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Gene Dmel\Act79B

General Information
Symbol	Dmel\Act79B	Species	D. melanogaster
Name	Actin 79B	Annotation symbol	CG7478
Feature type	protein_coding_gene	FlyBase ID	FBgn0000045
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	Actin, D
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	79A6-79A6	Sequence location	3L:21,978,331..21,980,290 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Actin 79B is referred to in FlyBase by the symbol Dmel\Act79B (CG7478, FBgn0000045). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of cytoskeleton. Based on sequence similarity, it is predicted to be involved in the biological process: cytoskeleton organization. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Actin, conserved site; Actin-like; Actin/actin-like conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1624830_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Act79B. Gene sequence location is 3L:21978331..21980290.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Act79B According to Zulauf et al. (1981), Act79B appears to code for actin I, a larval muscle-specific actin. Initial translation product, which migrates as actin II, apparently acetylated to become actin I. Using probe from 3' transcribed-but-not-translated sequences, S'nchez et al. demonstrated two minor peaks of transcription during embryogenesis and major peaks during first and second instar and to a lesser degree in the pupa. Fyrberg, Mahaffy, Bond, and Davidson, (1983, Cell 33: 115-23) on the other hand, find Act79B to be expressed in adult legs and tubular muscles of thorax, including direct flight muscles, pleurosternal muscles, and muscles of various leg segments. In addition, Act79B is expressed in muscles that support the head and abdomen, in the scutellar pulsatile organ, and in two pairs of abdominal muscles that are present only in male flies (Courchesne-Smith, and Tobin, 1989, Dev. Biol. 133: 313-21). One of three actin genes expressed in wing development each with its characteristic developmental profile; peak activity at 80h of pupal age (Petersen, Bond, Mitchell, and Davidson, 1985, Dev. Genet. 5: 219-25.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN32081 HFA11604
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 79A6-79A6   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 79B-79B   (determined by in situ hybridisation)   (Drosopoulou et al., 1997) 79B-79B   (determined by in situ hybridisation)   (Zulauf et al., 1981) 79B-79B   (determined by in situ hybridisation)   (Fyrberg et al., 1981)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Act79B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Act79B-RA FBtr0078478  NM_079486   1522   376
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Act79B-PA   FBpp0078131   41.8   376   5.16     NP_524210   AAF51800
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin/actin-like conserved site (IPR020902) Actin-like (IPR004000) Actin, conserved site (IPR004001)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567848   AA698855   AA736180   AE014296 AAF51800   AI062255   AI064220   AI389587   AI404878   AK253228   AK283278   AK283429   AK283785   AY089535   AY089562   AY089587   AY113405   AY118735 AAM50595   AY118907   AY231646   AY432896   AY432900   AY432905   AY433196   AY439575   AY440361   AY440363   AY440778   AY572863   AY829794   BI631385   BT016152   BT050557   BT099500   BT099815   BX005750   BX006108   BX006205   BX006494   BX006851   BX007025   BX007169   BX009354   BX010404   BX011235   BX011682   BX012748   BX013090   BX014410   BX018008   BX019651   BX019681   BX021090   BX023258   BX023415   BX024085   BX025217   BX025942   BX026031   BX029573   BX029953   BX030198   BX031756   BX031960   BX032642   BX033057   BX033114   BX033742   BX034035   BX034514   BX034688   BX039747   BX042631   BX043104   BX046180   BX047639   BX050017   BX056209   BX063031   BX067175   CB305211   CO265353   CO270809   CO298532   CO328816   CO330107   CO342546   CR938056   CR938667   DQ440059   DQ507302   DQ507341   DQ675553   EC059815   EC067631   EC072809   EC073074   EC075488   EC076737   EC083904   EC209590   EC216303   EC225304   EC236983   EC241199   EC250860   EF092069   EF092073   EF207985   ES688632   ES690409   ES690420   ES691610   EV593934   EV599659   HM449853   HM449854   M18827 AAA28317   M18828 AAA28317   M18829 AAA28318
UniProtKB/Swiss-Prot	P02574
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000045    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000045 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000045 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr    235 embryo 16-18hr    222 embryo 18-20hr    369 embryo 20-22hr    121 embryo 22-24hr    148 larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new    915 white prepupae 12hr    6103 white prepupae 24hr    4359 pupae 2d postWPP    40167 pupae 3d postWPP    307670 pupae 4d postWPP    561609 adult male 01day    291704 adult male 05day    71265 adult male 30day    22323 adult female 01day    222127 adult female 05day    5813 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr  (235) embryo 16-18hr  (222) embryo 18-20hr  (369) embryo 20-22hr  (121) embryo 22-24hr  (148) larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new  (915) white prepupae 12hr  (6103) white prepupae 24hr  (4359) pupae 2d postWPP  (40167) pupae 3d postWPP  (307670) pupae 4d postWPP  (561609) adult male 01day  (291704) adult male 05day  (71265) adult male 30day  (22323) adult female 01day  (222127) adult female 05day  (5813) adult female 30day  (2943) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr    235 embryo 16-18hr    222 embryo 18-20hr    369 embryo 20-22hr    121 embryo 22-24hr    148 larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new    915 white prepupae 12hr  (6103) white prepupae 24hr  (4359) pupae 2d postWPP  (40167) pupae 3d postWPP  (307670) pupae 4d postWPP  (561609) adult male 01day  (291704) adult male 05day  (71265) adult male 30day  (22323) adult female 01day  (222127) adult female 05day  (5813) adult female 30day  (2943) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr    235 embryo 16-18hr    222 embryo 18-20hr    369 embryo 20-22hr    121 embryo 22-24hr    148 larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new    915 white prepupae 12hr    6103 white prepupae 24hr    4359 pupae 2d postWPP  (40167) pupae 3d postWPP  (307670) pupae 4d postWPP  (561609) adult male 01day  (291704) adult male 05day  (71265) adult male 30day  (22323) adult female 01day  (222127) adult female 05day    5813 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr    235 embryo 16-18hr    222 embryo 18-20hr    369 embryo 20-22hr    121 embryo 22-24hr    148 larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new    915 white prepupae 12hr    6103 white prepupae 24hr    4359 pupae 2d postWPP    40167 pupae 3d postWPP    307670 pupae 4d postWPP    561609 adult male 01day    291704 adult male 05day    71265 adult male 30day    22323 adult female 01day    222127 adult female 05day    5813 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000045 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr    235 embryo 16-18hr    222 embryo 18-20hr    369 embryo 20-22hr    121 embryo 22-24hr    148 larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new    915 white prepupae 12hr    6103 white prepupae 24hr    4359 pupae 2d postWPP    40167 pupae 3d postWPP    307670 pupae 4d postWPP    561609 adult male 01day    291704 adult male 05day    71265 adult male 30day    22323 adult female 01day    222127 adult female 05day    5813 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr  (235) embryo 16-18hr  (222) embryo 18-20hr  (369) embryo 20-22hr  121 embryo 22-24hr  (148) larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new  (915) white prepupae 12hr  (6103) white prepupae 24hr  (4359) pupae 2d postWPP  (40167) pupae 3d postWPP  (307670) pupae 4d postWPP  (561609) adult male 01day  (291704) adult male 05day  (71265) adult male 30day  (22323) adult female 01day  (222127) adult female 05day  (5813) adult female 30day  (2943) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr    235 embryo 16-18hr    222 embryo 18-20hr    369 embryo 20-22hr    121 embryo 22-24hr    148 larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new    915 white prepupae 12hr  (6103) white prepupae 24hr  (4359) pupae 2d postWPP  (40167) pupae 3d postWPP  (307670) pupae 4d postWPP  (561609) adult male 01day  (291704) adult male 05day  (71265) adult male 30day  (22323) adult female 01day  (222127) adult female 05day  (5813) adult female 30day  (2943) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr    235 embryo 16-18hr    222 embryo 18-20hr    369 embryo 20-22hr    121 embryo 22-24hr    148 larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new    915 white prepupae 12hr    6103 white prepupae 24hr    4359 pupae 2d postWPP  (40167) pupae 3d postWPP  (307670) pupae 4d postWPP  (561609) adult male 01day  (291704) adult male 05day  (71265) adult male 30day  (22323) adult female 01day  (222127) adult female 05day    5813 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    10 embryo 08-10hr    24 embryo 10-12hr    55 embryo 12-14hr    60 embryo 14-16hr    235 embryo 16-18hr    222 embryo 18-20hr    369 embryo 20-22hr    121 embryo 22-24hr    148 larva L1    68 larva L2    22 larva L3 12hr old    52 larva L3 puffstage 1-2    40 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    72 white prepupae new    915 white prepupae 12hr    6103 white prepupae 24hr    4359 pupae 2d postWPP    40167 pupae 3d postWPP    307670 pupae 4d postWPP    561609 adult male 01day    291704 adult male 05day    71265 adult male 30day    22323 adult female 01day    222127 adult female 05day    5813 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000045    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000045 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000045 expression level Tissue   Expression Level Larval Central Nervous System    9.7 Larval Midgut    24.7 Larval Hindgut no informative data Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.425 Larval Carcass no informative data Adult Head    217.8 Adult Eye no informative data Adult Brain    220.3 Adult Thoracic-Abdominal Ganglion    152.3 Adult Crop no informative data Adult Midgut    22.9 Adult Hindgut    22.1 Adult Malpighian Tubules no informative data Adult Fat Body    66.2 Adult Salivary Gland    21.1 Adult Heart    17.525 Adult VirginFemale Spermatheca    18.3 Adult InseminatedFemale Spermatheca    16.1 Adult Ovary    5.5 Adult Testis    11.5 Adult Male Accessory Gland    16.2 Adult Carcass    4318.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    9.7 Larval Midgut    24.7 Larval Hindgut no informative data Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.425 Larval Carcass no informative data Adult Head    217.8 Adult Eye no informative data Adult Brain    220.3 Adult Thoracic-Abdominal Ganglion    152.3 Adult Crop no informative data Adult Midgut    22.9 Adult Hindgut    22.1 Adult Malpighian Tubules no informative data Adult Fat Body    66.2 Adult Salivary Gland    21.1 Adult Heart    17.525 Adult VirginFemale Spermatheca    18.3 Adult InseminatedFemale Spermatheca    16.1 Adult Ovary    5.5 Adult Testis    11.5 Adult Male Accessory Gland    16.2 Adult Carcass  (4318.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    9.7 Larval Midgut    24.7 Larval Hindgut no informative data Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.425 Larval Carcass no informative data Adult Head    217.8 Adult Eye no informative data Adult Brain    220.3 Adult Thoracic-Abdominal Ganglion    152.3 Adult Crop no informative data Adult Midgut    22.9 Adult Hindgut    22.1 Adult Malpighian Tubules no informative data Adult Fat Body    66.2 Adult Salivary Gland    21.1 Adult Heart    17.525 Adult VirginFemale Spermatheca    18.3 Adult InseminatedFemale Spermatheca    16.1 Adult Ovary    5.5 Adult Testis    11.5 Adult Male Accessory Gland    16.2 Adult Carcass  (4318.8) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    9.7 Larval Midgut    24.7 Larval Hindgut no informative data Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.425 Larval Carcass no informative data Adult Head    217.8 Adult Eye no informative data Adult Brain    220.3 Adult Thoracic-Abdominal Ganglion    152.3 Adult Crop no informative data Adult Midgut    22.9 Adult Hindgut    22.1 Adult Malpighian Tubules no informative data Adult Fat Body    66.2 Adult Salivary Gland    21.1 Adult Heart    17.525 Adult VirginFemale Spermatheca    18.3 Adult InseminatedFemale Spermatheca    16.1 Adult Ovary    5.5 Adult Testis    11.5 Adult Male Accessory Gland    16.2 Adult Carcass    4318.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000045 expression level Tissue   Expression Level Larval Central Nervous System    9.7 Larval Midgut    24.7 Larval Hindgut no informative data Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.425 Larval Carcass no informative data Adult Head    217.8 Adult Eye no informative data Adult Brain    220.3 Adult Thoracic-Abdominal Ganglion    152.3 Adult Crop no informative data Adult Midgut    22.9 Adult Hindgut    22.1 Adult Malpighian Tubules no informative data Adult Fat Body    66.2 Adult Salivary Gland    21.1 Adult Heart    17.525 Adult VirginFemale Spermatheca    18.3 Adult InseminatedFemale Spermatheca    16.1 Adult Ovary    5.5 Adult Testis    11.5 Adult Male Accessory Gland    16.2 Adult Carcass    4318.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    9.7 Larval Midgut    24.7 Larval Hindgut no informative data Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.425 Larval Carcass no informative data Adult Head    217.8 Adult Eye no informative data Adult Brain    220.3 Adult Thoracic-Abdominal Ganglion    152.3 Adult Crop no informative data Adult Midgut    22.9 Adult Hindgut    22.1 Adult Malpighian Tubules no informative data Adult Fat Body    66.2 Adult Salivary Gland    21.1 Adult Heart    17.525 Adult VirginFemale Spermatheca    18.3 Adult InseminatedFemale Spermatheca    16.1 Adult Ovary    5.5 Adult Testis    11.5 Adult Male Accessory Gland    16.2 Adult Carcass  (4318.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    9.7 Larval Midgut    24.7 Larval Hindgut no informative data Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.425 Larval Carcass no informative data Adult Head    217.8 Adult Eye no informative data Adult Brain    220.3 Adult Thoracic-Abdominal Ganglion    152.3 Adult Crop no informative data Adult Midgut    22.9 Adult Hindgut    22.1 Adult Malpighian Tubules no informative data Adult Fat Body    66.2 Adult Salivary Gland    21.1 Adult Heart    17.525 Adult VirginFemale Spermatheca    18.3 Adult InseminatedFemale Spermatheca    16.1 Adult Ovary    5.5 Adult Testis    11.5 Adult Male Accessory Gland    16.2 Adult Carcass  (4318.8) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    9.7 Larval Midgut    24.7 Larval Hindgut no informative data Larval Malpighian Tubules    9.9 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.425 Larval Carcass no informative data Adult Head    217.8 Adult Eye no informative data Adult Brain    220.3 Adult Thoracic-Abdominal Ganglion    152.3 Adult Crop no informative data Adult Midgut    22.9 Adult Hindgut    22.1 Adult Malpighian Tubules no informative data Adult Fat Body    66.2 Adult Salivary Gland    21.1 Adult Heart    17.525 Adult VirginFemale Spermatheca    18.3 Adult InseminatedFemale Spermatheca    16.1 Adult Ovary    5.5 Adult Testis    11.5 Adult Male Accessory Gland    16.2 Adult Carcass    4318.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    217.8   NA  Eye    no informative data   NA  Brain    220.3   9.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    152.3   NA  Crop    no informative data   24.7  Midgut    22.9   no informative data  Hindgut    22.1   9.9  Malpighian Tubules    no informative data   no informative data  Fat Body    66.2   no informative data  Salivary Gland    21.1   NA  Heart    17.525   7.425  Trachea    NA   NA  VirginFemale Spermatheca    18.3   NA  InseminatedFemale Spermatheca    16.1   NA  Ovary    5.5   NA  Testis    11.5   NA  Male Accessory Gland    16.2   no informative data  Carcass    4318.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_00
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000045 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7478-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 Act79BGD1352 viable Act79Bf00364 Sterility Allele fertile Act79Bf00364 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Act79B Class Mutagen Stocks Known lesion Act79Bf00364 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Act79B Class Mutagen Stocks Known lesion Act79BR291H.Scer\UAS.P\T.T:Avic\GFP in vitro construct - site directed mutagenesis 2 Yes Act79BScer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes Act79BGD1352 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Act79BKK112081 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1352} NA P{KK112081} NA P{UASp-GFP.Act79B.R291H} NA P{UASp-GFP.Act79B} NA reporter construct P{Act79B-lacZ.CS} No P{Act79B-lacZ.K} No characterization construct P{Act79B::Act88FcFa} NA P{UASp-GFP.Act79B::Act88F.79B.C-T.88F.N-T} NA P{UASp-GFP.Act79B::Act88F.79B.N-T.88F.C-T} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Act79Bf00364 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR004001 (FlyBase Curators et al., 2004-) structural constituent of cytoskeleton inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000, FlyBase, 1992-)
Biological Process
CV term Evidence References
cytoskeleton organization inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
actin filament inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) non-traceable author statement (Swiss-Prot Project Members, 1986.7.21)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Act79B allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65684 DroID - A comprehensive database of gene and protein interactions. • FBgn0000045 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40444
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10940 Dere\GG16241 Dgri\GH14437 Dmoj\GI13569 Dpse\GA20380 Dsec\GM22426 Dvir\ActD1 Dwil\GK10683
Curated drosophilid orthologs	Dbuz\Act79B (Laayouni et al., 2000) Dpse\GA20380   Drep\Act79B   Dvir\ActD1
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15021 PB15019 NV18317 NV17514 NV16613 LH12777 LH23517 ISCW024111 FBgn0243304 FBgn0241435 FBgn0236777 FBgn0229916 FBgn0068537 FBgn0225298 FBgn0223736 FBgn0222121 FBgn0215949 FBgn0213473 FBgn0205554 FBgn0201951 FBgn0016404 FBgn0016403 FBgn0016401 FBgn0190420 FBgn0188352 FBgn0183289 FBgn0182114 FBgn0178973 FBgn0171407 FBgn0170702 FBgn0167384 JGI_V11_228751 JGI_V11_300012 JGI_V11_306442 JGI_V11_305550 JGI_V11_190689 FBgn0248103 FBgn0246293 FBgn0245743 FBgn0080375 FBgn0077895 FBgn0074904 FBgn0155390 FBgn0154665 FBgn0152492 FBgn0147062 FBgn0145949 FBgn0142448 FBgn0142332 FBgn0138061 FBgn0000047 FBgn0000046 FBgn0000044 FBgn0000042 FBgn0000043 FBgn0131828 FBgn0129468 FBgn0127871 FBgn0126544 FBgn0126512 FBgn0114243 FBgn0111890 FBgn0111005 FBgn0109157 FBgn0103145 FBgn0095318 FBgn0094620 FBgn0090854 FBgn0089247 FBgn0087980 CPIJ016462 CPIJ012573 CPIJ009808 CPIJ005785 BGIBMGA013945 ACYPI009912 ACYPI006035 ACYPI000064 GB18527 GB18365 GB17681 GB12614 AGAP011514 AGAP005095 ACT5C_ANOGA AAEL011197 AAEL005961 AAEL004631 AAEL001673 PB20873 PHUM268330 GLEAN_06296 GLEAN_03944 GLEAN_03326
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	9247 w*; P{UASp-GFP.Act79B}3-1 9248 w*; P{UASp-GFP.Act79B}2-2 9246 w*; P{UASp-GFP.Act79B.R291H}2-2 9245 P{UASp-GFP.Act79B.R291H}30-1, w* 18320 w1118; PBac{WH}Act79Bf00364
Harvard	- PBac{WH}Act79Bf00364
VDRC	v102588 P{KK112081}VIE-260B v9776 w1118; P{GD1352}v9776/TM3
Genomic Clones ( 1 )
	BACR17D14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT14584 GH04529 LD04994 LD18090 RE02927 RE12057 RE14441
Other clones	LD47405 RE74637 RH70883 yak-em_Act57B
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01402 GH20804 GH24728 HL01884 HL05811 HL08126 RH60940
Other clones	20877 31019 32170 36589 77469 102460 104516 108500 192186 193449 211134 CK01.54A.C7 CK01.130A.E2 Dmel_neb_016025_0669_3378 Dmel_neb_016577_0898_0794 EK100349 EK142440 EK173209 EK291450 EK294539 EP15108 Nfly-026
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000045 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40444
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The Act42A gene may be derived from the Act79B gene by retroposition. (Betran et al., 2002)
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Age related changes in Act79B expression have been studied by Northern analysis. (Labuhn and Brack, 1997) There are differences in the level of Act79B gene expression among the various abdominal muscles of both sexes, abdominal expression is not limited primarily to male sex structures. (Ohshima et al., 1997) Sequence analysis demonstrates insect muscle actins form a distinct family of closely related proteins significantly diverged from cytoplasmic actins. (Mounier et al., 1992) Translation of actin RNA in early embryos injected with initiation factors has been studied. (Hongo and Jacobs-Lorena, 1991) Encodes a tubular muscle actin expressed in adult legs and tubular muscles of thorax, including direct flight muscles, pleurosternal muscles and muscles of various leg segments (FBrf0038990). In addition, Act79B is expressed in muscles that support the head and abdomen, in the scutellar pulsatile organ and in two pairs of abdominal muscles that are present only in male flies (FBrf0049489). One of three actin genes expressed in wing development each with its characteristic developmental profile; peak activity at 80h of pupal age (FBrf0042391).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079486 RefSeq (Proteins) • NP_524210 DDBJ / EMBL / GenBank • AAA28317 AAA28318 AAF51800 AAM50595 AI064220 AY118735 M18827 M18828 M18829 Entrez Gene - A searchable database of RefSeq genes. • 40444 UniProtKB/Swiss-Prot • P02574
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin/actin-like conserved site (IPR020902) Actin-like (IPR004000) Actin, conserved site (IPR004001)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65684 DroID - A comprehensive database of gene and protein interactions. • FBgn0000045 DRSC - Results from RNAi screens. • FBgn0000045 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000045 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7478-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000045 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40444 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40444 modMine - Data generated by the modENCODE project. • FBgn0000045 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15021 PB15019 NV18317 NV17514 NV16613 LH12777 LH23517 ISCW024111 FBgn0243304 FBgn0241435 FBgn0236777 FBgn0229916 FBgn0068537 FBgn0225298 FBgn0223736 FBgn0222121 FBgn0215949 FBgn0213473 FBgn0205554 FBgn0201951 FBgn0016404 FBgn0016403 FBgn0016401 FBgn0190420 FBgn0188352 FBgn0183289 FBgn0182114 FBgn0178973 FBgn0171407 FBgn0170702 FBgn0167384 JGI_V11_228751 JGI_V11_300012 JGI_V11_306442 JGI_V11_305550 JGI_V11_190689 FBgn0248103 FBgn0246293 FBgn0245743 FBgn0080375 FBgn0077895 FBgn0074904 FBgn0155390 FBgn0154665 FBgn0152492 FBgn0147062 FBgn0145949 FBgn0142448 FBgn0142332 FBgn0138061 FBgn0000047 FBgn0000046 FBgn0000044 FBgn0000042 FBgn0000043 FBgn0131828 FBgn0129468 FBgn0127871 FBgn0126544 FBgn0126512 FBgn0114243 FBgn0111890 FBgn0111005 FBgn0109157 FBgn0103145 FBgn0095318 FBgn0094620 FBgn0090854 FBgn0089247 FBgn0087980 CPIJ016462 CPIJ012573 CPIJ009808 CPIJ005785 BGIBMGA013945 ACYPI009912 ACYPI006035 ACYPI000064 GB18527 GB18365 GB17681 GB12614 AGAP011514 AGAP005095 ACT5C_ANOGA AAEL011197 AAEL005961 AAEL004631 AAEL001673 PB20873 PHUM268330 GLEAN_06296 GLEAN_03944 GLEAN_03326
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	143060_f_at (Kristensen et al., 2005) act 79B (Labuhn and Brack, 1997) act79B (He and Haymer, 1995, Bossuyt et al., 2009, Sharma et al., 2011) Act79B (Stuart et al., 2007, Montana and Littleton, 2006, Blanco et al., 2010, Dorus et al., 2006, Bai et al., 2008, Cherbas et al., 2011) Actin (Balasubramanian et al., 2004, Eberharter and Becker, 2004, Jones, 1999, Hongo and Jacobs-Lorena, 1991) actin (Xia and Karin, 2004, Kwon and Scholey, 2004, Strickland and Burgess, 2004, Delmas et al., 2004, Miller, 2003, Muller and Littlewood-Evans, 2001, Adams et al., 2000, Jacinto and Baum, 2003, Baum, 2002, Biggin, 2001, Noselli and Agnes, 1999, OOta and Saitou, 1999, Brault et al., 1999, Bearer, 1991, Padash Barmchi et al., 2005) CG7478 (Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Cammarato et al., 2011) D (Bondinas et al., 2002, Bondinas et al., 2001) mus79B (White and Crother, 1999)
Name Synonym	79B Actin (Roy and VijayRaghavan, 1999) actin (Bosch et al., 2005, Costantino et al., 2007, Lo, 2006, Harris and Peifer, 2004, Zeitler et al., 2004, Sordella and Van, 2006, Baehrecke, 2003, Bai et al., 2007) Actin (Mulinari et al., 2007, Griemert et al., 2007, Jaiswal et al., 2006) Actin 79B (D'Avino et al., 2008, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 105 )
Generate a list of	All references relating to this gene ( 105 )
List References by type	Research paper  ( 55 ) Supplementary material  ( 6 ) Review  ( 25 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 7 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 3 )
	Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Sharma et al., 2011, Chemosphere 82(3): 370--376 Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. [FBrf0212610] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...