10
Arp1
4 of 10
Arp10
2 of 10
Arp2
1 of 10
Arp3
1 of 10
Arp5
1 of 10
Arp6
1 of 10
Arp8
1 of 10
Bap55
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 7 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ACTB; actin beta
8 of 15
102630
 
ACTG1; actin gamma 1
7 of 15
102560
ACTBL2; actin beta like 2
5 of 15
614835
      ACTA1; actin alpha 1, skeletal muscle
      4 of 15
      102610
      ACTA2; actin alpha 2, smooth muscle
      4 of 15
      102620
      ACTC1; actin alpha cardiac muscle 1
      4 of 15
      102540
       
      ACTG2; actin gamma 2, smooth muscle
      4 of 15
      102545
      POTEF; POTE ankyrin domain family member F
      4 of 15
          POTEI; POTE ankyrin domain family member I
          4 of 15
              POTEJ; POTE ankyrin domain family member J
              4 of 15
                  POTEE; POTE ankyrin domain family member E
                  3 of 15
                  608914
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Interactions
                      Summary of Physical Interactions
                      esyN Network Diagram
                      Show neighbor-neighbor interactions:
                      Select Layout:
                      Legend:
                      Protein
                      RNA
                      Selected Interactor(s)
                      Interactions Browser
                      View in Interactions Browser
                      Please see the Physical Interaction reports below for full details
                      protein-protein
                      Physical Interaction
                      Assay
                      References
                      Act57B - Act42A
                      two hybrid
                      (Hu et al., 2017.6.13)
                      Act57B - Act79B
                      two hybrid
                      (Hu et al., 2017.6.13)
                      Act57B - Act88F
                      two hybrid
                      (Hu et al., 2017.6.13)
                      Act57B - Akt1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      Act57B - Arp2
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - Arp3
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - Arpc1
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - Arpc2
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - Arpc3A
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - Arpc4
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - CG10265
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - CG12206
                      two hybrid
                      (Hu et al., 2017.6.13)
                      Act57B - CG17124
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - CG31559
                      two hybrid
                      (Hu et al., 2017.6.13)
                      Act57B - Df31
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - Gip
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - Myc
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      Act57B - Pdk1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      Act57B - Rheb
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      Act57B - Sh3β
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - Swip-1
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - Tcs3
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - awd
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - capt
                      experimental knowledge based, two hybrid
                      (Hu et al., 2017.6.13, Guruharsha et al., 2011)
                      Act57B - cpa
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - cpb
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - cry
                      anti tag coimmunoprecipitation, Identification by mass spectrometry, two hybrid
                      (Schlichting et al., 2018)
                      Act57B - didum
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Act57B - osk
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Hurd et al., 2016)
                      Act57B - scra
                      anti tag coimmunoprecipitation, peptide massfingerprinting
                      (D'Avino et al., 2008)
                      Act57B - βTub85D
                      experimental knowledge based
                      (Guruharsha et al., 2011)
                      Summary of Genetic Interactions
                      esyN Network Diagram
                      esyN Network Key:
                      Suppression
                      Enhancement
                      View in Interactions Browser
                      Please look at the allele data for full details of the genetic interactions
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      Act57B
                      suppressible
                      Mhc
                      (Viswanathan et al., 2015)
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      External Data
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Pathways
                      Gene Group - Pathway Membership (FlyBase)
                      External Data
                      Linkouts
                      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      2R
                      Recombination map
                      2-92
                      Cytogenetic map
                      57B5-57B5
                      Sequence location
                      2R:20,944,021..20,946,431 [+]
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      57B5-57B5
                      Limits computationally determined from genome sequence between P{lacW}l(2)k06409k06409&P{PZ}insc05475 and P{PZ}l(2)0780607806
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      57A-57A
                      (determined by in situ hybridisation)
                      (Drosopoulou et al., 1997, Fyrberg et al., 1981)
                      57A-57C
                      (determined by in situ hybridisation)
                      (Meisen et al., 1988)
                      57B-57B
                      (determined by in situ hybridisation)
                      (Tobin et al., 1980)
                      Experimentally Determined Recombination Data
                      Location
                      2-92
                      (FlyBase, 2016)
                      2-94--99
                      (Blunk et al., 2014)
                      2-99.5
                      (Comeron et al., 2012)
                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (5)
                      Genomic Clones (20)
                      cDNA Clones (164)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequences
                      BDGP DGC clones
                      Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of
                      Source for database merge of
                      Source for merge of: Act57B anon- EST:CL2c12
                      (Bayraktaroglu, 2000.11.2)
                      Member gene of
                      Actin
                      (Goldstein and Gunawardena, 2000)
                      Additional comments
                      The Act5C gene may be derived from the Act57B gene by retroposition.
                      (Betran et al., 2002)
                      Other Comments
                      ChEST reveals this is a target of Mef2.
                      (Junion et al., 2005)
                      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.
                      (Eggert et al., 2004)
                      Age related changes in Act57B expression have been studied by Northern analysis.
                      (Labuhn and Brack, 1997)
                      Isolated from a subtractive cDNA library enriched in sequences expressed in the mesoderm.
                      (Casal and Leptin, 1996)
                      An Act57B cDNA has been cloned and sequenced. Act57B is expressed in the mesoderm.
                      (Casal and Leptin, 1996)
                      EST RE38067 is chimeric; the 5' portion (BI241073) matches part of AE003430 on the opposite strand to GlcAT-I, the 3' portion (CK133782) corresponds to part of Act57B.
                      (FlyBase, 1996-)
                      Sequence analysis demonstrates insect muscle actins form a distinct family of closely related proteins significantly diverged from cytoplasmic actins.
                      (Mounier et al., 1992)
                      Translation of actin RNA in early embryos injected with initiation factors has been studied.
                      (Hongo and Jacobs-Lorena, 1991)
                      Encodes the actin I protein isoform, which is the major actin species of larval intersegmental muscle and adult cephalic and abdominal muscle (FBrf0038990).
                      Origin and Etymology
                      Discoverer
                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 44 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      Other crossreferences
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                      modMine - A data warehouse for the modENCODE project
                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyMine - An integrated database for Drosophila genomics
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Synonyms and Secondary IDs (26)
                      Reported As
                      Symbol Synonym
                      ACT3
                      (Liu et al., 2018)
                      Act57
                      (Rees et al., 2011)
                      Act57A
                      (Mounier et al., 1992, Fyrberg et al., 1983)
                      Act57B
                      (Hu et al., 2017.6.13, Min et al., 2017, Viswanathan et al., 2017, Adame et al., 2016, Fear et al., 2016, Ogneva et al., 2016, Kollmar, 2015.9.15, Viswanathan et al., 2015, Williams et al., 2015, Ciglar et al., 2014, Palsson et al., 2014, Ghezzi et al., 2013, Johnson et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Taliaferro et al., 2013, Walker et al., 2013, Aoki et al., 2012, Bryantsev and Cripps, 2012, Japanese National Institute of Genetics, 2012.5.21, Cherbas et al., 2011, Friedman et al., 2011, Shah et al., 2011, Bahadorani et al., 2010, Kallappagoudar et al., 2010, Müller et al., 2010, Müller et al., 2010, Lovato et al., 2009, Tan et al., 2009, Bai et al., 2008, Elgar et al., 2008, Fisher et al., 2008, Tanaka et al., 2008, Weber et al., 2008, Beltran et al., 2007, Gwack et al., 2007, Stuart et al., 2007, Dorus et al., 2006, Montana and Littleton, 2006, Ni et al., 2006, Sandmann et al., 2006, Stanyon et al., 2004)
                      Act57b
                      (Akimana et al., 2010, Earl and Britt, 2006)
                      Actin
                      (Schuettengruber et al., 2011, Clapier and Cairns, 2009, Balasubramanian et al., 2004, Eberharter and Becker, 2004, Jones, 1999, Hongo and Jacobs-Lorena, 1991)
                      Actin 57B
                      (Wójtowicz et al., 2015, Ibrahim et al., 2013)
                      ArpE
                      (Kollmar and Odronitz, 2006)
                      BEST:RE38067
                      C
                      (Bondinas et al., 2002, Bondinas et al., 2001)
                      CG10067
                      (Çiçek et al., 2016, Hurd et al., 2016, Aradska et al., 2015, Rosa-Ferreira et al., 2015, Ibrahim et al., 2013, Jensen et al., 2013, Schertel et al., 2013, Aoki et al., 2012, Jaspers et al., 2012, Cammarato et al., 2011, Müller et al., 2010, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2008, Weber et al., 2008, Derré et al., 2007, Bandyopadhyay et al., 2006, Fakhouri et al., 2006, Vierstraete et al., 2004, Vierstraete et al., 2003, Goldstein and Gunawardena, 2000)
                      CG30294
                      (Vierstraete et al., 2003)
                      M
                      (Casal and Leptin, 1996)
                      T10
                      (Vierstraete et al., 2004)
                      act 57A
                      (Labuhn and Brack, 1997)
                      act57A
                      (He and Haymer, 1995)
                      act57B
                      (Li et al., 2018, Bulchand et al., 2010, Deng et al., 2009)
                      act57b
                      (Buchon et al., 2009)
                      actin
                      (Eltsov et al., 2015, Rui et al., 2010, Padash Barmchi et al., 2005, Delmas et al., 2004, Kwon and Scholey, 2004, Strickland and Burgess, 2004, Xia and Karin, 2004, Jacinto and Baum, 2003, Miller, 2003, Baum, 2002, Biggin, 2001, Adams et al., 2000, Noselli and Agnes, 1999, Bearer, 1991)
                      actin-57B
                      (Kwiatkowski et al., 2018)
                      anon-EST:CL2c12
                      chr2R:16452771..16452966
                      (Will et al., 2013)
                      Name Synonyms
                      Actin
                      (Griemert et al., 2007, Mulinari et al., 2007, Jaiswal et al., 2006)
                      Actin 57B
                      (Williams et al., 2015, Blunk et al., 2014, Jaspers et al., 2012, Cammarato et al., 2011, D'Avino et al., 2008, Fakhouri et al., 2006, Sandmann et al., 2006)
                      Actin57B
                      (Viswanathan et al., 2015, Bryantsev et al., 2008, Tanaka et al., 2008, Ni et al., 2006)
                      F-actin
                      (Kang et al., 2017, Roubinet et al., 2017, Huang et al., 2016, Xu et al., 2011)
                      actin
                      (Davis et al., 2015, Jaiswal et al., 2013, Lenartowska et al., 2012, Bai et al., 2007, Costantino et al., 2007, Lo, 2006, Sordella and Van, 2006, Harris and Peifer, 2004, Zeitler et al., 2004, Baehrecke, 2003)
                      actin 57B
                      (Wang et al., 2014, Winbush et al., 2012, Texada et al., 2011, García-Zaragoza et al., 2008, Borghese et al., 2006)
                      actin57B
                      (Cunha et al., 2010, Deng et al., 2009, Bai et al., 2007)
                      Secondary FlyBase IDs
                      • FBgn0019861
                      • FBgn0050294
                      • FBgn0065030
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (203)